- RecruitingPHASE3
ROSETTA Breast-01: The Effects and Safety of Pumitamig in Patients With Triple-Negative Breast Cancer
This study is looking into a new drug called Pumitamig for people with a type of breast cancer called triple-negative breast cancer. It compares Pumitamig plus standard chemotherapy with a dummy drug (placebo) plus chemotherapy to see if it's safe and effective.
For: Breast NeoplasmsUnited States · Australia · Belgium - RecruitingPHASE3
Regeneration in Cervical Degenerative Myelopathy
This study investigates if a drug called Ibudilast can improve symptoms like hand problems, balance, and pain after surgery for a neck condition called Degenerative Cervical Myelopathy (DCM), which causes spinal cord compression.
For: Myelopathy · Spinal Cord DiseasesUnited Kingdom - Active not recruitingPHASE3
A Phase III Study to Investigate Efficacy, Safety and Tolerability of Iptacopan Compared With Placebo in Participants Aged 18 to 85 Years With gMG.
This study is testing a new medicine called iptacopan for people aged 18-85 with a type of muscle weakness called generalized Myasthenia Gravis (gMG). It's compared to a dummy medicine to see if it's safe and helps improve symptoms while continuing usual care.
For: Generalized Myasthenia GravisUnited States · Argentina · Australia - Active not recruitingPHASE3
Study of Vorasidenib (AG-881) in Participants With Residual or Recurrent Grade 2 Glioma With an IDH1 or IDH2 Mutation (INDIGO)
This study is for people with a specific type of brain tumour called Grade 2 glioma, which has come back or wasn't fully removed by surgery. It's testing a new drug called vorasidenib against a dummy pill to see if it can help stop the tumour from growing.
For: Grade 2 Glioma · Residual Glioma · Recurrent GliomaUnited States · Canada · France - Active not recruitingPHASE3
A Phase 3 Study of Barzolvolimab in Participants With Chronic Spontaneous Urticaria (CSU)
This study is testing a new medicine, barzolvolimab, for people with chronic spontaneous urticaria (CSU), also known as chronic hives. It aims to see if the medicine is safe and helps reduce hives better than a dummy medicine (placebo) for those whose current treatments aren't enough.
For: Chronic Spontaneous UrticariaUnited States · Australia · Bulgaria - RecruitingPHASE3
Randomized Study in Children and Adolescents With Migraine: Acute Treatment
This study is testing a new medication (rimegepant) for children and teenagers aged 6 to 17 who experience migraines. Researchers want to see if it's safe and effective compared to a dummy pill to relieve moderate to severe migraine attacks.
For: Pediatric MigraineUnited States · Canada · China - Active not recruitingPHASE3
A Phase 3 Study of Barzolvolimab in Participants With Chronic Spontaneous Urticaria
This study looks at a new medicine called barzolvolimab for chronic hives that don't respond well to usual treatments. It will check if the medicine works, if it's safe, and how well people tolerate it compared to a dummy medicine.
For: Chronic Spontaneous UrticariaUnited States · Argentina · Belgium - RecruitingPHASE3
STOP-PKD: SGLT2-inhibition to Improve Prognosis in Polycystic Kidney Disease
This study is testing if a drug called dapagliflozin can help slow down kidney damage in people with a genetic kidney condition called Polycystic Kidney Disease (ADPKD). It compares the drug to a dummy pill (placebo) to see if it improves kidney function.
For: Polycystic Kidney, Autosomal DominantAustria · Germany · Netherlands - RecruitingPHASE3
Nicotinamide in Glaucoma (NAMinG): A Randomised, Placebo-controlled, Multi-centre, Phase III Trial
This study looks at whether a form of Vitamin B3, Nicotinamide (NAM), can help slow down sight loss in people recently diagnosed with open-angle glaucoma. It aims to see if NAM, when used with standard treatments, can protect vision.
For: Glaucoma, Open-AngleUnited Kingdom - RecruitingPHASE3
A Study to Investigate Efficacy, Safety and Tolerability of Barzolvolimab Versus Placebo in Adults With Cold Induced Urticaria and Symptomatic Dermographism Inadequately Controlled by H1-antihistamines (EMBARQ - ColdU and SD)
This study looks at a new drug, barzolvolimab, for people with cold urticaria or symptomatic dermographism – skin conditions causing hives or itching from cold or scratching. It checks if the drug is safe and helps when usual antihistamines don't work.
For: Chronic Inducible Urticaria · Cold Urticaria · Cold-Induced UrticariaUnited States · Germany · Lithuania - RecruitingPHASE2
A Multicenter Trial Assessing the Impact of Lipoprotein(a) Lowering With Pelacarsen (TQJ230) on the Progression of Calcific Aortic Valve Stenosis
This study is looking into a new medicine called Pelacarsen (TQJ230) for a heart condition called aortic stenosis. We want to see if this medicine can slow down the stiffening and narrowing of the heart's aortic valve. Participants will get either the study medicine or a dummy pill (placebo).
For: Aortic StenosisUnited States · Austria · Belgium