Liraglutide is given once a day as an injection just under the surface of the skin.
Store unopened packs of liraglutide in a fridge. Once in use, you can keep the pre-filled pen for up to 30 days at room temperature.
The most common side-effects are nausea and diarrhoea - these usually reduce over time. If at any time you develop severe stomach pain with sickness, speak with a doctor as soon as possible.
|Type of medicine||An antidiabetic injection|
|Used for||Type 2 diabetes mellitus|
Xultophy® (combination brand of liraglutide with insulin degludec)
|Available as||Subcutaneous injection in the form of a pre-filled pen|
Insulin is a hormone which is made naturally in your body, in the pancreas. It helps to control the levels of sugar (glucose) in your blood. If your body does not make enough insulin, or if it does not use the insulin it makes effectively, this results in the condition called diabetes (diabetes mellitus).
People with diabetes need treatment to control the amount of sugar in their blood. This is because good control of blood sugar levels reduces the risk of complications later on. Some people can control the sugar in their blood by making changes to the food they eat but, for other people, medicines are given alongside the changes in diet. Liraglutide is one of the medicines that are prescribed for people with type 2 diabetes.
Liraglutide works in three ways. It increases the amount of insulin produced by your body which then reduces the level of sugar in your blood. It also reduces the amount of a substance called glucagon being produced by your pancreas. Glucagon causes your liver to produce more sugar, so by reducing the amount of glucagon in your body, this also helps to reduce the levels of sugar in your blood. Liraglutide also works on your stomach so that food passes more slowly through it. This means that the sugar from your meals takes longer to get into your blood.
Liraglutide is given as an injection just under the surface of the skin. It is administered using an injection device called a pre-filled pen. It is used in addition to other antidiabetic medicines.
Liraglutide, in the brand Saxenda®, can also be used to manage obesity and weight loss together with a reduced-calorie diet and increased physical exercise. This leaflet is written for people using liraglutide for diabetes. If you have been prescribed Saxenda® for weight loss please also refer to the manufacturer's patient information leaflet.
Before using liraglutide
Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start using liraglutide it is important that your doctor knows:
- If you are pregnant, trying for a baby or breastfeeding.
- If you have a problem with your stomach or digestive system.
- If you have any problems with the way your liver works, or with the way your kidneys work.
- If you have an overactive thyroid gland (hyperthyroidism).
- If you are taking any other medicines. This includes any medicines you are taking which are available to buy without a prescription, as well as herbal and complementary medicines.
- If you have ever had an allergic reaction to a medicine.
How to use liraglutide
- Before you start the treatment, read the manufacturer's printed information leaflet from inside the pack as well as any information you are given by your doctor or diabetes clinic. The manufacturer's leaflet will provide you with a full list of the side-effects which you may experience.
- Use liraglutide exactly as your doctor tells you to. Your doctor or diabetes nurse will show you how to inject yourself. Liraglutide should be injected into the skin on your upper arms, thigh, or tummy (abdomen). Try to choose a different injection site for each of your injections.This will help to prevent skin problems and difficulties in injecting.
- Liraglutide is injected once a day. Your doctor will tell you what dose to use. It can be given at any time of day either before or after meals, but it is best if you use it at the same time each day.
- If you forget a dose, use the injection as soon as you remember. If you do not remember until more than 12 hours after your dose was due, then skip the missed dose and have your next injection as usual on the following day. Do not take an extra dose or increase your dose to make up for the missed one.
Getting the most from your treatment
- It is important that you keep your regular doctor's and clinic appointments. This is so that your progress can be monitored. You will need regular check-ups with an eye clinic and a foot clinic as well as with your doctor and diabetes clinic.
- Your doctor may recommend that you test for sugar (glucose) in your blood or urine regularly to check that your diabetes is being controlled. Your doctor or diabetes nurse will show you how to do this.
