Magnetic resonance imaging clinical trials
35 indexed studies · 20 currently recruiting
- CompletedNot Applicable
Spinal cord magnetic resonance imaging in multiple sclerosis
This study looks at how multiple sclerosis affects the spinal cord in its early stages. Researchers in Edinburgh are using advanced MRI scans to take detailed pictures of the spine. The aim is to help doctors better understand the disease, predict how it progresses, and develop better future treatments.
For: Establishing spinal cord imaging biomarkers in people with recently diagnosed multiple sclerosisUnited Kingdom · Scotland - RecruitingPHASE3
Active Surveillance, Bleomycin, Etoposide, Carboplatin or Cisplatin in Treating Pediatric and Adult Patients With Germ Cell Tumors
This study looks at how best to treat a type of cancer called germ cell tumours in children and adults. It compares simply watching the tumour after surgery with different chemotherapy treatments to see which works best and causes fewer side effects.
For: Childhood Extracranial Germ Cell Tumor · Extragonadal Embryonal Carcinoma · Germ Cell TumorUnited States · Australia · Canada - RecruitingPHASE2
A Study to Give Treatment Inside the Eye to Treat Retinoblastoma
This study looks at a new way to treat retinoblastoma, a type of eye cancer in children. It combines standard chemotherapy with a special injection of medicine called melphalan directly into the eye. The goal is to see if this new treatment is safe and more effective, especially for tougher cases.
For: Bilateral Retinoblastoma · Childhood Intraocular Retinoblastoma · Group D RetinoblastomaUnited States · Australia · Canada - RecruitingPHASE2
Xenon-129 and Inert Fluorinated Gas Lung MRI: Study of Healthy Volunteers and Participants With Pulmonary Disease
This study uses special MRI scans with safe gases to look at lungs in people with cystic fibrosis and asthma, and healthy volunteers. The aim is to see how well these new scanning methods work and what they can tell us about lung health.
For: Cystic Fibrosis · AsthmaCanada - RecruitingPHASE2
A Study Using Nivolumab, in Combination With Chemotherapy Drugs to Treat Nasopharyngeal Carcinoma (NPC)
This study looks at combining nivolumab, an immunotherapy drug, with chemotherapy and then radiation for young people with nasopharyngeal cancer. Researchers want to see if this new treatment can fight the cancer effectively, understand its side effects, and potentially reduce radiation for children.
For: Stage II Nasopharyngeal Carcinoma AJCC v8 · Stage III Nasopharyngeal Carcinoma AJCC v8 · Stage IV Nasopharyngeal Carcinoma AJCC v8United States · Canada · New Zealand - Active not recruitingPHASE2
Testing Ipilimumab and Nivolumab Combination With or Without Cabozantinib in People >= 18 Years Old With Advanced Soft Tissue Sarcoma
This study looks at treating advanced soft tissue sarcoma with a combination of two immunotherapy drugs (ipilimumab and nivolumab), alone or with an additional drug called cabozantinib, to see which works best.
For: Locally Advanced Extraskeletal Myxoid Chondrosarcoma · Locally Advanced Leiomyosarcoma · Locally Advanced LiposarcomaUnited States · Canada - Active not recruitingPHASE3
Immunotherapy (Nivolumab or Brentuximab Vedotin) Plus Combination Chemotherapy in Treating Patients With Newly Diagnosed Stage III-IV Classic Hodgkin Lymphoma
This study compares two immunotherapy drugs (nivolumab or brentuximab vedotin) when used with chemotherapy for newly diagnosed, advanced Hodgkin lymphoma. It aims to see which combination works best at shrinking the cancer and keeping it away.
For: Ann Arbor Stage III Hodgkin Lymphoma · Ann Arbor Stage III Lymphocyte-Depleted Classic Hodgkin Lymphoma · Ann Arbor Stage III Mixed Cellularity Classic Hodgkin LymphomaUnited States · Canada · Puerto Rico - RecruitingPHASE2
Testing the Addition of BMS-986016 (Relatlimab) to the Usual Immunotherapy After Initial Treatment for Recurrent or Metastatic Nasopharyngeal Cancer
This study looks at adding a new drug, relatlimab, to current treatments for nasopharyngeal cancer that has come back or spread. The aim is to see if this addition can help keep the cancer from growing or spreading for longer.
