- RecruitingTherapeutic exploratory (Phase II)
GFM-DACORAL-DLI: ASTX727 and donor lymphocyte infusions (DLI) after allogeneic stem cell transplantation (ALLO SCT) in very high-risk MDS or AML patients
This study looks at a new drug, ASTX727, with a special treatment called DLI for adults who have very risky forms of blood cancers (MDS or AML) after a stem cell transplant. The aim is to see if this combination helps people stay cancer-free for longer.
For: Patients with high risk myelodysplastic syndrome or acute myeloid leukemiaFrance - CompletedPhase II
A comparison of response to treatment in patients with Myelodysplastic Syndrome/Myeloproliferative Neoplasm (MDS/MPN) Overlap Syndromes taking ASTX727 versus best supportive care
This UK clinical trial is testing a new tablet called ASTX727 for adults with rare bone marrow cancers called MDS/MPN overlap syndromes. Researchers want to find out if taking this tablet at home works better at managing the condition and improving quality of life than standard supportive hospital care.
For: Myelodysplastic Syndrome/Myeloproliferative Neoplasm (MDS/MPN) Overlap SyndromesUnited Kingdom · England · Northern Ireland - Enrolling by invitationPHASE2
A Study for Participants Who Participated in Prior Clinical Studies of ASTX727 (Standard Dose)
This study is for people who are already taking a medicine called ASTX727 for certain blood cancers (like acute myeloid leukaemia, chronic myelomonocytic leukaemia, or myelodysplastic syndromes) in other studies, and it's helping them. It’s a way to keep taking the medicine and gather long-term safety information.
For: Acute Myeloid Leukemia · Chronic Myelomonocytic Leukemia · Myelodysplastic SyndromesUnited States · Armenia · Austria - Active not recruitingPHASE1
Combination Study of Guadecitabine/ASTX727 and Pembrolizumab
This study looks at combining two medicines, Guadecitabine/ASTX727 and Pembrolizumab, for people with advanced solid tumours, including a type of lung cancer. The main aim is to check if this new combination is safe and what doses work best.
For: Non Small Cell Lung CancerUnited Kingdom - RecruitingPHASE1
Lutathera and ASTX727 in Neuroendocrine Tumours
This study looks at a new way to treat neuroendocrine tumours. It checks if taking a medicine called ASTX727 before Lutathera helps Lutathera work better. Doctors will use special scans to see if this combination treatment improves how your body responds.
For: Neuroendocrine TumorsUnited Kingdom