- CompletedPhase IV
A trial looking at metformin for early prostate cancer patients undergoing surgery
This UK clinical trial is testing whether metformin, a common diabetes medicine, can help treat prostate cancer. Men waiting for surgery to remove their prostate take either metformin or dummy tablets for several weeks before their operation. Researchers then study the removed tissue to see how the drug affects cancer cells.
For: Prostate cancerUnited Kingdom · England · Wales - Active not recruitingPHASE2
An Efficacy and Safety Study of Erdafitinib (JNJ-42756493) in Participants With Urothelial Cancer
This study looks at a new drug, erdafitinib, for people with a type of bladder cancer called urothelial cancer that has spread or can't be removed by surgery. It aims to see how well it works and if it's safe, specifically for those with certain genetic changes in their cancer.
For: Urothelial CancerUnited States · Austria · Belgium - RecruitingPHASE1, PHASE2
A Study Evaluating the Efficacy and Safety of Multiple Treatment Combinations in Patients With Metastatic or Locally Advanced Breast Cancer
This study looks at different treatment combinations for advanced breast cancer, including those that have spread or are hard to remove. Doctors want to see how well these new drug combinations work and if they are safe for patients.
For: Metastatic Breast CancerUnited States · Australia · France - RecruitingPhase II
A clinical trial investigating the use of a drug called metformin as a way of reducing the cancer risk in people with Li Fraumeni Syndrome (LFS)
This UK clinical trial is testing whether metformin, a common and safe diabetes medicine, can reduce the risk of cancer in people with Li Fraumeni Syndrome (LFS). Participants will either take daily metformin or receive standard monitoring. Everyone in the study receives yearly whole-body MRI scans and regular health check-ups.
For: Li Fraumeni SyndromeUnited Kingdom · England · Scotland - RecruitingPhase III
A study looking at whether metformin (a diabetes drug) can prevent weight gain caused by antipsychotics in people experiencing their first episode of psychosis
This study looks at whether a common diabetes medicine called metformin can stop people from gaining weight when they start taking treatments for their first episode of psychosis. We want to see if metformin can help manage weight often caused by these important medicines.
For: Antipsychotic induced weight gain in first episode psychosisUnited Kingdom · England - RecruitingTherapeutic use (Phase IV)
Transfer of metformin into human breast milk and the plasma of breastfeeding children - A low intervention trial with biobanking of breast milk and plasma in Västra Götalandsregionen and Region Örebro
This study looks at how much metformin, a diabetes medicine, passes into breast milk and then into a baby's blood. It's for breastfeeding mothers with type 2 or gestational diabetes who take metformin, to see if the medicine affects their baby.
For: type 2 diabetes mellitus and gestational diabetes mellitusSweden - RecruitingPhase II
Testing whether a commonly used drug to treat Diabetes can reduce injury to the lung following heart surgery and in critical illness.
Researchers are testing if a common diabetes drug, metformin, can help protect lungs during heart surgery. They want to see if it reduces lung damage and inflammation in patients having bypass surgery to, hopefully, learn more about treating a serious lung condition called ARDS.
For: Acute Respiratory Distress Syndrome, post-operative coronary artery bypass graft patientsUnited Kingdom - RecruitingPHASE4
Metformin for Antipsychotic-induced Weight Gain in Adults With Intellectual Disability
This study looks at whether a medicine called metformin can help adults with learning disabilities who've gained weight from antipsychotic medicines. These medicines are important, but weight gain can lead to other health problems.
For: Intellectual Disability · Developmental Disability · ObesityCanada - Active not recruitingPHASE2, PHASE3
Systemic Therapy in Advancing or Metastatic Prostate Cancer: Evaluation of Drug Efficacy
This study, called STAMPEDE, looks for better ways to treat prostate cancer that is spreading or has a high chance of spreading. It tests new treatments against standard ones to help men live longer and have a better quality of life.
For: Prostate CancerSwitzerland · United Kingdom - Active not recruitingPHASE2
Metformin, Neo-adjuvant Temozolomide and Hypo- Accelerated Radiotherapy Followed by Adjuvant TMZ in Patients With GBM
This study is looking at adding an existing diabetes drug, Metformin, to the usual treatment for a type of aggressive brain cancer called Glioblastoma (GBM). Researchers hope Metformin will make the standard treatments work better and help people live longer.
For: Glioblastoma MultiformeCanada - Recruiting
Pharmacokinetics and Safety of Commonly Used Drugs in Lactating Women and Breastfed Infants
This study looks at how medicines mothers take get into breast milk and affect their babies. We need breastfeeding mums taking common drugs to help us learn more about drug levels in milk and babies, to ensure safer choices for mums and their infants.
For: Lactating Women on Select DOI · Breastfed Infants of Mothers on Select DOIUnited States · Canada - Active not recruitingPHASE4
Ursodeoxycholic Acid vs Metformin in Gestational Diabetes Mellitus
This study compares two medicines, Ursodeoxycholic Acid and Metformin, for treating diabetes that starts during pregnancy (gestational diabetes). We want to see which one works better at controlling blood sugar in women who are overweight or obese and need medicine for their diabetes.
For: Gestational DiabetesUnited Kingdom - Active not recruitingPHASE1
To Evaluate the Safety, Tolerability, and Pharmacokinetics of Inavolisib Single Agent in Participants With Solid Tumors and in Combination With Endocrine and Targeted Therapies in Participants With Breast Cancer
This study looks at a new drug, Inavolisib, for people with solid tumours or breast cancer, focusing on safety and how the body handles it. It's an early-stage study, checking if the drug works alone or with other common cancer treatments.
For: Breast Cancer · Solid TumorUnited States · Canada · France