- Active not recruitingPHASE3
A Study of Encorafenib Plus Cetuximab With or Without Chemotherapy in People With Previously Untreated Metastatic Colorectal Cancer
This study looks at new drug combinations for advanced bowel cancer that has spread and has a specific gene change (BRAF). It compares these new combinations with standard chemotherapy to see which works best for people who haven't had treatment for their spread cancer.
For: NeoplasmsUnited States · Argentina · Australia - Active not recruitingPHASE2
Binimetinib and Encorafenib for the Treatment of Advanced Solid Tumors With Non-V600E BRAF Mutations
This study looks at new drug combinations, binimetinib and encorafenib, for people with advanced cancers. It focuses on specific gene changes (BRAF mutations) that haven't responded to other treatments, aiming to see how well these drugs shrink tumors.
For: Solid TumorCanada - Active not recruitingPHASE3
A Clinical Trial of Three Study Medicines (Encorafenib, Binimetinib, and Pembrolizumab) in Patients With Advanced or Metastatic Melanoma
This study is looking at three new medicines for advanced melanoma, a type of skin cancer. It aims to see if combining these medicines helps people with melanoma that has spread and has a specific gene change called 'BRAF'.
For: MelanomaUnited States · Argentina · Austria - RecruitingPHASE3
Personalized Medicine for Advanced Biliary Cancer Patients
This study looks at whether adding a special "targeted" drug after initial treatment for advanced bile duct cancer works better than continuing standard treatment. It customises treatment based on your tumour's unique features.
For: Biliary Tract NeoplasmsBelgium · France · United Kingdom - Active not recruitingPHASE2
A Study of Encorafenib Plus Cetuximab Taken Together With Pembrolizumab Compared to Pembrolizumab Alone in People With Previously Untreated Metastatic Colorectal Cancer
This study looks at combining three medicines for advanced bowel cancer that has spread. It compares a new combination therapy (encorafenib, cetuximab, and pembrolizumab) with pembrolizumab alone for patients who haven't had treatment yet and have specific gene changes.
For: Metastatic Colorectal CancerUnited States · Australia · Belgium - Recruiting
BRAF Inhibitor Encorafenib And Cetuximab Real Life Investigation of Next Generation CRC Treatment
This study looks at how a specific treatment (encorafenib and cetuximab) works in real life for advanced bowel cancer with a particular gene change (BRAFV600E mutation). It also checks quality of life, safety, and how well it's tolerated in everyday use.
For: Metastatic Colorectal CarcinomaAustria · Germany - Recruiting
Binimetinib Plus Encorafenib Real Life Investigation of Next Generation Melanoma Treatment
This study looks at how well two medicines, encorafenib and binimetinib, work together for people with a specific type of advanced melanoma. It also checks on side effects and how it affects quality of life in everyday healthcare, outside of a strict clinical trial setting.
For: Melanoma Stage IV · Melanoma Stage IIIAustria · Germany · Switzerland