Laboratory Biomarker Analysis clinical trials
18 indexed studies · 2 currently recruiting
- Active not recruitingPHASE2
Trametinib With or Without GSK2141795 in Treating Patients With Metastatic Uveal Melanoma
This study looks at two medicines, trametinib alone or with GSK2141795, for uveal melanoma that has spread. It wants to see which treatment works best to slow down or stop the cancer's growth.
For: Recurrent Uveal Melanoma · Stage IV Uveal Melanoma AJCC v7United States · France · United Kingdom - Active not recruitingPHASE3
Hormone Therapy With or Without Combination Chemotherapy in Treating Women Who Have Undergone Surgery for Node-Negative Breast Cancer (The TAILORx Trial)
This study looks at the best treatment for women with a common type of early breast cancer. It compares hormone therapy alone against hormone therapy plus chemotherapy, using a special test to help decide which is best for each woman.
For: Breast Adenocarcinoma · Hormone Receptor Positive · Stage IA Breast Cancer AJCC v7United States · Australia · Canada - Active not recruitingPHASE3
Digital Tomosynthesis Mammography and Digital Mammography in Screening Patients for Breast Cancer
This study compares two types of X-rays for breast cancer screening: standard digital mammography and a 3D version called digital tomosynthesis. It aims to see if the 3D X-ray is better at finding cancer and reduces the need for more tests.
For: Breast ScreeningUnited States · Argentina · Canada - Active not recruitingPHASE2
Aspirin in Preventing Disease Recurrence in Patients With Barrett Esophagus After Successful Elimination by Radiofrequency Ablation
This study looks at whether a daily low-dose aspirin can stop Barrett's oesophagus from coming back after successful treatment. We're also checking how safe aspirin is and tracking specific body markers that might show if the condition is returning.
For: Barrett Esophagus · Esophageal AdenocarcinomaUnited States · Canada - Active not recruitingPHASE3
Phase III Trial of Anaplastic Glioma Without 1p/19q Loss of Heterozygosity (LOH)
This study looks at treating a type of brain tumour called anaplastic glioma. It compares standard radiation treatment with adding a drug called temozolomide. Researchers want to see if adding temozolomide during or after radiation helps people live longer and improves their quality of life.
For: Brain and Central Nervous System TumorsUnited States · Australia · Belgium - Active not recruitingPHASE3
Doxorubicin Hydrochloride and Cyclophosphamide Followed by Paclitaxel With or Without Carboplatin in Treating Patients With Triple-Negative Breast Cancer
This study looks at how well different combinations of chemotherapy drugs work for triple-negative breast cancer. Researchers want to know if adding a drug called carboplatin improves treatment outcomes when given alongside other standard chemotherapy drugs after surgery.
For: Breast Adenocarcinoma · Estrogen Receptor Negative · HER2/Neu NegativeUnited States · Canada - Active not recruitingPHASE2
Vismodegib in Treating Patients With Advanced Chondrosarcomas
This study looks at a drug called vismodegib for people with advanced chondrosarcoma, a type of bone cancer. It aims to see how well the drug stops the cancer from growing and spreading, especially when other treatments haven't worked or the cancer is hard to remove.
For: Clear Cell Chondrosarcoma · Dedifferentiated Chondrosarcoma · Locally Advanced ChondrosarcomaFrance - Active not recruitingPHASE3
Combination Chemotherapy With or Without Temsirolimus in Treating Patients With Intermediate Risk Rhabdomyosarcoma
This study looks at new ways to treat a type of cancer called rhabdomyosarcoma. It compares standard chemotherapy with chemotherapy plus a drug called temsirolimus, for patients whose cancer has an average chance of coming back. Researchers want to see if adding temsirolimus helps more.
For: Alveolar Rhabdomyosarcoma · Botryoid-Type Embryonal Rhabdomyosarcoma · Embryonal RhabdomyosarcomaUnited States · Australia · Canada - Active not recruitingPHASE3
Tretinoin and Arsenic Trioxide in Treating Patients With Untreated Acute Promyelocytic Leukemia
This study is for young people with a type of leukaemia called APL. It tests if a treatment combining two drugs, tretinoin and arsenic trioxide, can work as well as standard chemotherapy, but with fewer long-term side effects, especially for the heart.
For: Acute Promyelocytic Leukemia With t(15;17)(q24.1;q21.2); PML-RARAUnited States · Australia · Canada - Active not recruiting
Late Effects After Treatment in Patients With Previously Diagnosed High-Risk Neuroblastoma
This study looks at how neuroblastoma treatment affects children and young adults years later. We want to understand these long-term effects to help improve future treatments and quality of life for survivors.
