- RecruitingPHASE3
Active Surveillance, Bleomycin, Etoposide, Carboplatin or Cisplatin in Treating Pediatric and Adult Patients With Germ Cell Tumors
This study looks at how best to treat a type of cancer called germ cell tumours in children and adults. It compares simply watching the tumour after surgery with different chemotherapy treatments to see which works best and causes fewer side effects.
For: Childhood Extracranial Germ Cell Tumor · Extragonadal Embryonal Carcinoma · Germ Cell TumorUnited States · Australia · Canada - Active not recruitingPHASE1
Testing the Combination of Anetumab Ravtansine With Either Nivolumab, Nivolumab and Ipilimumab, or Gemcitabine and Nivolumab in Advanced Pancreatic Cancer
This study tests new ways to treat advanced pancreatic cancer. It combines a targeted drug (anetumab ravtansine) with immune-boosting medicines (nivolumab, ipilimumab) and standard chemotherapy (gemcitabine) to see if these combinations are safe and effective.
For: Pancreatic Adenocarcinoma · Stage II Pancreatic Cancer AJCC v8 · Stage III Pancreatic Cancer AJCC v8United States · Canada - RecruitingPHASE1
Studying the Safety and Determining the Optimal Dose of Novobiocin in Patients With Tumors That Have Alterations in DNA Repair Genes
This study is testing a new drug called novobiocin for people with advanced cancers that have specific gene changes. We want to find out the safest dose and if it can help shrink or control cancer by stopping it from repairing damaged DNA.
For: Metastatic Malignant Solid Neoplasm · Unresectable Malignant Solid NeoplasmUnited States · Canada - RecruitingPHASE2
A Study Using Nivolumab, in Combination With Chemotherapy Drugs to Treat Nasopharyngeal Carcinoma (NPC)
This study looks at combining nivolumab, an immunotherapy drug, with chemotherapy and then radiation for young people with nasopharyngeal cancer. Researchers want to see if this new treatment can fight the cancer effectively, understand its side effects, and potentially reduce radiation for children.
For: Stage II Nasopharyngeal Carcinoma AJCC v8 · Stage III Nasopharyngeal Carcinoma AJCC v8 · Stage IV Nasopharyngeal Carcinoma AJCC v8United States · Canada · New Zealand - Active not recruitingPHASE2
Testing Ipilimumab and Nivolumab Combination With or Without Cabozantinib in People >= 18 Years Old With Advanced Soft Tissue Sarcoma
This study looks at treating advanced soft tissue sarcoma with a combination of two immunotherapy drugs (ipilimumab and nivolumab), alone or with an additional drug called cabozantinib, to see which works best.
For: Locally Advanced Extraskeletal Myxoid Chondrosarcoma · Locally Advanced Leiomyosarcoma · Locally Advanced LiposarcomaUnited States · Canada - Active not recruitingPHASE2
Cabozantinib S-malate and Nivolumab in Treating Patients With Advanced, Recurrent, or Metastatic Endometrial Cancer
This study looks at new treatments for advanced endometrial cancer that has come back or spread. It tests if combining two drugs, cabozantinib and nivolumab, works better than nivolumab alone to shrink cancer and help people live longer. This could offer new hope for patients.
For: Advanced Endometrial Carcinoma · Metastatic Endometrial Carcinoma · Recurrent Endometrial CarcinomaUnited States · Canada - RecruitingPHASE2
MYELOMATCH: A Screening Study to Assign People With Myeloid Cancer to a Treatment Study or Standard of Care Treatment Within myeloMATCH (MyeloMATCH Screening Trial)
This study helps doctors find the best treatments for people with certain blood cancers like leukaemia. It uses special tests on blood and bone marrow to match patients with personalised treatments or standard care, aiming to improve how cancer treatments are chosen.
For: Acute Myeloid Leukemia · Acute Myeloid Leukemia Arising From Previous Myelodysplastic/Myeloproliferative Neoplasm · Acute Myeloid Leukemia Post Cytotoxic TherapyUnited States · Canada · Puerto Rico - Active not recruitingPHASE2
Testing Atezolizumab in People 2-17 Years Old With Clear Cell Sarcoma or Advanced Chondrosarcoma
This study is testing a new medicine, Atezolizumab, for children and young people aged 2 to 17 with certain types of rare cancers: clear cell sarcoma or chondrosarcoma. It aims to see how well the medicine helps the body's immune system fight the cancer.
For: Central Chondrosarcoma, Grade 2 · Central Chondrosarcoma, Grade 3 · Dedifferentiated ChondrosarcomaUnited States · Canada - Active not recruitingPHASE2
Gemcitabine Hydrochloride and Cisplatin With or Without Veliparib or Veliparib Alone in Treating Patients With Locally Advanced or Metastatic Pancreatic Cancer
This study looks at new ways to treat pancreatic cancer that has spread. It compares standard chemotherapy with or without a new drug called veliparib. We're testing if adding veliparib helps stop cancer growth, especially in people with specific genetic changes.
For: Locally Advanced Pancreatic Adenocarcinoma · Metastatic Pancreatic Adenocarcinoma · Stage III Pancreatic Cancer AJCC v8United States · Canada · Israel - RecruitingPHASE3
Chemotherapy for the Treatment of Patients With Newly Diagnosed Very Low-Risk and Low Risk Fusion Negative Rhabdomyosarcoma
This study is giving children and young adults with a type of soft tissue cancer called rhabdomyosarcoma new chemotherapy. It aims to see if less harsh treatment works for those with very low-risk cancer, and if standard treatment works well for others, while also studying patients with specific genetic changes.
For: Embryonal Rhabdomyosarcoma · Fusion-Negative Alveolar Rhabdomyosarcoma · Spindle Cell/Sclerosing RhabdomyosarcomaUnited States · Australia · Canada - Active not recruitingPHASE2
Testing the Combination of Two Anticancer Drugs M1774 (Tuvusertib) and Avelumab to Evaluate Their Safety and Effectiveness in Treating Merkel Cell Skin Cancer, MATRiX Trial
This study looks at combining two cancer drugs, tuvusertib and avelumab, for people with advanced Merkel cell skin cancer that hasn't responded to previous treatment. It aims to see if the combination works better than tuvusertib alone to stop the cancer from getting worse.
For: Clinical Stage III Cutaneous Merkel Cell Carcinoma AJCC v8 · Clinical Stage IV Cutaneous Merkel Cell Carcinoma AJCC v8 · Locally Advanced Merkel Cell CarcinomaUnited States · Canada