- Recruiting
A Non-interventional Study of Participants With BPDCN Treated With Chemotherapy
This study looks at how chemotherapy treatments work for adults in the UK with a rare blood cancer called BPDCN. It aims to understand how safe and effective these treatments are in real-world settings, helping doctors compare them with new drug studies.
For: Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN)Denmark · France · Germany - Active not recruitingPHASE3
Quizartinib or Placebo Plus Chemotherapy in Newly Diagnosed Patients With FLT3-ITD Negative AML
This study is looking at a new drug, quizartinib, combined with standard chemotherapy for adults recently diagnosed with a specific type of leukaemia called AML. We want to see if this combination improves treatment outcomes compared to chemotherapy alone.
For: LeukemiaUnited States · Australia · Austria - RecruitingPHASE3
Study of TDXd, Chemotherapy, Pembrolizumab, and Trastuzumab in First-Line Metastatic HER2-Positive Gastric or Gastroesophageal Junction Cancer
This study looks at new drug combinations for stomach or food pipe cancer that has spread. It compares an experimental treatment with standard care, aiming to find better ways to treat patients whose cancer has specific features.
For: Gastric Cancer · Gastroesophageal Junction CancerUnited States · Argentina · Australia - RecruitingPHASE3
A Randomized Phase III Trial of Stereotactic Ablative Radiotherapy for Patients With Up to 10 Oligometastases and a Synchronous Primary Tumor.
This study looks at a special type of strong radiation, called SABR, for people with a few small cancer spots that have spread, along with a main tumor. It compares SABR plus usual care to just usual care to see if it helps.
For: Metastatic TumorCanada · Switzerland - RecruitingPHASE3
Minimally Invasive Surgery After Neoadjuvant Chemotherapy for the Treatment of Stage IIIC-IV Ovarian, Primary Peritoneal, or Fallopian Tube Cancer, LANCE Trial
This study compares keyhole surgery (minimally invasive surgery) with traditional open surgery (laparotomy) for advanced ovarian cancer. It's for women who've already had chemotherapy. The aim is to see if keyhole surgery is as good or better for recovery and quality of life.
For: Advanced Ovarian Carcinoma · Fallopian Tube Clear Cell Adenocarcinoma · Fallopian Tube Endometrioid TumorUnited States · Canada · Italy - Active not recruitingPHASE2
Radiochemotherapy +/- Durvalumab for Locally-advanced Anal Carcinoma. a Multicenter, Randomized, Phase II Trial of the German Anal Cancer Study Group
This study is testing if adding a drug called durvalumab to standard treatment (chemotherapy and radiation) works better for advanced anal cancer. Researchers want to see if this new combination improves how well people respond to treatment.
For: Anal Cancer · Anal Carcinoma · Anal Cancer Stage IIIAustria · Germany · Switzerland - RecruitingPHASE3
Study of Trastuzumab Deruxtecan Versus Standard of Care Chemotherapy for HER2-Expressing (IHC 3+/2+) Endometrial Cancer
This study compares a new drug, trastuzumab deruxtecan, with standard chemotherapy for women with early-stage HER2-positive womb cancer. It aims to see which treatment works better after surgery to stop the cancer from coming back.
For: Endometrial CancerUnited States · Argentina · China - RecruitingPHASE3
Study on the Efficacy of Treatment by Radiotherapy and Pembrolizumab in Newly Diagnosed Metastatic Head & Neck Cancers
This study looks at new ways to treat advanced head and neck cancer. It combines radiotherapy and a drug called pembrolizumab, sometimes with chemotherapy, to see if it works better than standard treatments for newly diagnosed patients.
For: Squamous Cell Carcinoma of Head and NeckFrance - Active not recruitingPHASE2
Postoperative Immunotherapy vs Standard Chemotherapy for Gastric Cancer With High Risk for Recurrence
This study compares two treatments for stomach or food pipe cancer that has a high chance of coming back after surgery. It's looking at whether a new immunotherapy combination works better than standard chemotherapy to prevent the cancer from returning.
For: Gastric and Esophagogastric Junction AdenocarcinomaCzechia · France · Germany - Active not recruitingPHASE1, PHASE2
Phase 1/2 Study Evaluating MCLA-129, a Human Anti-EGFR, Anti-c-MET Bispecific Antibody, in Advanced NSCLC and Other Solid Tumors, Alone and in Combination
This study is looking into a new drug, MCLA-129, for some advanced cancers like lung or stomach cancer. It will see how safe and effective it is, both by itself and with other treatments. It's for people who haven't responded to previous treatments.
For: Non-Small Cell Lung Cancer Metastatic · Gastric Cancer · Esophageal Squamous Cell CarcinomaUnited States · Belgium · France - RecruitingPHASE3
Symbiotic-GI-03: A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Adult Participants With Metastatic Colorectal Cancer
This study is testing a new medicine, PF-08634404, alongside standard chemotherapy for adults with colorectal cancer that has spread. We want to see if this new combination helps more than an existing treatment with chemotherapy for people whose cancer has returned or spread.
For: Intestinal Neoplasms · Gastrointestinal Neoplasms · Digestive System NeoplasmsUnited States · Argentina · Australia - RecruitingPHASE2, PHASE3
An International Clinical Program for the Diagnosis and Treatment of Children With Ependymoma
This study aims to improve treatment and understanding of childhood ependymoma. It involves different treatment approaches, including chemotherapy and radiotherapy, for children and young adults up to 22 years old. The goal is to find better ways to help these patients.
For: Childhood EpendymomaAustria · Belgium · Czechia - Active not recruitingPHASE2
Stereotactic Radiotherapy Combined With Chemotherapy or Not for Treatment of Oligometastases in HNSCC
This study looks at treating head and neck cancer that has spread a little, comparing powerful X-ray treatment (stereotactic radiotherapy) alone or with chemotherapy. We're checking how people feel, their quality of life, and if there are fewer side effects.
For: Head and Neck Squamous Cell CarcinomaFrance - Active not recruitingPHASE3
Stereotactic Ablative Radiotherapy for Comprehensive Treatment of 4-10 Oligometastatic Tumors
This study looks at a special type of radiation (SABR) for people with cancer that has spread a little (4-10 spots). It compares SABR to usual treatments to see if it helps people live longer, keeps cancer away, and improves their quality of life.
For: Metastatic TumorsAustralia · Canada · Netherlands - RecruitingPHASE2, PHASE3
Refining Adjuvant Treatment IN Endometrial Cancer Based On Molecular Features
This study looks at new treatments for endometrial cancer based on specific cancer features. It aims to find better ways to treat patients after surgery, potentially leading to personalised care for different types of endometrial cancer.
For: Endometrial CancerCanada · France · Netherlands - Active not recruitingPHASE3
Bemarituzumab Plus Chemotherapy and Nivolumab Versus Chemotherapy and Nivolumab for FGFR2b Overexpressed Untreated Advanced Gastric and Gastroesophageal Junction Cancer.
This study looks at a new drug, bemarituzumab, in combination with standard chemotherapy and nivolumab for advanced stomach or food pipe cancer. It aims to see if this new combination is safe and works better than current treatments, helping people with specific types of cancer live longer.
For: Gastric Cancer · Gastroesophageal Junction AdenocarcinomaUnited States · Argentina · Australia