For: Metastatic Nasopharyngeal Carcinoma · Recurrent Nasopharyngeal Carcinoma · Stage IV Nasopharyngeal Carcinoma AJCC v8United States · Australia · Canada - Recruiting
Contribution of Computed Tomography and Cardiac-MRI in Atrial Fibrillation Ablation
This study looks at whether special scans (CT and MRI) can help doctors better understand who might benefit most from a common heart procedure called AF ablation. It aims to see if fat in the heart or how the heart muscle moves can predict how well the treatment works.
For: Atrial FibrillationFrance - RecruitingPHASE1
Testing the Addition of Sunitinib Malate to Lutetium Lu 177 Dotatate (Lutathera) in Pancreatic Neuroendocrine Tumors
This study is testing a new combination of treatments for advanced pancreatic neuroendocrine tumours. We want to see if adding sunitinib malate to lutetium Lu 177 dotatate is safe and effective. This research aims to find better ways to fight these specific cancers.
For: Metastatic Pancreatic Neuroendocrine Tumor · Pancreatic Neoplasm · Stage III Pancreatic Neuroendocrine Tumor AJCC v8United States · Canada - RecruitingPHASE3
Testing Shorter Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients With High Risk Prostate Cancer
This study compares two ways to give radiation therapy for high-risk prostate cancer. One uses fewer, stronger treatments (SBRT), and the other is the usual longer course. We want to see if the shorter treatment works just as well to stop the cancer from coming back.
For: Prostate Adenocarcinoma · Stage III Prostate Cancer AJCC v8 · Stage IVA Prostate Cancer AJCC v8United States · Canada · Hong Kong - Recruiting
Magic Angle Direction Imaging (MADI) ACL Study
This study is testing a new type of MRI scanner that could give doctors more detailed pictures of injured ligaments and tendons, like those in the knee. It aims to improve how we diagnose and understand injuries such as ACL tears, potentially leading to better care.
For: Anterior Cruciate Ligament Injuries · Meniscus TearUnited Kingdom - Active not recruitingPHASE2
Testing the Addition of the Drug Relugolix to the Usual Radiation Therapy for Advanced-Stage Prostate Cancer, The NRG Promethean Study
This study looks at combining a drug called relugolix with usual radiation therapy for advanced prostate cancer that has spread to limited other areas. It aims to see if this combination helps stop the cancer from spreading further compared to radiation alone.
For: Oligometastatic Prostate Carcinoma · Prostate Adenocarcinoma · Prostate Ductal AdenocarcinomaUnited States · Canada - RecruitingNA
Montpellier PROspective Cohort in Relapsing Remitting Multiple Sclerosis Using Imaging and Serologic
This study looks at people in France with Relapsing Remitting Multiple Sclerosis (RRMS) to compare how two types of MS treatments (standard vs. high-strength) affect brain shrinkage over three years, using MRI scans and other tests.
For: Multiple SclerosisFrance - Active not recruitingPHASE2
Cabozantinib S-malate and Nivolumab in Treating Patients With Advanced, Recurrent, or Metastatic Endometrial Cancer
This study looks at new treatments for advanced endometrial cancer that has come back or spread. It tests if combining two drugs, cabozantinib and nivolumab, works better than nivolumab alone to shrink cancer and help people live longer. This could offer new hope for patients.
For: Advanced Endometrial Carcinoma · Metastatic Endometrial Carcinoma · Recurrent Endometrial CarcinomaUnited States · Canada - RecruitingPHASE3
Testing a Standardized Approach to Surgery and Chemotherapy for Type I Pleuropulmonary Blastoma or the Addition of an Anti-cancer Drug, Topotecan, to the Usual Treatment for Types II and III Pleuropulmonary Blastoma
This study looks at the best way to treat a rare childhood lung cancer called Pleuropulmonary Blastoma (PPB). For Type I PPB, it compares surgery alone to surgery with chemotherapy. For Types II and III PPB, it adds a new drug, Topotecan, to standard treatment.
