- Recruiting
Multimodal Biomarkers in Coronary Artery Disease Pathogenesis: The Oxford Acute Myocardial Infarction Study (OXAMI Study)
The OXAMI Study aims to understand why some heart artery problems become serious. Researchers will look at heart arteries, blood flow, and heart muscle damage, using imaging and blood tests. The goal is to find better ways to predict, diagnose, and treat heart conditions, improving care for future patients.
For: Myocardial Injury · Atherosclerosis Cardiovascular Disease · Cardiac Imaging TechniquesUnited Kingdom - RecruitingNA
Skeletal Muscle Adaptations to Peptide-Supplemented Resistance Exercise Training
This study looks at whether a special daily supplement, combined with weight training, can help people aged 18-35 build more muscle and get stronger. We want to see if this supplement works better than a dummy pill (placebo).
For: Supplement · Resistance Training AdaptationUnited Kingdom - Recruiting
CYSTEA-BONE Clinical Study
This study looks at how a medicine called cysteamine affects bone health in children and adults with a rare kidney condition called nephropathic cystinosis. We want to understand why some patients develop bone problems and how their genes might play a role.
For: Nephropathic CystinosisFrance · Germany · Italy - Recruiting
Characterisation of Intestinal Microbiota of Patients With Spondyloarthritis or Rheumatoid Arthritis
This study looks at the gut bacteria in people with spondyloarthritis or rheumatoid arthritis to see if it's different from healthy people. Researchers want to understand if specific gut bacteria are linked to these conditions and could help find new ways to detect or treat them.
For: Spondyloarthritis · Rheumatoid ArthritisFrance - Recruiting
Thrombo-inflammation Biomarkers Trial in Acute Cerebral Hypoxia
Researchers are studying whether certain blood markers can help us understand brain damage caused by a lack of oxygen. This study compares these markers in people with serious brain conditions to those with milder, temporary problems, to see how they link to recovery.
For: Cerebral Hypoxia · Ischemic StrokeFrance - RecruitingNA
Interaction Between Host, Microenvironment and Immunity on Gastrointestinal Neoplasms
This study looks at how your body, its tiny environment, and your immune system affect digestive cancers like bowel or pancreatic cancer. Researchers want to understand these connections to improve treatments and predict patient outcomes.
For: Gastrointestinal NeoplasmsFrance - Not yet recruitingNA
Search for Circulating Tumour Cells in the Blood and/or Cerebrospinal Fluid in Patients With Recurrent Aggressive Meningiomas: Proof-of-concept Study
This study looks for tiny cancer cells in blood and spinal fluid of people with aggressive meningioma, a type of brain tumour. It aims to see if these cells can help diagnose or track the tumour without needing surgery.
For: MeningiomaFrance - RecruitingNA
EDN and Eosinophilic Esophagitis
This study looks for easier ways to check on children with Eosinophilic Oesophagitis (EoE), a condition causing food pipe inflammation. Researchers hope to find new tests using blood, urine, and saliva instead of frequent endoscopies to see how the disease is doing.
For: Eosinophilic EsophagitisFrance - RecruitingNA
Prospective Multicenter Cohort Study to Validate Four Groups of Biomarkers for Assessing Lung Cancer Risk Among Patients With Atheromatous Cardiovascular Disease in a Screening Pathway
This study looks for early signs of lung cancer in people at risk, especially those with heart disease linked to smoking. They'll use blood and stool samples, along with special X-rays, to find new ways to detect cancer sooner and help people stop smoking.
For: Smoking-related Pathology · Atheroma · Non-progressive Cancer > 5 YearsFrance - RecruitingNA
Mechanisms of Resistance to Amivantamab in Patients With NSCLC With EGFR Exon 20 Insertion
This study looks at why a lung cancer treatment, amivantamab, stops working for some patients with a specific type of lung cancer (NSCLC with EGFR exon 20 insertion). We collect blood and tissue samples to understand these reasons better.
For: Non-small Cell Lung Cancer · EGFR Exon 20 Insertion MutationFrance - Recruiting
Screening for Prognostic Biomarkers of Severe Bell's Palsy in Adults
This study looks for clues in your blood to predict how severe Bell's palsy, a type of facial paralysis, might be. We want to find out early who might need more treatment to fully recover and avoid long-term problems, helping doctors make the best decisions sooner.
For: Bell PalsyFrance - Active not recruitingNA
Circulating Tumor DNA for the Early Detection of HPV-positive Pelvic Cancer Relapses (CIRCA-HPV)
This study looks for tiny bits of cancer DNA in blood to spot if HPV-related pelvic cancers come back early. It follows people who've already been treated for these cancers to see if this new blood test can find problems sooner.
For: HPV Positive Pelvic CancerFrance - Recruiting
Biobank for Inflammatory Chronic Diseases and Osteoporosis
This study aims to create a collection of blood samples from people with certain types of arthritis (rheumatoid, psoriatic, spondyloarthritis) or osteoporosis. Researchers hope to find markers in the blood that can help doctors choose the best treatments for these conditions.
