- Active not recruitingPHASE3
A Study of Oral Asciminib Versus Other TKIs in Adult Patients With Newly Diagnosed Ph+ CML-CP
This study looks at a new medicine called asciminib for adults with a type of blood cancer called CML. Researchers want to see if it works better than other standard CML treatments. It's for people recently diagnosed who haven't had treatment yet.
For: Chronic Myeloid Leukemia (CML) Philadelphia Chromosome PositiveUnited States · Australia · Austria - RecruitingPHASE4
Asciminib Roll-over Study
This study is for people who have already been taking a medicine called asciminib (or similar drugs) in a Novartis study for a type of blood cancer called CML. It allows them to keep taking the medicine if their doctor thinks it's still helping them.
For: Chronic Myelogenous Leukemia · Leukemia, Myelogenous, Chronic, BCR-ABL PositiveUnited States · Argentina · Austria - RecruitingEARLY_PHASE1
Pilot Trial for Treatment of Recurrent Glioblastoma
This early trial aims to test new, personalised treatments for people with an aggressive type of brain tumour called glioblastoma that has come back. It will check if these treatments are safe and if this type of study can be done on a larger scale.
For: Glioblastoma · Recurrent Disease · Recurrent GlioblastomaCanada - Active not recruitingPHASE3
Treatment of Newly Diagnosed Acute Lymphoblastic Leukemia in Children and Adolescents
This study looks at new ways to treat childhood acute lymphoblastic leukemia (ALL). It explores how to choose the right treatment strength for each child and tests a new way to give a common chemotherapy drug called pegaspargase.
For: Acute Lymphoblastic Leukemia, PediatricUnited States · Canada - Active not recruitingPHASE1
A Study to Investigate the Safety and Efficacy of KQB198 as Monotherapy and in Combination in Participants With Advanced Hematologic Malignancies
This study is looking into a new treatment called KQB198 for blood cancers in adults. Researchers want to see if KQB198 is safe and if it can help shrink tumours, either by itself or with another medicine. They are also trying to find the best dose.
For: Hematologic Malignancies · AdultUnited States · France · Germany - Ongoing, recruitingTherapeutic exploratory (Phase II)
Senolytics to Improve Osteoporosis therapy: A randomised controlled clinical trial The SENIOR Trial
This study, called THE SENIOR Trial, is looking into a new treatment for weak bones (osteopenia and osteoporosis). It investigates if a medicine called DASATINIB can improve bone health by slowing down bone breakdown. We're measuring changes in a blood marker of bone breakdown after 21 weeks.
For: osteopenia, OsteoporosisDenmark - Active not recruitingPHASE2
Imatinib Mesylate or Dasatinib in Treating Patients With Previously Untreated Chronic Phase Chronic Myelogenous Leukemia
This study looks at two medicines, imatinib and dasatinib, for people with a type of blood cancer called chronic myeloid leukaemia (CML) who haven't been treated before. It aims to see which medicine works best at different doses.
For: Chronic Myeloid Leukemia, BCR-ABL1 PositiveUnited States · Canada - RecruitingPHASE1, PHASE2
HEM-iSMART-B: Dasatinib + Venetoclax + Dexamethasone + Cyclophosphamide and Cytarabine in Pediatric Patients With Relapsed or Refractory Hematological Malignancies
This study is for children and young adults aged 1-21 with specific types of aggressive blood cancers that have come back or not responded to treatment. It tests new drug combinations to see if they're safe and work well for those with certain genetic changes in their cancer.
For: Acute Lymphoblastic Leukemia · Lymphoblastic Lymphoma (Precursor B-Lymphoblastic Lymphoma/Leukaemia) Recurrent · Lymphoblastic Lymphoma (Precursor T-Lymphoblastic Lymphoma/Leukaemia) RecurrentAustria · Belgium · Denmark