Epididymo-orchitis Causes, Symptoms and Treatment

Authored by , Reviewed by Dr Colin Tidy | Last edited | Meets Patient’s editorial guidelines

Epididymo-orchitis is an inflammation of the epididymis and/or testicle (testis). In adults, epididymo-orchitis is usually due to infection, most commonly from a urine infection or a sexually transmitted infection. A course of antibiotic medicine will usually clear the infection. Full recovery is usual. Epididymo-orchitis complications are uncommon.

  • Epididymitis means inflammation of the epididymis (the structure next to the testicle (testis) that is involved in making sperm).
  • Orchitis means inflammation of a testicle.

As the epididymis and testis lie next to each other, it is often difficult to tell if the epididymis, the testis, or both are inflamed. Therefore, the term epididymo-orchitis is often used.

Testis - epididymitis and orchitis

Testis with explanation of epididymitis and orchitis

In boys who have not reached puberty, symptoms are often not due to an infection. The most common cause at this age is thought to be urine refluxing into the duct that sperm pass down (the ejaculatory duct, or vas deferens). It can also be due to urine infection.

Rarely, epididymo-orchitis in children can be a complication of Henoch-Schönlein purpura, a condition caused by inflammation of the blood vessels.

In over-14s, most cases of epididymo-orchitis are due to an infection. Causes of infection include the following:

A complication from a urine infection

Germs (bacteria) such as E. coli that cause urine infections can sometimes track down the vas deferens to cause an epididymo-orchitis. This can happen at any age and is the most common cause of epididymo-orchitis in men aged over 35 years. This is because partial blockage of urine flow becomes more common with increasing age, due to an enlarged prostate gland or narrowing of the urethra (urethral stricture). The urethra is the tube that urine flows out of from the bladder. Partial blockage of urine makes you more prone to develop urine infections.

Sexually transmitted infection

A sexually transmitted infection is the most common cause of epididymo-orchitis in young men (but can occur in any sexually active man). It most commonly occurs with chlamydial and gonorrhoeal infections. In men, these infections typically infect the urethra to cause a urethritis. However, sometimes the infection can track down the vas deferens to the epididymis and testicle (testis).

The mumps virus

The mumps virus used to be a common cause. Most people with mumps develop swelling of the parotid salivary glands. However, mumps in boys also causes epididymo-orchitis in about 1 in 5 cases. The virus gets to the testicles via the bloodstream. This cause is now uncommon since the measles, mumps and rubella (MMR) immunisation is now routinely given to children.

An operation to the prostate gland or urethra

This may allow germs (bacteria) into the urethra which may track down to the testicles. Epididymo-orchitis used to be a common complication after removal of the prostate gland (prostatectomy). This is now rare due to better surgical techniques.


Epididymo-orchitis can occasionally be a side-effect of a medicine called amiodarone. It normally occurs at doses above 200 mg, especially when the dosage range reaches 400-800 mg.

Uncommon causes of epididymo-orchitis

Other viral infections are uncommon causes of epididymo-orchitis. Infection from other parts of the body can, rarely, travel in the blood to the testicles, such as tuberculosis (TB) and brucellosis. When this happens it is usually in people who have a problem with their immune system (for example, people with AIDS). Schistosomiasis is a tropical infectious disease that can cause epididymo-orchitis. Men with Behçet's disease may develop inflamed testicles to cause a non-infective epididymo-orchitis. Injury to the scrotum can cause inflammation of the epididymis and testicle.

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Epididymo-orchitis occurs in about 1 in 1,000 males. It is common in men aged 15-30 years and in men aged over 60 years. It does not occur very often before puberty. About 3 in 10 boys who have mumps after puberty develop orchitis. Your risk of getting epididymo-orchitis is increased if you have a catheter or other instruments inserted into the urethra.

Symptoms usually develop quickly - over a day or so. The affected epididymis and testicle swell rapidly and the scrotum becomes enlarged, tender and red. It can be very painful.

There may be other symptoms if the epididymo-orchitis is a complication from another infection. For example: pain on passing urine if you have a urine infection; a discharge from the penis if you have a urethral infection; etc. As with any infection, you may have a high temperature (fever) and feel generally unwell.

Tests to look for infecting germs (bacteria)

A urine test will usually be done if a urine infection appears to be the root cause. A sample (swab) from the urethra or other tests may be done if a sexually transmitted infection is thought to be the root cause. Sexual partners of people with epididymo-orchitis caused by a sexually transmitted infection will also need testing.

Ideally, you should be referred to a sexual health specialist within one day to have an assessment unless your doctor thinks mumps orchitis is the cause of your symptoms.

See the separate leaflets called Genital Chlamydia, Urethritis and Urethral Discharge in Men and Gonorrhoea for more details.

Blood tests

You may need blood tests including a full blood count, CRP and ESR to look for evidence of infection and inflammation.

Tests of the urinary tract

Tests to look into the urethra and bladder may be needed if a urine infection is the cause and this is thought to be due to partial blockage of urine flow or other urinary tract abnormalities. If the germ causing your symptoms is thought to have come from a urine infection, you will need referral for further tests of your urinary tract.

See the separate leaflets called Urine Infection in Men and Urine Infection in Children for more details. 

A course of antibiotic medicines is usually advised as soon as epididymo-orchitis is diagnosed. These normally work well. Pain usually eases within a few days but swelling may take a week or so to go down, sometimes longer. The choice of the antibiotic depends on the underlying cause of the infection.

If your symptoms have not improved within three days, you should recontact your doctor. You should also be reviewed after two weeks, even if your symptoms have gone.

If a sexually transmitted infection is the cause then you should not have sex until treatment and follow-up have been completed. Sexual partners of men with epididymo-orchitis caused by a sexually transmitted infection may also need antibiotic treatment.

Antibiotics do not kill viruses and they are not needed if a viral infection is the cause - for example, mumps.

You may find that supporting underwear helps to ease the pain. Painkillers and ice packs (never apply ice directly to your skin) will also ease the pain.

Most people recover fully from epididymo-orchitis and complications are uncommon. Possible complications include:

  • Ongoing pain or swelling in the testicle - this settles within three months in more than four in five men with epididymo-orchitis.
  • A collection of pus due to infection (an abscess) occasionally develops in the scrotum. This may need a small operation to drain the pus.
  • Reduced fertility in the affected testicle (testis), especially in cases caused by the mumps virus.
  • An ongoing (chronic) inflammation occasionally develops.
  • Rarely, serious damage to the testicle may occur and result in dead tissue (gangrene) in the testicle that needs to be surgically removed.

Torsion of the Testis

Epididymal Cyst

Further reading and references