- RecruitingPHASE3
A Study to Evaluate the Efficacy and Safety of Standard-of-Care Chemotherapy and Bevacizumab With or Without INCA33890 in the First-Line Treatment of Metastatic Microsatellite Stable Colorectal Cancer
This study is testing a new drug (INCA33890) alongside standard chemotherapy and another medicine (bevacizumab) for advanced bowel cancer that has spread. It aims to see if adding INCA33890 is safe and helps people live longer and feel better.
For: CRC (Colorectal Cancer)United States · Argentina · Australia - RecruitingPHASE1, PHASE2
CR-001 in Adult Participants With Locally Advanced or Metastatic Solid Tumors
This study is testing a new drug, CR-001, for adults with advanced or spreading solid cancers. The main goals are to find out if it's safe, what dose works best, and how well it's tolerated. It's an early-stage study looking for new treatment options.
For: Locally Advanced / Metastatic Solid TumorsUnited States · Australia · France - RecruitingPHASE3
Study of Perioperative Dostarlimab in Participants With Untreated T4N0 or Stage III dMMR/MSI-H Resectable Colon Cancer
This study looks at a new treatment called dostarlimab for certain types of colon cancer that haven't spread. It compares dostarlimab with standard treatments to see if it works better before and after surgery to help patients.
For: Colonic Neoplasms · Neoplasms, ColonUnited States · Argentina · Australia - RecruitingPHASE2
Novel Combinations in Participants With Locally Advanced Unresectable or Metastatic Gastric or Gastroesophageal Junction Adenocarcinoma
This study is testing new combinations of medicines for advanced stomach or food pipe cancer that has spread or can't be removed by surgery. It aims to see how well they work and if they are safe. Researchers want to find better ways to treat this type of cancer.
For: Gastric CancerUnited States · China · Japan - RecruitingPHASE1
A Study Evaluating the Safety and Efficacy of Targeted Therapies in Subpopulations of Patients With Metastatic Colorectal Cancer (INTRINSIC)
This study looks at new treatments for bowel cancer that has spread. We want to see if these targeted medicines or immunotherapy are safe and work well for people whose cancer has specific genetic features, which we call biomarkers.
For: Metastatic Colorectal CancerUnited States · Australia · Canada - RecruitingPHASE2, PHASE3
A Study to Evaluate the Safety and Efficacy of Pumitamig in Combination With Chemotherapy Versus Bevacizumab in Combination With Chemotherapy in Participants With Previously Untreated, Unresectable, or Metastatic Colorectal Cancer
This study is looking at a new treatment called pumitamig, combined with chemotherapy, for people with advanced bowel cancer that hasn't been treated before. It's being compared to a standard treatment, bevacizumab with chemotherapy, to see which is safer and more effective.
For: Untreated, Unresectable, or Metastatic Colorectal CancerUnited States · Argentina · Australia - RecruitingPHASE2, PHASE3
A Study to Evaluate the Safety and Efficacy of Pumitamig in Combination With Chemotherapy Versus Nivolumab in Combination With Chemotherapy in Participants With Previously Untreated Advanced or Metastatic Gastric, Gastroesophageal Junction, or Esophageal Adenocarcinoma (ROSETTA Gastric-204)
This study looks at new drug Pumitamig with chemotherapy, or Nivolumab with chemotherapy, for advanced stomach, gastroesophageal junction, or oesophageal cancer. It aims to see how safe and effective these combinations are for people who haven't had treatment for their advanced cancer.
For: Untreated Advanced or Metastatic Gastric, Gastroesophageal Junction, or Esophageal AdenocarcinomaUnited States · Argentina · Australia - RecruitingPHASE1
A Study to Evaluate the Safety of INCA33890 in Participants With Advanced or Metastatic Solid Tumors
This study is testing a new medicine, INCA33890, for people with advanced or spreading solid cancers. Doctors want to see how safe the medicine is, what side effects it causes, and find the best dose to give.
For: Solid Tumors · Advanced Solid Tumors · Metastatic Solid TumorsUnited States · China · Denmark - Active not recruitingPHASE1, PHASE2
COLUMBIA-1: Novel Oncology Therapies in Combination With Chemotherapy and Bevacizumab as First- Line Therapy in MSS-CRC
This study is for people with advanced bowel cancer that has spread (metastatic) and is 'microsatellite stable' (MSS). It tests new drug combinations with standard treatment (FOLFOX and bevacizumab) to see if they are safe and work well as a first treatment option.
For: Metastatic Microsatellite-stable Colorectal CancerUnited States · Australia · Canada - RecruitingPHASE1
A Study to Evaluate INCB161734 in Participants With Advanced or Metastatic Solid Tumors With KRAS G12D Mutation
This study is looking at a new treatment called INCB161734 for advanced cancers with a specific genetic change (KRAS G12D mutation). Researchers want to see if it's safe and how well it works, either alone or with other cancer drugs.
For: Solid TumorsUnited States · Australia · Belgium