- RecruitingPHASE2, PHASE3
A Study to Evaluate the Safety and Efficacy of Pumitamig in Combination With Chemotherapy Versus Bevacizumab in Combination With Chemotherapy in Participants With Previously Untreated, Unresectable, or Metastatic Colorectal Cancer
This study is looking at a new treatment called pumitamig, combined with chemotherapy, for people with advanced bowel cancer that hasn't been treated before. It's being compared to a standard treatment, bevacizumab with chemotherapy, to see which is safer and more effective.
For: Untreated, Unresectable, or Metastatic Colorectal CancerUnited States · Argentina · Australia - RecruitingPHASE1
A Study Evaluating the Safety and Efficacy of Targeted Therapies in Subpopulations of Patients With Metastatic Colorectal Cancer (INTRINSIC)
This study looks at new treatments for bowel cancer that has spread. We want to see if these targeted medicines or immunotherapy are safe and work well for people whose cancer has specific genetic features, which we call biomarkers.
For: Metastatic Colorectal CancerUnited States · Australia · Canada - RecruitingPHASE1, PHASE2
Phase 1/2 Trial of S241656 in Selected RAS/MAPK Mutation- Positive Malignancies
This study is testing a new medicine called S241656 for people with certain advanced cancers, including lung, bowel, and pancreatic cancers. It aims to find a safe and effective dose, either alone or with other treatments, for cancers with specific genetic changes.
For: Non-small Cell Lung Cancer · Histiocytic Neoplasm · HistiocytosisUnited States · Denmark · Hong Kong - RecruitingPHASE1
A Study to Evaluate the Safety of INCA33890 in Participants With Advanced or Metastatic Solid Tumors
This study is testing a new medicine, INCA33890, for people with advanced or spreading solid cancers. Doctors want to see how safe the medicine is, what side effects it causes, and find the best dose to give.
For: Solid Tumors · Advanced Solid Tumors · Metastatic Solid TumorsUnited States · Denmark · France - RecruitingPHASE3
Post-resection/Ablation Chemotherapy in Patients With Metastatic Colorectal Cancer (FIRE-9 - PORT / AIO-KRK-0418)
This study looks at adding chemotherapy after surgery for advanced bowel cancer that has spread. We want to see if extra treatment improves how long people stay well and their quality of life, compared to just regular check-ups.
For: Colorectal CancerGermany - RecruitingPHASE1
A Study to Evaluate INCB161734 in Participants With Advanced or Metastatic Solid Tumors With KRAS G12D Mutation
This study is looking at a new treatment called INCB161734 for advanced cancers with a specific genetic change (KRAS G12D mutation). Researchers want to see if it's safe and how well it works, either alone or with other cancer drugs.
For: Solid TumorsUnited States · Australia · Belgium