- If you have been given advice by your doctor about changes to your diet, stopping smoking or taking regular exercise, it is important for you to follow the advice you have been given.
- Make sure you know what it feels like if your blood sugar is low. This is known as hypoglycaemia, or a 'hypo'. Although liraglutide is unlikely to cause low blood sugar, other medicines that you are taking for diabetes alongside it may. The first signs of hypoglycaemia are feeling shaky or anxious, sweating, looking pale, feeling hungry, having a feeling that your heart is pounding (palpitations), and feeling dizzy. If this happens, eat something containing sugar, such as dextrose tablets, jelly babies or a sugary drink (non-diet), and then follow this up with a snack such as a sandwich or a banana.
- If you are a driver you should take special care, as your ability to concentrate may be affected if your diabetes is not well controlled. You may be advised to check your blood sugar levels before you travel and to have a snack with you on long journeys.
- Do not drink alcohol, as it can affect the control of your blood sugar. Ask your doctor if you need further advice about this.
- If you get unusually thirsty, pass urine more frequently than normal, or feel very tired, you should let your doctor know. These are signs that there is too much sugar in your blood and your treatment may need adjusting.
- Check with your doctor before taking up any new physical exercise, as this will have an effect on your blood sugar levels and you may need to check your blood or urine levels more regularly.
- If you are due to have an operation or dental treatment, you should tell the person carrying out the treatment that you have diabetes and give them a list of the medicines you are taking.
- If you buy any medicines, always check with a pharmacist that they are suitable for you to take.
- Treatment for diabetes is usually lifelong. Continue with liraglutide unless you are told otherwise by your doctor
Can liraglutide cause problems?
Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with liraglutide. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.
|Very common liraglutide side-effects (these affect more than 1 in 10 people)||What can I do if I experience this?|
|Feeling sick (nausea)||Stick to simple foods - avoid rich or spicy meals|
|Diarrhoea||Drink plenty of water to replace lost fluids|
|Common liraglutide side-effects (these affect fewer than 1 in 10 people)||What can I do if I experience this?|
|Stomach upset, indigestion||Stick to simple foods|
|Feeling dizzy or tired||Do not drive and do not use tools or machines until you feel better|
|Headache||Drink plenty of water and ask your pharmacist to recommend a suitable painkiller. If the headaches continue, let your doctor know|
|Lack of appetite, loss of weight, increased heart rate, constipation, rash, toothache, injection site problems, nose and throat infections||Let your doctor or diabetes clinic know if any of these become troublesome|
Important: medicines like liraglutide can cause persistent and severe tummy (abdominal) pain with sickness in a few people. If this happens to you, you should speak with your doctor as soon as possible as these can be symptoms of an inflamed pancreas (pancreatitis).
If you experience any other symptoms which you think may be due to the injections, speak with your doctor or pharmacist for further advice.
How to store liraglutide
- Keep all medicines out of the reach and sight of children.
- Liraglutide can be kept for four weeks at room temperature, as long as this is below 30°C and it is kept away from direct heat and sunlight. It is, however, best to store your unopened packs in a refrigerator. Do not freeze liraglutide.
- Pre-filled pens must be discarded one month after being first used.
Important information about all medicines
Never take more than the prescribed dose. If you suspect that you or someone else might have taken an overdose of this medicine, go to the accident and emergency department of your local hospital. Take the container with you, even if it is empty.
This medicine is for you. Never give it to other people even if their condition appears to be the same as yours.
Do not keep out-of-date or unwanted medicines. Take them to your local pharmacy which will dispose of them for you.
If you have any questions about this medicine ask your pharmacist.
Further reading and references
Manufacturer's PIL, Victoza® 6 mg/ml solution for injection in pre-filled pen; Novo Nordisk Limited, The electronic Medicines Compendium. Dated October 2019.
British National Formulary, 80th Edition (Sep 2020); British Medical Association and Royal Pharmaceutical Society of Great Britain, London.