- Active not recruitingPHASE1
A Study Evaluating Safety and Tolerability, and Pharmacokinetics of Navitoclax Monotherapy and in Combination With Ruxolitinib in Participants With Myeloproliferative Neoplasm
This study looks at a new drug, navitoclax, alone or with an existing drug, ruxolitinib, for a group of blood cancers called myeloproliferative neoplasms. Researchers want to see if it's safe, how the body handles it, and if it affects other drugs.
For: Myeloproliferative NeoplasmUnited States · Belgium · Bulgaria - Active not recruitingPHASE3
Study of Oral Navitoclax Tablet in Combination With Oral Ruxolitinib Tablet Versus Best Available Therapy to Assess Change in Spleen Volume in Adult Participants With Relapsed/Refractory Myelofibrosis
This study looks at a new drug, navitoclax, combined with ruxolitinib, or navitoclax alone, for adults with myelofibrosis whose previous treatment didn't work. It compares these to standard care to see how they affect spleen size and safety.
For: Myelofibrosis (MF)United States · Australia · Austria