Latest studies
- Recruiting
How treatments affect people recently diagnosed with follicular lymphoma. A study over time
This study looks at how treatments affect people newly diagnosed with follicular lymphoma. It will collect information during your usual hospital visits, helping us understand the illness better and hopefully improve future care for patients in the UK and worldwide. You won't have extra tests or treatments.
Malignant neoplasms, stated or presumed to be primary, of lymphoid, haematopoietic and related tissueNorthern Ireland - Recruiting
Supermarket voluntary price promotion ban: a public health study
This study looks at what happens when two UK supermarkets stop using special offers on unhealthy foods. Researchers want to see how this affects what people buy, their health, and the businesses involved. It aims to understand if stopping these deals helps people eat better.
The main focus of this work is the prevention of obesity and risk of chronic non-communicable diseases through reduction of consumption of high fat salt sugar foods.Northern Ireland - Completed
A study to assess nicotine uptake to the bloodstream after use of six different oral nicotine products in adult smokers
This study looks at how much nicotine gets into the blood when adult smokers use different nicotine products. It also checks how people feel about these products, their flavour, and how they affect the urge to smoke and mood. Participants will stay at a research site for 8 days.
Nicotine uptakeNorthern Ireland - Completed
Understanding corridor care in UK emergency departments
This study looks at how many patients are cared for in places like hospital corridors when emergency departments are busy. It wants to understand who these patients are and why they're there, to help improve emergency care across the UK.
UK Emergency Department use of escalation areasNorthern Ireland - RecruitingPhase III
IIH-Advance: A randomised clinical trial to determine the effects of weight loss, induced by a weight loss drug (Tirzepatide), in adults with active idiopathic intracranial hypertension
This study looks at whether a weight loss drug, Tirzepatide, can help adults with a condition called Idiopathic Intracranial Hypertension (IIH). IIH causes high pressure in the head, leading to headaches and eye problems. We want to see if losing weight with this drug can improve these symptoms.
Idiopathic intracranial hypertensionNorthern Ireland - RecruitingPhase III
Investigating whether prolonged antibiotics can prevent permanent Pseudomonas infection in bronchiectasis
This study looks at whether early, strong antibiotic treatment can stop a lung infection called Pseudomonas from becoming permanent in people with bronchiectasis. We hope to reduce flare-ups and improve health.
BronchiectasisNorthern Ireland - CompletedPhase I
A Phase I trial of LY3143921 hydrate in solid tumours
This study looks at a new drug, LY3143921 hydrate, for advanced solid cancers. It aims to find a safe dose and understand its effects, especially in cancers where usual treatments haven't worked or aren't suitable. This is the first time it’s being tested in people.
Colorectal Cancer (CRC), High Grade Serous Ovarian Cancer (HGSOC), Non-Small Cell Lung Cancer (NSCLC; Squamous Cell Variant), Squamous Carcinoma of the Oesophagus, Squamous Carcinoma of the Head and Neck (Human Papillomavirus Negative), Urothelial Cancer, Breast Cancer (Triple Negative Type), Pancreatic CancerNorthern Ireland - RecruitingPhase I/II
A two-part study to investigate the effects in adults of two doses of golexanolone in patients with primary biliary cholangitis with fatigue and cognitive dysfunction
This study looks at a new drug, golexanolone, for people with a liver condition called Primary Biliary Cholangitis (PBC) who also feel very tired and have trouble thinking clearly. Researchers want to see if it's safe, how it works in the body, and if it helps these symptoms.
Patients with primary biliary cholangitis with fatigue and cognitive dysfunctionNorthern Ireland - Recruiting
A study to find out if a new blood test (microRNA) can be used to monitor people after surgery for seminoma or dysgerminoma cancer
This study looks at a new blood test to see if cancer has come back in people treated for specific early-stage cancers like seminoma or dysgerminoma. It aims to reduce the need for scans by seeing if a simple blood test can do the job and help find cancer recurrence earlier.
