- RecruitingPhase IV
Aspirin after hospitalisation with pneumonia to prevent heart attacks and stroke
Pneumonia can temporarily raise your risk of suffering a heart attack or stroke. The ASPECT clinical trial is testing whether taking a low dose of daily aspirin for three months after being hospitalised with pneumonia can help protect patients from these serious heart and blood circulation problems.
For: Pneumonia - lung infectionUnited Kingdom · England - CompletedNot Applicable
Finding the best dose of aspirin to prevent Lynch Syndrome cancers
This UK study looks at whether lower daily doses of aspirin can prevent cancer in people with Lynch syndrome just as well as higher doses. Lynch syndrome is an inherited condition that raises cancer risk. Researchers hope lower doses will offer strong protection with fewer stomach-related side effects.
For: Lynch syndromeUnited Kingdom · England - CompletedPhase IV
ATTACK: Aspirin to prevent a first heart attack or stroke in people with chronic kidney disease
Chronic kidney disease increases the risk of heart attacks and strokes. The ATTACK trial is testing whether taking a daily low-dose aspirin can help prevent a first heart attack or stroke in people with kidney disease, while checking that the benefits outweigh any risk of bleeding.
For: Chronic kidney disease (Stages 1-4)United Kingdom · England - Active not recruitingPHASE2
Aspirin in Preventing Disease Recurrence in Patients With Barrett Esophagus After Successful Elimination by Radiofrequency Ablation
This study looks at whether a daily low-dose aspirin can stop Barrett's oesophagus from coming back after successful treatment. We're also checking how safe aspirin is and tracking specific body markers that might show if the condition is returning.
For: Barrett Esophagus · Esophageal AdenocarcinomaUnited States · Canada - RecruitingPHASE4
Clopidogrel vs. Aspirin for Cardiovascular Risk Reduction in Patients With S. Aureus Bacteremia
This study looks at whether changing from aspirin to clopidogrel might help people with a specific blood infection called S. aureus bacteremia. We're studying patients who already take aspirin for heart or circulation problems.
For: Staphylococcus Aureus Endocarditis · Staphylococcus Aureus Septicemia · Staphylococcus Aureus Bloodstream InfectionCanada - RecruitingPHASE4
Monotherapy With P2Y12 Inhibitors in Patients With Atrial fIbrillation Undergoing Supraflex Stent Implantation
This study compares different ways to give blood-thinning medicines to people who have an irregular heartbeat (atrial fibrillation) and have had a heart stent fitted. It looks at whether using fewer medicines a bit sooner can be safer while still protecting the heart.
For: Percutaneous Coronary Intervention (PCI) · Atrial Fibrillation (AF) · Oral AnticoagulationBelgium · France · Germany - RecruitingPHASE3
Randomised Evaluation of COVID-19 Therapy
The RECOVERY trial looks at treatments for serious lung infections like pneumonia, including COVID-19. It helps doctors find the best ways to help hospitalised patients get better and reduce their risk of dying. Many treatments have been tested, and some have been found to be very helpful.
For: PneumoniaBelgium · Estonia · France - RecruitingPHASE3
Randomized, Embedded, Multifactorial Adaptive Platform Trial for Community- Acquired Pneumonia
This study, called REMAP-CAP, looks at different treatments for serious lung infections like pneumonia, flu, and COVID-19 in adults needing intensive care. It aims to find out which treatments work best to help patients recover.
For: Community-acquired Pneumonia, Influenza, COVID-19United States · Australia · Belgium - Active not recruitingPHASE4
ASCEND: A Study of Cardiovascular Events iN Diabetes
The ASCEND study looked at whether daily aspirin or omega-3 tablets could prevent serious heart problems and strokes in people with diabetes who hadn't had them before. It found aspirin helped but also increased bleeding. Omega-3s didn't make a difference.
For: Diabetes MellitusUnited Kingdom