Methylprednisolone clinical trials
14 indexed studies · 6 currently recruiting
- Active not recruitingPHASE3
A Study to Evaluate the Efficacy and Safety of Obinutuzumab in Participants With ISN/RPS 2003 Class III or IV Lupus Nephritis
This study is looking at a new medicine called obinutuzumab for people with a serious kidney problem called lupus nephritis. Researchers want to see if it's safe and helps better than a dummy medicine when added to usual treatments, like steroids.
For: Lupus NephritisUnited States · Argentina · Brazil - Active not recruitingPHASE3
A Study to Evaluate the Efficacy, Safety and Pharmacokinetics (PK) of a Higher Dose of Ocrelizumab in Adults With Primary Progressive Multiple Sclerosis (PPMS)
This study looks at a new, higher dose of ocrelizumab for people with primary progressive multiple sclerosis (PPMS). Researchers want to see if this dose is safe and works better than the current approved dose to slow down the disease.
For: Multiple SclerosisUnited States · Argentina · Belgium - RecruitingPHASE2
A Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of Obinutuzumab in Adolescents With Active Class III or IV Lupus Nephritis and the Safety and PK of Obinutuzumab in Pediatric Participants
This study is looking at a new medicine called obinutuzumab for teenagers and children aged 5 to 17 with a kidney condition called lupus nephritis. We want to see if it's safe, how well it works, and how the body uses it.
For: Lupus NephritisUnited States · Brazil · Canada - RecruitingPHASE2, PHASE3
A Study to Investigate the Efficacy and Safety of Frexalimab Versus Tacrolimus in Adults Undergoing Kidney Transplantation
This study is looking at a new medicine called frexalimab for adults having a kidney transplant. It compares frexalimab to a standard medicine, tacrolimus, to see if it's safe and works well to prevent the body rejecting the new kidney.
For: Kidney Transplant RejectionUnited States · Argentina · Australia - RecruitingPHASE3
TACKLE-IT Trial - Treat Acute T Cell Rejection With Evidence and Confidence in Kidney Transplant Recipients
This study, TACKLE-IT, looks for the best steroid dose to treat 'rejection' in people who've had a kidney or kidney-pancreas transplant. Rejection happens when the body tries to get rid of the new organ. Too many steroids can cause problems, so finding the right amount is important.
For: Rejection; Transplant, Kidney · Rejection; Transplant, PancreasAustralia · Canada · New Zealand - Active not recruitingPHASE1, PHASE2
Phase 1/2 Clinical Trial of PR001 in Infants With Type 2 Gaucher Disease (PROVIDE)
This study is testing a new treatment, LY3884961, for babies with a serious inherited condition called Type 2 Gaucher disease. Researchers want to see if it's safe and effective. It's a long-term study, following babies for up to 5 years.
For: Gaucher Disease, Type 2United States · United Kingdom - RecruitingPHASE3
Efficacy and Safety of Infliximab for Immune Checkpoint Inhibitor Induced Colitis
This study looks at a new way to treat bowel inflammation (colitis) caused by cancer medicines called immune checkpoint inhibitors. It compares standard steroids with steroids plus a drug called infliximab to see which works best and fastest.
For: ColitisDenmark · United Kingdom - Active not recruitingPHASE3
A Study to Evaluate the Efficacy and Safety of Obinutuzumab in Participants With Systemic Lupus Erythematosus
This study is looking into a new treatment called Obinutuzumab for a condition called lupus (Systemic Lupus Erythematosus). It compares this new treatment with a dummy treatment (placebo) to see if it's safe and effective for people already getting standard lupus care.
For: Systemic Lupus ErythematosusUnited States · Argentina · Brazil - Active not recruitingPHASE3
A Study Evaluating the Efficacy and Safety of Obinutuzumab in Participants With Primary Membranous Nephropathy
This study is looking at a new treatment called Obinutuzumab for a kidney condition called primary membranous nephropathy (pMN). It's a Phase 3 study, meaning it's well into testing, to see if this new medicine works better and is safer than current treatments.
For: Primary Membranous NephropathyUnited States · Argentina · Brazil - Active not recruitingPHASE1, PHASE2
Phase 1/2 Clinical Trial of LY3884963 in Patients With Frontotemporal Dementia With Progranulin Mutations (FTD-GRN)
This study is testing a new medicine, LY3884963, for Frontotemporal Dementia (FTD) caused by a specific gene change. It will check if the medicine is safe, how it affects a protein called progranulin, and if it helps patients.
For: Frontotemporal DementiaUnited States · Australia · Belgium - Active not recruitingPHASE3
SC Versus IV Isatuximab in Combination With Pomalidomide and Dexamethasone in RRMM
This study is looking at a new way to give a medicine called isatuximab for a type of blood cancer called multiple myeloma. It compares giving the medicine as a shot under the skin versus through a drip into a vein, always with other standard treatments.
For: Plasma Cell Myeloma RecurrentUnited States · Argentina · Australia - RecruitingPHASE3
High Dose Steroids in Children With Stroke
This study looks at whether strong anti-inflammatory medicines (steroids) can help children recover from a type of stroke called focal cerebral arteriopathy (FCA). Scientists want to see if steroids, given alongside standard care, lead to better and faster recovery.
For: Paediatric StrokeAustralia · Austria · Denmark - Active not recruitingPHASE3
A Study to Evaluate the Efficacy, Safety and Pharmacokinetics (PK) of a Higher Dose of Ocrelizumab in Adults With Relapsing Multiple Sclerosis (RMS)
This study is testing a higher dose of a medicine called ocrelizumab for adults with a type of multiple sclerosis (MS) called relapsing MS. It compares the new dose to the standard dose to see if it's more effective and safe.
For: Multiple SclerosisUnited States · Argentina · Australia - RecruitingPHASE3
A Study to Evaluate Zilovertamab Vedotin (MK-2140) Combination With Rituximab Plus Cyclophosphamide, Doxorubicin, and Prednisone (R-CHP) Versus Rituximab Plus Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone (R-CHOP) in Participants With Previously Untreated DLBCL (MK-2140-010)
This study looks at a new drug, zilovertamab vedotin, combined with standard treatment for a type of blood cancer called diffuse large B-cell lymphoma (DLBCL). Researchers want to see if this new combination helps people live longer without their cancer growing or spreading, compared to standard treatment alone.
For: Diffuse Large B-Cell LymphomaUnited States · Argentina · Australia