Seminoma and dysgerminomaNorthern Ireland - Recruiting
Comparing large chest drains with small chest drains to explore the best treatments for chest injury
This study compares two types of tubes, small and large, used to drain air or blood from the chest after an injury. It aims to find out which one works best and is safer for patients, and if it could save the NHS money.
Specialty: Trauma and Emergency Care, Primary sub-specialty: Emergency Medicine; Health Category: Injuries and accidents, Respiratory; Disease/Condition: Injuries to the thoraxNorthern Ireland - Recruiting
Pharmacogenetics to avoid loss of hearing UK
This study uses a quick genetic test to protect newborn babies from hearing loss. Some babies given a common antibiotic, gentamicin, can become deaf if they have a certain gene. This test identifies those babies quickly so they can receive a safer treatment. It's being tested across the UK.
Use of a genetic test to detect the m.1555A>G variant associated with aminoglycoside-induced hearing loss in neonatal care unitsNorthern Ireland - RecruitingNot Specified
Study of whether radiotherapy after surgery to treat a weakened or broken bone caused by cancer helps to reduce pain and improve quality of life
This study looks at whether radiation treatment after surgery for cancer-related broken bones helps with pain and quality of life. Some people will get radiation, others won't immediately, to see if it makes a difference and if it's truly needed after surgery.
Bone metastasesNorthern Ireland - Completed
Testing how well a new online platform can support people living with overweight or obesity to lose weight
This study tested a new online tool called the STOP portal to help adults who are overweight or obese manage their weight. Participants used the portal to track their food, activity, and weight for three months, to see if it helped with weight loss.
Individuals living with overweight or obesityNorthern Ireland - Completed
Performance evaluation of type 1 diabetes genetic risk test
This study looks at a new genetic test for Type 1 Diabetes. It aims to help doctors tell the difference between Type 1 and other types of diabetes more easily. This is important for ensuring people get the right treatment early.
Discrimination of Type 1 Diabetes from other non-autoimmune diabetes such as type 2 diabetes, monogenic diabetes or secondary diabetes.Northern Ireland - Recruiting
A study evaluating whether immobilisation or no immobilisation affects pain scores in toddlers fractures
This study looks at how best to treat toddlers' shin bone breaks. It compares using a cast or boot with no cast, to see which helps children with pain, convenience, and recovery. It aims to find the safest and most practical approach for families and the NHS.
Toddler's fractures - non-displaced spiral fractures of the tibiaNorthern Ireland - Recruiting
In-Touch: person-centered palliative care to improve comfort and connection in advanced dementia
This study aims to make life better for people with advanced dementia in nursing homes. It tests new ways to keep residents comfortable and connected, and helps their families plan future care. It also supports staff caring for them.
DementiaNorthern Ireland - RecruitingPhase IV
A platform trial to identify the best treatments for critically ill children admitted to paediatric intensive care
This study is looking for better ways to care for very sick children in intensive care. We are testing common treatments to see which ones work best and are safest, hoping to improve their recovery and future well-being.
Critical illnessNorthern Ireland - Recruiting
Clinical performance evaluation of a Randox Respiratory-fleX device for respiratory infections
This study aims to check how well a new medical device, the Randox Respiratory-fleX, can find common bugs that cause chest infections. It compares the new device with one already in use to make sure it's accurate and quick. If you’re aged 18 or over and having a respiratory test, you might be able to help.
Detection and discrimination of causative pathogens of respiratory infections.Northern Ireland - Recruiting
Effect of fish and omega 3 supplements on the heart health of young adults
This study looks at how fish or omega-3 supplements affect heart health in young adults. It wants to see if eating more fish or taking supplements can improve body levels of omega-3, which is linked to a lower risk of heart disease.
Cardiovascular disease preventionNorthern Ireland - Recruiting
A population-based digital study offering people testing for cancer genes, to identify people at increased risk of cancer so they can take steps to prevent it or detect it early
This study offers a genetic test for cancer risk to people in the UK. It uses a saliva sample to check for genes linked to breast, ovarian, bowel, and womb cancers. The aim is to find people at higher risk so they can take steps to prevent cancer or detect it early.
