All participants will follow a Total Diet Replacement (TDR) program providing ~800 kcal/day using commercially available clinical trials

Pancreas lipotoxicity in type 2 diabetes: Edinburgh Diabetes Remission Study (EDRS)

This study, the Edinburgh Diabetes Remission Study (EDRS), is looking at how fat in the pancreas affects type 2 diabetes. It wants to see if losing weight can reverse the condition. Participants will follow a special low-calorie diet to help researchers understand these changes.