For: Pleuropulmonary BlastomaUnited States · Canada - RecruitingPHASE2
A Study of Lower Radiotherapy Dose to Treat Children With CNS Germinoma
This study looks at treating children and young adults with a type of brain tumour called germinoma. Researchers want to see if using a lower dose of radiation therapy after chemotherapy can work just as well, but with fewer long-term side effects.
For: Basal Ganglia Germinoma · Diabetes Insipidus · GerminomaUnited States · Australia · Canada - Active not recruitingPHASE3
A Study to Compare Early Use of Vinorelbine and Maintenance Therapy for Patients With High Risk Rhabdomyosarcoma
This study looks at new ways to treat a type of cancer called rhabdomyosarcoma, which can be aggressive. We're testing if adding a drug called vinorelbine to standard treatment, and then using a 'maintenance' therapy, helps stop the cancer from coming back.
For: Alveolar Rhabdomyosarcoma · Botryoid-Type Embryonal Rhabdomyosarcoma · Embryonal RhabdomyosarcomaUnited States · Australia · Canada - Active not recruitingPHASE2
Treatment With Dinutuximab, Sargramostim (GM-CSF), and Isotretinoin in Combination With Irinotecan and Temozolomide After Intensive Therapy for People With High-Risk Neuroblastoma (NBL)
This study looks at combining existing treatments for high-risk neuroblastoma to see if it works better. It's for children and young people who have already had intensive therapy, to help prevent the cancer from coming back.
For: Ganglioneuroblastoma, Nodular · NeuroblastomaUnited States · Australia · Canada - Active not recruitingPHASE2
Gemcitabine Hydrochloride and Cisplatin With or Without Veliparib or Veliparib Alone in Treating Patients With Locally Advanced or Metastatic Pancreatic Cancer
This study looks at new ways to treat pancreatic cancer that has spread. It compares standard chemotherapy with or without a new drug called veliparib. We're testing if adding veliparib helps stop cancer growth, especially in people with specific genetic changes.
For: Locally Advanced Pancreatic Adenocarcinoma · Metastatic Pancreatic Adenocarcinoma · Stage III Pancreatic Cancer AJCC v8United States · Canada · Israel - Active not recruitingPHASE1, PHASE2
Testing the Addition of Tazemetostat to the Immunotherapy Drug, Pembrolizumab (MK-3475), in Advanced Urothelial Carcinoma
This study is looking into a new treatment for advanced bladder cancer. It combines two drugs, tazemetostat and pembrolizumab, to see if they work better together. Doctors want to find the safest dose and understand how well this combination fights the cancer.
For: Locally Advanced Urothelial Carcinoma · Metastatic Urothelial Carcinoma · Stage III Bladder Cancer AJCC v8United States · Canada - Active not recruitingPHASE3
A Study of the Drugs Selumetinib Versus Carboplatin/Vincristine in Patients With Neurofibromatosis and Low-Grade Glioma
This study compares a new drug, selumetinib, with a standard treatment (carboplatin/vincristine) for children and young people aged 2-21 with a type of brain tumour called low-grade glioma, linked to Neurofibromatosis Type 1. It aims to see if the new drug is as effective and especially if it improves vision.
For: Low Grade Glioma · Neurofibromatosis Type 1 · Visual Pathway GliomaUnited States · Canada · Puerto Rico - Active not recruiting
MRI and Stable Isotope Tracer Studies for Detecting the Progression of Non-Alcoholic Steatohepatitis (NASH)
This study looks at how non-alcoholic fatty liver disease (NAFLD) gets worse. We use special scans and tests to understand changes in the body and how a substance called L-carnitine might help. This could lead to better ways to find and treat liver problems early.
For: Non-Alcoholic Fatty Liver DiseaseUnited Kingdom - RecruitingPHASE3
Observation or Radiation Therapy in Treating Patients With Newly Diagnosed Grade II Meningioma That Has Been Completely Removed by Surgery
This study compares watchful waiting with radiation therapy for people who have had a common type of brain tumour called grade 2 meningioma completely removed. It aims to see if radiation after surgery helps prevent the tumour from returning.
For: Grade 2 Meningioma · Intracranial MeningiomaUnited States · Canada · India - Active not recruitingPHASE3
Comparing Radiation Therapy to Usual Treatment for Patients With High-Risk Bone Metastases That Are Not Causing Pain, PREEMPT Trial
This study compares adding radiation to usual care for cancer patients with high-risk bone growths that aren't painful. It aims to see if this helps prevent problems like bone breaks better than usual care alone.