CancerNorthern Ireland - Recruiting
A UK study of minimally invasive emergency treatment of sudden bleeding from the lower bowel
This study looks back at records of patients in the UK and other countries who had a special X-ray guided procedure called embolisation to stop sudden bleeding from their bowel. It aims to understand how well this treatment works and to improve care for similar cases in the future.
Patients who have undergone angiography +/- embolisation for acute non-variceal lower GI haemorrhage.Northern Ireland - Completed
The impact of trainer behaviour on trainee cognitive load and performance during vascular surgery simulation
This study looks at how a trainer's behaviour affects surgical trainees learning. It compares supportive trainers to rude ones in a simulated operating room. The goal is to improve training and patient safety by understanding this impact.
Surgical trainee intraoperative cognitive load, technical skills and non-technical skillsNorthern Ireland - Recruiting
Impact of having a long lie after a fall
This study looks into what happens when someone falls and can't get up for a long time. It aims to improve how we help people waiting for assistance, making things better for patients, ambulance services, and care homes.
Specialty: Trauma and Emergency Care, Primary sub-specialty: Pre-hospital; Health Category: Disputed Aetiology and OtherNorthern Ireland - Recruiting
Can we safely reduce the number of days of radiotherapy needed to treat people with breast cancer who need boost treatment?
This study looks at whether we can safely give breast cancer patients who need an extra 'boost' of radiotherapy a shorter 5-day treatment instead of the usual 15 days. It compares two different 5-day boost doses with the standard 15-day boost.
Breast cancerNorthern Ireland - Recruiting
FORENSIC-UK: Fusion versus Best Conservative Care
This study looks at whether an operation called spinal fusion helps people with ongoing severe lower back pain better than other non-surgical treatments. It also checks if the operation is good value for the NHS.
Low back painNorthern Ireland - Completed
A study exploring healthcare professionals' experiences using a ready-to-use botulinum toxin for cosmetic treatments in UK aesthetic clinics
This study looks at how UK skincare doctors and nurses use a new, ready-to-use treatment for facial lines like frown lines and crow's feet. It aims to see if this new product is easy to use and helps clinics run smoothly.
Facial lines, specifically glabellar (frown) lines and lateral canthal (crow’s feet) linesNorthern Ireland - Recruiting
Introducing diabetes checks in dental settings: a study to explore whether dental settings can be used to identify new cases of prediabetes and diabetes
This study looks at whether dentists can help spot early signs of diabetes in their patients. Dentists are often seen regularly, which might make them a good place to check for diabetes early. It involves a simple questionnaire and a finger-prick test.
DiabetesNorthern Ireland - RecruitingPhase III
Implementation of Metformin theraPy to Ease DEcline of kidney function in Polycystic Kidney Disease (IMPEDE-PKD): randomised placebo-controlled trial
This study looks at metformin, a common diabetes drug, to see if it can slow kidney disease in people with ADPKD. It's for adults aged 18-70 and involves taking tablets daily for two years to understand if it helps protect kidneys.
Autosomal dominant polycystic kidney disease (ADPKD)Northern Ireland - Recruiting
A trial examining if less fluid administration is better than standard fluid administration in children undergoing kidney transplant
This study looks at how much fluid children should get during and after a kidney transplant. We want to find out if giving a bit less fluid, based on body size, is better than the usual amount for helping children recover faster and spend less time in hospital.
Fluid management in paediatric kidney transplantationNorthern Ireland - RecruitingPhase IV
Examining antibiotics for ulcerated skin cancer surgical excision
This study looks at whether antibiotics can prevent infections after surgery for ulcerated skin cancer. People will either get an antibiotic or a dummy pill to see if it reduces wound infections, helping doctors decide if antibiotics are needed for this surgery.
Antibiotic treatment for the prevention of surgical site infection in participants receiving ulcerated skin cancer excisionNorthern Ireland - Recruiting
Holistic approach for improving the care of people with multiple conditions after critical illness
This study looks at a new support program for people with multiple health issues after a stay in intensive care. It aims to help them as they return home and improve their recovery and wellbeing.
