- Active not recruitingPHASE2
A Comparison of Reduced Dose Total Body Irradiation (TBI) and Cyclophosphamide With Fludarabine and Melphalan Reduced Intensity Conditioning in Adults With Acute Lymphoblastic Leukaemia (ALL) in Complete Remission. (ALL-RIC)
This study compares two ways to prepare adults with acute lymphoblastic leukaemia (ALL) for a stem cell transplant. It aims to find out if a slightly stronger treatment can better stop the cancer from coming back, without making the transplant recovery harder.
For: Acute Lymphoblastic LeukemiaUnited Kingdom - RecruitingPHASE2
Nonmyeloablative Stem Cell Transplant in Children With Sickle Cell Disease and a Major ABO-Incompatible Matched Sibling Donor
This study looks into a new way of doing stem cell transplants for children aged 1 to 19 with sickle cell disease. It aims to make this life-changing treatment available to more children, especially if their donor's blood type doesn't perfectly match theirs.
For: Sickle Cell Disease · Stem Cell Transplant Complications · Red Blood Cell DisorderCanada - Active not recruitingPHASE2
Early Human Leukocyte Antigen (HLA) Matched Sibling Hematopoietic Stem Cell Transplantation
This study is for children under 13 with sickle cell disease who have a healthy sibling donor. It looks at a special type of bone marrow transplant to see if it's safe and effective, aiming to improve long-term health and quality of life for these children.
For: Sickle Cell DiseaseUnited States · Canada