For: Recurrent Neuroblastoma · Stage 2A Neuroblastoma · Stage 2B NeuroblastomaUnited States · Australia · Canada - Active not recruitingPHASE2
Radiation Therapy and Fluorouracil With or Without Combination Chemotherapy Followed by Surgery in Treating Patients With Stage II or Stage III Rectal Cancer
This study looks at different ways to combine radiation and chemotherapy before surgery for stage 2 or 3 bowel cancer. Doctors hope to shrink tumours, making surgery easier and more successful. It compares various treatment plans to see which works best.
For: Colorectal CancerUnited States · Canada - Active not recruitingPHASE2, PHASE3
Individualized Treatment Treating Patients With Stage II-IVB Nasopharyngeal Cancer Based on EBV DNA
This study looks at new ways to treat nasopharyngeal cancer, a type of head and neck cancer. It focuses on using a blood test for the Epstein-Barr virus (EBV) to decide the best treatment after initial therapy. We want to see if different drug combinations improve outcomes.
For: Epstein-Barr Virus Infection · Stage II Nasopharyngeal Carcinoma · Stage III Nasopharyngeal CarcinomaUnited States · Australia · Canada - Active not recruitingPHASE2
Imatinib Mesylate or Dasatinib in Treating Patients With Previously Untreated Chronic Phase Chronic Myelogenous Leukemia
This study looks at two medicines, imatinib and dasatinib, for people with a type of blood cancer called chronic myeloid leukaemia (CML) who haven't been treated before. It aims to see which medicine works best at different doses.
For: Chronic Myeloid Leukemia, BCR-ABL1 PositiveUnited States · Canada - Recruiting
Studying Health Outcomes After Treatment in Patients With Retinoblastoma
This study looks at the long-term health of children and young people who have had retinoblastoma, a type of eye cancer. By collecting information, samples, and doing eye tests, doctors hope to better understand the cancer, its treatments, and how it affects patients over time.
For: Retinoblastoma · Cancer Survivor · Biological SiblingUnited States · Canada - Active not recruitingPHASE3
Testing the Addition of a New Anti-Cancer Drug, Triapine, to the Usual Chemotherapy Treatment (Cisplatin) During Radiation Therapy for Advanced-stage Cervical and Vaginal Cancers
This study tests if a new drug, Triapine, added to usual chemotherapy and radiation, works better for advanced cervical or vaginal cancer than the usual treatment alone. It aims to see if this combination helps people live longer and stops cancer from coming back.
For: Advanced Vaginal Adenocarcinoma · Advanced Vaginal Adenosquamous Carcinoma · Advanced Vaginal Squamous Cell CarcinomaUnited States · Canada · Puerto Rico - RecruitingPHASE3
Observation or Radiation Therapy in Treating Patients With Newly Diagnosed Grade II Meningioma That Has Been Completely Removed by Surgery
This study compares watchful waiting with radiation therapy for people who have had a common type of brain tumour called grade 2 meningioma completely removed. It aims to see if radiation after surgery helps prevent the tumour from returning.
For: Grade 2 Meningioma · Intracranial MeningiomaUnited States · Canada · India - Active not recruitingPHASE3
Hypofractionated Radiation Therapy After Mastectomy in Preventing Recurrence in Patients With Stage IIa-IIIa Breast Cancer
This study compares two ways of giving radiation therapy after breast cancer surgery. It's for women with certain types of stage 2 or 3 breast cancer who have had a mastectomy. The aim is to see if a shorter, stronger radiation treatment is as good, or better, at stopping cancer from coming back.
For: Ductal Breast Carcinoma · Invasive Breast Carcinoma · Lobular Breast CarcinomaUnited States · Canada - Active not recruitingPHASE2
Azacitidine With or Without Lenalidomide or Vorinostat in Treating Patients With Higher-Risk Myelodysplastic Syndromes or Chronic Myelomonocytic Leukemia
This study looks at treating certain blood cancers with a drug called azacitidine. Researchers want to see if adding lenalidomide or vorinostat makes azacitidine work better. It’s for adults with higher-risk myelodysplastic syndromes (MDS) or chronic myelomonocytic leukemia (CMML).
For: Chronic Myelomonocytic Leukemia · Chronic Myelomonocytic Leukemia-1 · Chronic Myelomonocytic Leukemia-2United States · Canada