Sequalae of critical illnessNorthern Ireland - Completed
The effect of 8 weeks probiotic supplementation on sleep quality in adults aged 18 years and over
This study looks into whether taking a probiotic supplement for eight weeks can improve sleep for adults who aren't happy with their sleep. Researchers will compare those taking the probiotic to those taking a dummy pill.
Healthy adults with dissatisfaction with their current sleepNorthern Ireland - Recruiting
A UK-wide study to find out which routine top-up feeds for extremely preterm babies when there is insufficient own mother’s milk, reduce the likelihood of necrotising enterocolitis and improve survival and brain development
This study looks at the best way to feed very early babies, specifically those born before 29 weeks. It compares donor breast milk to special formula and different ways of fortifying milk to see which helps babies survive, grow, and avoid serious gut and brain problems.
Necrotising enterocolitis, mortality, and cognitive impairment in preterm babies born below 29 weeks gestationNorthern Ireland - Not yet recruitingPhase II
A trial to evaluate the safety and efficacy of treatment with azacitidine in patients with symptomatic non-obstructive hypertrophic cardiomyopathy
This study looks at a new drug, azacitidine, for non-obstructive hypertrophic cardiomyopathy (nHCM), a common heart condition. It aims to see if azacitidine is safe and effective in treating nHCM, which currently has limited direct treatments.
Symptomatic non-obstructive hypertrophic cardiomyopathy (nHCM)Northern Ireland - RecruitingPhase III
Phase III study of revumenib in combination with intensive chemotherapy in newly diagnosed NPM1-mutated AML
This study looks at adding a new drug, revumenib, to standard chemotherapy for a type of blood cancer called AML when it has a specific gene change (NPM1 mutation). It aims to see if this new combination works better to treat the cancer.
Newly diagnosed acute myeloid leukemia (AML) with an NPM1 mutationNorthern Ireland - Not yet recruiting
The National Unified Renal Translational Research Enterprise for biosampling patients with rare kidney disease
This study collects samples and health details from children aged 0-16 with rare kidney diseases like glomerulonephritis, and healthy children. Researchers hope to better understand these conditions, find early signs of problems, and develop improved, personalised treatments by studying blood, urine, and medical records.
Children and young people with rare kidney diseases. Glomerulonephritis (GN): Including subtypes such as IgA Vasculitis Nephritis (IgAVN), IgA Nephropathy (IgAN), Idiopathic Nephrotic Syndrome (iNS), C3 Glomerulopathy/Membranoproliferative GN (MPGN), Post-infectious Glomerulonephritis (PIGN), Lupus Nephritis (LN), ANCA-associated vasculitis (AAV), and Membranous Nephropathy (MN)Northern Ireland - Completed
Erythropoietic protoporphyria life impact and genetic health trajectory (EPP LIGHT): a survey of adults and adolescents in Europe living with EPP
This study is gathering information through an online survey about how living with Erythropoietic Protoporphyria (EPP) or X-linked Protoporphyria (XLP) affects people in Europe. It looks at daily life, symptoms, and healthcare, helping us understand the condition better for future improvements.
Erythropoietic protoporphyria and X-linked protoporphyria (collectively referred to as EPP)Northern Ireland - Completed
Does adding a return date to bowel screening letters increase test completion among people who have never taken part before in deprived areas?
This study looks at whether adding a suggested return date to bowel screening letters helps more people, especially those who haven't done it before and live in certain areas of Northern Ireland, to complete the test for bowel cancer.
Bowel cancer screeningNorthern Ireland - RecruitingPhase II
Determining the role of synthetic cannabinoids in eye pressure and tolerability measurements
This study is testing a new drug (ART27.13) for glaucoma. Glaucoma can damage eyesight by increasing pressure inside the eye. We want to see if ART27.13 can safely lower this eye pressure without the side effects of other similar drugs.
Ocular hypertension or early primary open angle glaucomaNorthern Ireland - Completed
Clinical performance evaluation of a quantitative Randox STI-fleX qPCR device for sexually transmitted infections
This study is testing a new device called STI-fleX qPCR to detect common sexually transmitted infections (STIs). Researchers are using existing, anonymous samples to see how well this new test works compared to current methods. The goal is to improve STI testing.
