- AuthorisedTherapeutic use (Phase IV)
Thromboprophylaxis with apixaban during neoadjuvant therapy for muscle-invasive bladder cancer (ACB): An international randomized controlled trial evaluating apixaban versus no anticoagulation in patients scheduled to undergo radical cystectomy or chemoradiotherapy for muscle-invasive bladder cancer
This clinical study looks at whether taking a blood-thinning tablet called apixaban can help prevent blood clots in people receiving treatment for bladder cancer before surgery or radiotherapy. Researchers want to see if this medicine safely stops blood clots forming without causing unwanted bleeding.
For: Venous thromboembolism (in bladder cancer patients)Finland - Active not recruitingPHASE3
A Study of Milvexian Versus Apixaban in Participants With Atrial Fibrillation
This study is comparing two medicines, milvexian and apixaban, for people with an irregular heartbeat called atrial fibrillation. We want to see if milvexian is just as good as apixaban at stopping serious problems like strokes, which can happen with this condition.
For: Atrial FibrillationUnited States · Argentina · Australia - RecruitingPHASE3
Thromboprophylaxis in Lower Limb Immobilisation
This study looks at new ways to prevent blood clots after a leg injury treated with a cast or splint. It compares injections with tablets and also checks if medication helps those at lower risk of clots. The goal is to find safer and more effective options.
For: Thrombosis · Injury LegUnited Kingdom - RecruitingPHASE4
THRomboprophylaxis in Individuals Undergoing Superficial endoVEnous Treatment (THRIVE)
This study looks at whether blood-thinning medicines can help prevent blood clots after common varicose vein operations. It aims to see if giving these medicines after keyhole procedures for varicose veins is a good idea to keep you safe.
For: Venous Thromboembolism · Varicose VeinsUnited Kingdom - RecruitingPHASE4
Dabigatran vs. Oral Anti-Xa Inhibitors in S. Aureus Bacteremia
This study compares different blood thinners (Dabigatran vs. Apixaban, Edoxaban, or Rivaroxaban) in people with a serious স্টাফ infection (S. aureus bacteremia). We want to see if switching to dabigatran, which might fight the infection, improves outcomes for patients already taking blood thinners.
For: Staphylococcus Aureus Endocarditis · Staphylococcus Aureus Septicemia · Staphylococcus Aureus BacteremiaCanada - Active not recruitingPHASE1
A Study to Investigate Andexanet Dosing and the Interaction Between Andexanet and Subsequent Enoxaparin in Healthy Participants
This study is testing a new medicine called Andexanet. It's for healthy people aged 18 to 55. We want to see how Andexanet works with common blood thinners like Rivaroxaban and Apixaban, and if it affects another blood thinner called Enoxaparin. This helps doctors understand how to use Andexanet safely.
For: Healthy ParticipantsGermany · United Kingdom - RecruitingPHASE3
Apixaban to Prevent Venous Thromboembolism in Ambulatory Lung Cancer Patients Undergoing Systemic Anticancer Treatment
This study looks at whether a tablet called apixaban can stop blood clots in people with lung cancer who are having chemotherapy. Blood clots can be a serious problem, and apixaban is a 'blood thinner' designed to reduce this risk.
For: ThromboprophylaxisUnited Kingdom - Active not recruiting
High Gastrointestinal Bleed Risk Outcomes in Patients With Non-valvular Atrial Fibrillation (NVAF) in France
This study looks back at French health records to understand how different blood-thinning medicines affect people with an irregular heartbeat (atrial fibrillation) who are at higher risk of stomach bleeding. It compares older medicines like warfarin with newer ones to see how safe and effective they are.
For: Atrial FibrillationUnited Kingdom - Active not recruiting
Anticoagulation in Patients With Venous Thromboembolism and Cancer
This study looks back at patient records to understand how different blood-thinning medicines work for people with cancer who have also had blood clots. It compares medicines like Apixaban, Rivaroxaban, and Dabigatran to see which are most effective and safe.
For: Neoplasms · EmbolismUnited Kingdom