- RecruitingPHASE3
Study to Evaluate Safety, Tolerability and Efficacy of Inclisiran in Children With Homozygous Familial Hypercholesterolemia
This study is looking at a new medicine called inclisiran for children aged 2 to 11 with a severe type of high cholesterol called homozygous familial hypercholesterolemia (HoFH). The aim is to see if it's safe, well-tolerated, and helps lower their cholesterol levels.
For: Familial Hypercholesterolemia - HomozygousUnited States · Austria · China - RecruitingPHASE3
Study to Evaluate Efficacy and Safety of Inclisiran in Children With Heterozygous Familial Hypercholesterolemia
This study is testing a new medicine, inclisiran, for children aged 6-11 with a genetic condition called heterozygous familial hypercholesterolemia (HeFH). It aims to see how well inclisiran lowers 'bad' cholesterol and if it's safe for them.
For: Familial Hypercholesterolemia - HeterozygousUnited States · Argentina · Austria - RecruitingPHASE3
Lp(a) Lowering Study of Pelacarsen (TQJ230) With Background Inclisiran in Participants With Elevated Lp(a) and Established ASCVD
This study looks at a new medicine, pelacarsen, for people with heart and circulation problems and high levels of a specific fat called Lp(a). It aims to see if it's safe and effective when used alongside another medicine, inclisiran.
For: Atherosclerotic Cardiovascular Disease (ASCVD)United States · China · France - RecruitingNA
PET Imaging of Inflammation and Lipid Lowering Study
This study looks at new ways to scan and treat high cholesterol and hardened arteries. It uses special scans and medications like Inclisiran or Colchicine to see how they affect swelling in the arteries. We hope to find better ways to understand and treat these conditions.
For: Hypercholesterolemia · Hypercholesterolemia, Familial · AtherosclerosisUnited Kingdom - RecruitingPHASE3
Long-term Safety and Tolerability of Inclisiran in Participants With HeFH or HoFH Who Have Completed the Pediatric ORION-16, ORION-13, ORION-20, or ORION-19 Studies
This study looks at the long-term safety of a medicine called inclisiran for people aged 12-100 with high cholesterol due to a genetic condition (HeFH or HoFH). It's for those who have already been in earlier inclisiran studies.
For: Heterozygous or Homozygous Familial HypercholesterolemiaUnited States · Argentina · Brazil - Active not recruitingPHASE3
A Randomized Trial Assessing the Effects of Inclisiran on Clinical Outcomes Among People With Cardiovascular Disease
This study, ORION-4, will test if a new injection called inclisiran can safely lower the risk of heart attacks and strokes in people who have already had these conditions or related treatments. It's for people with heart and blood vessel problems.
For: Atherosclerotic Cardiovascular DiseaseUnited States · United Kingdom - Active not recruiting
Study Evaluating LDL-C Change and Adherence to Inclisiran Lipid-lowering Therapy in ASCVD
This study looks at how well a medicine called inclisiran works for people with high cholesterol and helps prevent heart problems. We want to see if it lowers bad cholesterol and if people stick to taking it as part of their usual care.
For: Primary Hypercholesterolemia · Mixed DyslipidemiaAustria · China · Israel