- RecruitingPHASE3
A Study to Evaluate Long-term Safety in Participants Who Have Participated in Other Luspatercept (ACE-536) Clinical Trials
This study looks at the long-term safety of a medicine called luspatercept for people with certain blood disorders. It's for those already taking part in a luspatercept study to see if continuing the treatment is safe over a longer period.
For: Myelodysplastic Syndromes (MDS) · Beta-thalassemia · Myeloproliferative Neoplasm(MPN)-Associated MyelofibrosisUnited States · Australia · Belgium - Active not recruitingPHASE3
A Study to Compare the Efficacy and Safety of Luspatercept (ACE-536) Versus Epoetin Alfa for the Treatment of Anemia Due to IPSS-R Very Low, Low, or Intermediate Risk Myelodysplastic Syndromes (MDS) Participants Who Require Red Blood Cell Transfusions and Are ESA Naïve
This study compares a new medicine, luspatercept, with a standard one, epoetin alfa, for people with a type of blood disorder called myelodysplastic syndromes (MDS). It aims to see if luspatercept can reduce the need for blood transfusions.
For: Myelodysplastic SyndromesUnited States · Australia · Austria - RecruitingPHASE2
Study of Momelotinib in Combination With Luspatercept in Participants With Transfusion Dependent Myelofibrosis
This study looks at a new combination treatment, momelotinib and luspatercept, for people with myelofibrosis who need regular blood transfusions. It hopes to see if this combination is safe and effective for patients, whether or not they've had previous myelofibrosis treatments.
For: Primary Myelofibrosis · Myelofibrosis; Primary Myelofibrosis; Post-polycythemia Vera Myelofibrosis; Post-essential Thrombocythemia MyelofibrosisUnited States · Canada · France - Active not recruitingPHASE3
A Study to Assess Luspatercept in Lower-risk Myelodysplastic Syndrome Participants
This study looks at a medicine called Luspatercept for people with a lower-risk type of Myelodysplastic Syndrome (MDS). We want to see if it's safe and helps reduce the need for blood transfusions.
For: Myelodysplastic SyndromesUnited States · Belgium · Czechia - RecruitingPHASE2
MYELOMATCH: A Screening Study to Assign People With Myeloid Cancer to a Treatment Study or Standard of Care Treatment Within myeloMATCH (MyeloMATCH Screening Trial)
This study helps doctors find the best treatments for people with certain blood cancers like leukaemia. It uses special tests on blood and bone marrow to match patients with personalised treatments or standard care, aiming to improve how cancer treatments are chosen.
For: Acute Myeloid Leukemia · Acute Myeloid Leukemia Arising From Previous Myelodysplastic/Myeloproliferative Neoplasm · Acute Myeloid Leukemia Post Cytotoxic TherapyUnited States · Canada · Puerto Rico - Active not recruitingPHASE3
ELEMENT-MDS: A Study to Compare the Efficacy and Safety of Luspatercept in Participants With Myelodysplastic Syndrome (MDS) and Anemia Not Receiving Blood Transfusions
This study looks at a new medicine called Luspatercept for adults with a certain type of blood disorder (MDS) who have anaemia but don't yet need blood transfusions. It compares Luspatercept to another common medicine, Epoetin Alfa, to see which is better and safer.
For: Myelodysplastic SyndromesUnited States · Argentina · Australia - Active not recruitingPHASE3
Assessment of Effectiveness and Safety of Luspatercept in Patients Suffering From Lower-risk Myelodysplastic Syndrome.
This study is looking at a new medicine called Luspatercept for people with a type of blood condition called Myelodysplastic Syndromes (MDS). It wants to see how well it works and if it's safe for patients who haven't responded to other treatments.
For: Myelodysplastic SyndromesAustria · Germany · Spain - RecruitingPHASE2
A Study to Determine the Efficacy and Safety of Luspatercept in Adult Participants and to Evaluate the Safety and Pharmacokinetics in and Adolescent Participants With Alpha (α)-Thalassemia
This study looks at a new medicine called luspatercept for people with a type of anaemia called alpha-thalassaemia. It aims to see if the medicine is safe and helps reduce the need for blood transfusions.
For: AnemiaCanada · China · Greece