For: Metastatic Malignant Neoplasm in the Bone · Metastatic Malignant Solid NeoplasmUnited States · Canada - RecruitingPHASE2
Using Nivolumab Alone or With Cabozantinib to Prevent Mucosal Melanoma Return After Surgery
This study looks at new ways to treat a rare type of skin cancer called mucosal melanoma, found inside the body. It tests if a drug called nivolumab, alone or with another drug called cabozantinib, can stop the cancer from coming back after surgery or help those where surgery wasn't enough.
For: Anal Melanoma · Bladder Melanoma · Cervical MelanomaUnited States · Canada - Recruiting
Microvascular Cardiac Allograft Vasculopathy Trial
This study aims to understand why some people who have had a heart transplant develop problems with the tiny blood vessels in their new heart. We're looking at genes, how the heart looks and works, and other factors to find out more.
For: Cardiac Allograft VasculopathyGermany - Active not recruitingPHASE2
Testing the Combination of Two Anticancer Drugs M1774 (Tuvusertib) and Avelumab to Evaluate Their Safety and Effectiveness in Treating Merkel Cell Skin Cancer, MATRiX Trial
This study looks at combining two cancer drugs, tuvusertib and avelumab, for people with advanced Merkel cell skin cancer that hasn't responded to previous treatment. It aims to see if the combination works better than tuvusertib alone to stop the cancer from getting worse.
For: Clinical Stage III Cutaneous Merkel Cell Carcinoma AJCC v8 · Clinical Stage IV Cutaneous Merkel Cell Carcinoma AJCC v8 · Locally Advanced Merkel Cell CarcinomaUnited States · Canada - Active not recruiting
Observing Young Patients With Ependymoma Undergoing Standard Combination Chemotherapy
This study looks at how young children with a type of brain tumour called ependymoma respond to standard chemotherapy. It also checks for long-term side effects to help doctors improve treatment for them in the future.
For: Brain and Central Nervous System Tumors · Cognitive/Functional Effects · Long-term Effects Secondary to Cancer Therapy in ChildrenUnited Kingdom - Not yet recruiting
IBM Dietary Surveillance Study
This study looks at how diet might affect people with Inclusion Body Myositis (IBM). Researchers want to see if food choices can influence muscle health and daily abilities in those with IBM, comparing them to healthy adults.
For: Inclusion Body MyositisUnited Kingdom - Enrolling by invitation
Twins MR Imaging Study
This study uses MRI scans to look at how different body parts age in twins. By comparing twins, researchers hope to learn more about how genes, lifestyle, and environment affect ageing and diseases like Alzheimer's and heart problems.
For: AgingUnited Kingdom - Active not recruiting
Glymphatic MRI in Clinically Isolated Syndrome
This study looks at a new way to scan the brain to understand how a vital cleaning system, the glymphatic system, works in people with Clinically Isolated Syndrome (CIS), which often leads to Multiple Sclerosis. The aim is to see if problems with this system contribute to the development of MS.
For: Clinically Isolated SyndromeUnited Kingdom - RecruitingNA
Early Psychosis: Investigating Cognition
This study explores brain chemistry changes in people who have recently experienced psychosis. It investigates how brain chemicals like glutamate might affect memory and attention, and if a mild electrical brain stimulation could offer a new, personalised treatment approach.
For: First Episode Psychosis (FEP) · PsychosisUnited Kingdom - Recruiting
Capturing MultiORgan Effects of COVID-19
This study, called C-MORE, looks at how COVID-19 affects different parts of the body in people who've left hospital. It uses MRI scans to check organs like the lungs and heart, and also looks at quality of life and mental health.
For: Coronavirus Infection · Multi-Organ DisorderUnited Kingdom - Not yet recruitingNA
Closed-loop tES-non-invasive Stimulation
This study looks at new ways to boost brain power in healthy adults (18-40) using gentle brain stimulation. We're checking if a smarter, 'closed-loop' method works better than standard approaches to improve thinking skills.
For: Closed-loop Brain StimulationUnited Kingdom