Detection of sexually transmitted infectionsNorthern Ireland - RecruitingPhase II
Research study for people who have cerebral small vessel disease (cSVD, damaged small blood vessels in the brain) and a stroke, which may lead to impaired memory and thinking and then dementia
This study looks for new ways to treat people who've had a stroke and also have damaged tiny blood vessels in their brain. We're testing two existing drugs, cilostazol and isosorbide mononitrate, to see if they can help prevent memory and thinking problems that can sometimes lead to dementia after a stroke.
Clinical syndrome of cortical or large subcortical stroke or TIA (TACS, PACS or cerebellar POCS)Northern Ireland - Recruiting
Safety and autonomy for everyone at Home. Understanding safety, risks and harm-benefit balances arising from home-based care.
This study wants to make care at home safer for older people. Researchers will review existing information and talk to care workers and people receiving care to understand how to improve home care and find out what works best. It aims to help make home care better for everyone.
Care received at home, focusing on older adults (>60 years old).Northern Ireland - RecruitingPhase III
Evaluation of intravenous therapy (i.e. injection into the vein) in asthma
This study looks at which injection works best for children and young people with severe asthma attacks. Doctors want to find out if aminophylline, magnesium sulphate, or salbutamol is the most effective and acceptable treatment to help them breathe better.
Severe acute asthmaNorthern Ireland - Recruiting
PCN-CRP: a programme for improving the prediction and prevention of preterm birth and women’s experience of care
This study aims to understand and prevent premature births. It's collecting health information from pregnant women at risk, combining it with other studies to find better ways to predict, stop, and improve care around early births for families in the future.
Prediction and prevention of preterm birthNorthern Ireland - Recruiting
Preventing miscarriage through platform testing of multiple novel interventions
This study looks at whether taking omega-3 (DHA) supplements can help prevent miscarriage in women who have had two or more miscarriages. Researchers want to see if different doses of DHA can increase the chance of a baby being born healthy and later in pregnancy.
Medical condition: Miscarriage Medical condition in lay language: Miscarriage Therapeutic areas: Diseases [C] - Female diseases of the urinary and reproductive systems and pregancy complications [C13]Northern Ireland - RecruitingPhase III
A study of photodynamic therapy for long-lasting central serous chorioretinopathy
This study looks into a laser treatment called photodynamic therapy (PDT) for a long-lasting eye condition called central serous chorioretinopathy (CSCR). It compares PDT to a dummy treatment to see if it helps improve vision and reduce fluid in the eye.
Central Serous Chorioretinopathy (CSCR)Northern Ireland - Recruiting
Care of people at the end of their lives in the rural and coastal communities of the South West Peninsula of England
This study aims to improve end-of-life care in rural and coastal areas of Devon, Cornwall, and Somerset. It involves talking to patients, families, and professionals to understand current care and find ways to make it better for everyone involved.
People at the end of life, family members and professionalsNorthern Ireland - Completed
How common is intraoperative pain occur during caesarean delivery surgery when the patient is awake and what is the impact on mothers?
This study looks at how often pain happens during C-sections when mums are awake, and how this pain affects them. It aims to improve care for future C-section mothers.
Reproductive health and childbirthNorthern Ireland - Completed
Feasibility of conducting a randomised controlled trial (RCT) comparing invasive (catheter or needle) and non-invasive (clean catch/urine caught in a pot) urine sampling techniques in children under 16 years old with a suspected urinary tract infection
This study looks at the best way to collect urine samples from children under 16 with a suspected urine infection. We want to find out if it's possible to run a larger study comparing different methods, like catching urine in a pot or using a thin tube, to help doctors decide the safest and most effective way.
Urinary tract infectionNorthern Ireland - CompletedPhase I
Phase I trial: CA47303
This early-stage study, called CA47303, is looking for healthy women aged 18 to 45. It's designed to understand how a new investigational treatment works in the body and if it's safe. Details about the treatment will be made public later.
Healthy volunteersNorthern Ireland