For: Rheumatoid Arthritis · Psoriatic Arthritis · SpondyloarthritisFrance - RecruitingEARLY_PHASE1
B-GLUCANCER2 : A Pilot Study Evaluating a New Method for Cancer Detection by Measuring the Activity of Different Glycosidase Enzymes in the Plasma of Patients With a Localized Cancer.
This study aims to find a new way to detect cancer early using a simple blood test. Researchers are looking for tiny clues called 'glycosidases' in blood plasma that might show if someone has breast, lung, or pancreatic cancer, and how well treatments are working.
For: Breast Cancer · Pancreatic Cancer · Pulmonary CancerFrance - Recruiting
Clinico-biological Collection of Autoimmune, Dysimmune or Auto-inflammatory Dermatological Diseases
This study aims to collect information and samples from people with certain skin diseases caused by their immune system. This will help scientists better understand these conditions, find new ways to diagnose them, and develop improved treatments for the future.
For: Autoimmune Bullous Dermatosis · Dysimmune Dermatological Diseases · Auto-inflammatory Dermatological DiseasesFrance - Recruiting
Metagenomic Analysis of Bacterial Microbiota in Breast Milk
This study looks at tiny living things, called bacteria, in breast milk. Researchers want to understand if these bacteria could cause problems for premature babies and how different types of bacteria in milk compare to those linked to infections.
For: Bacteria in Breast MilkFrance - RecruitingNA
Blood Clearance Kinetics of the Nucleosome and CTCF in Peritoneal Metastasis Colorectal Cancer.
This study looks at new blood tests for bowel cancer that has spread to the tummy lining. We want to see how quickly these markers clear from the blood after surgery, helping doctors check if all cancer cells have been removed.
For: Peritoneal Carcinomatosis · Peritoneal Metastases From Colorectal CancerFrance - RecruitingNA
Investigation of AlzHeimer's Predictors in Subjective Memory Complainers - Extension Study
This study is looking into how Alzheimer's disease develops in people who have noticed changes in their memory. It involves following people who were part of a previous study for several more years to see if they develop Alzheimer's.
For: Alzheimer Disease · Memory Complaint · Memory DisordersFrance - RecruitingNA
Insulin Resistance in Multiple System Atrophy
This study is looking into why people with Multiple System Atrophy (MSA) might have problems with how their bodies use insulin, even if they don't have diabetes. Researchers want to see if these insulin problems in the brain and body play a role in MSA, aiming to find new ways to treat the condition in the future.
For: Multiple System AtrophyFrance - RecruitingNA
Fetal Cell Receptors Repertoire
This study looks at special cells from pregnancy that stay in a mother's body. We want to see how these cells help heal skin wounds like leg ulcers after childbirth. We'll compare cells from women with ulcers to those without, to understand how healing works.
For: Venous Ulcer · Sickle Cell Ulcer · Diabetic UlcerFrance - Recruiting
The Value of Measuring Retinal Vascular Density by Optical Coherence Tomography-Angiography (OCT-A) in Patients With Microvascular Angina Confirmed by Myocardial Microcirculatory Resistance Index (MRI).
This study looks at a new, simple eye scan to help diagnose a heart condition called microvascular angina (MVA). MVA causes chest pain but doesn't show up on standard heart scans. Researchers are comparing the eye scan results with current, more invasive heart tests to see if it could be a useful, easier diagnostic tool.
For: Microvascular AnginaFrance - Recruiting
Septic Shock-induced Immunosuppression
This study looks for better ways to spot and treat a serious problem called sepsis-induced immunosuppression. This happens when the body's infection-fighting system (immune system) becomes very weak after a severe infection, making people vulnerable to new infections.
For: Septic ShockFrance - RecruitingNA
Characterization and Support for Neurodevelopmental Disorders Associated With Congenital Heart Defects
This study looks at how heart problems from birth (congenital heart defects) can affect a child's development. Researchers want to find these developmental differences early, ideally by age 3, and understand why some children are more affected than others.
For: Congenital Heart Defects · Neurodevelopmental DisorderFrance - Recruiting
AI-driven Narrow-band Imaging Score for Disease Assessment and Outcome Prediction in Ulcerative Colitis
This study aims to create a new, simple way to check how active Ulcerative Colitis is using special camera tests (colonoscopies). It will also explore using artificial intelligence to make these checks more accurate and help predict how the disease might progress over time.
For: Ulcerative Colitis (UC)Belgium · Germany · Ireland - Recruiting
DERMATOMICS: Identifying Regulators of Skin Homeostasis
This study, DERMATOMICS, aims to better understand severe skin conditions like scleroderma (Systemic Sclerosis). Researchers will look at skin and blood samples to find new ways to treat these conditions and improve the lives of those affected. It focuses on the causes and ways to improve treatment.
For: Systemic Sclerosis (SSc)United Kingdom - Active not recruiting
Network Of Clinical Research Studies On Craniosynostosis, Skull Malformations With Premature Fusion Of Skull Bones
This study looks into craniosynostosis, a condition where a baby's skull bones join too early. We want to understand what causes it, especially the coronal type, by studying genes and other factors. This could lead to better treatments for kids with this condition.
For: CraniosynostosisUnited States · France · Germany