- RecruitingPHASE3
A Master Protocol to Investigate Efficacy and Safety of Elecoglipron in Participants With Obesity or Overweight With or Without T2DM
This study is looking into a new medication called Elecoglipron for weight management. It's for adults who are overweight or have obesity, with or without Type 2 diabetes, to see if it helps them lose weight safely when combined with diet and exercise.
For: Weight ManagementUnited States · Argentina · Australia - Active not recruitingPHASE2, PHASE3
A Study of Guselkumab in Participants With Moderately to Severely Active Ulcerative Colitis
This study is looking at a new medicine called guselkumab for people with ulcerative colitis that isn't well-controlled. We want to see if it helps reduce symptoms and if it's safe to use for those with moderate to severe forms of the condition.
For: Ulcerative ColitisUnited States · Argentina · Australia - Active not recruitingPHASE1
A Phase 1b Study to Investigate Safety and Tolerability of ARGX-119 in Adult Participants With DOK7-Congenital Myasthenic Syndromes (CMS)
This study is testing a new medicine, ARGX-119, for adults with a specific type of muscle weakness called DOK7-Congenital Myasthenic Syndrome (CMS). It's looking at how safe the medicine is, if it causes side effects, and if it helps people feel better.
For: Congenital Myasthenic Syndrome · CMSUnited States · Canada · France - Active not recruitingPHASE3
A Phase 3 Study to Assess Efficacy and Safety of Tafasitamab Plus Lenalidomide and Rituximab Compared to Placebo Plus Lenalidomide and Rituximab in Patients With Relapsed/Refractory (R/R) Follicular Lymphoma or Marginal Zone Lymphoma.
This study looks at a new drug, tafasitamab, alongside standard treatments for follicular lymphoma and marginal zone lymphoma that have come back or not responded well. It aims to see if adding this new drug works better than the usual treatment alone.
For: Follicular Lymphoma · Marginal Zone LymphomaUnited States · Australia · Austria - RecruitingPHASE3
Efficacy, Safety and Tolerability of Givinostat in Non-ambulant Patients With Duchenne Muscular Dystrophy
This study is testing a new medicine, Givinostat, for boys aged 9-17 with Duchenne muscular dystrophy who use a wheelchair. Researchers want to see if it helps reduce muscle decline and is safe to use. Half the boys will get the medicine, and half a dummy pill for 18 months.
For: Duchenne Muscular DystrophyBelgium · Canada · Czechia - RecruitingPHASE2
Study to Explore the Therapeutic Effect of Eluxadoline in Treating Irritable Bowel Syndrome With Diarrhea in Children
This study is looking at a medicine called eluxadoline to see if it can help children aged 6-17 with Irritable Bowel Syndrome (IBS) that causes diarrhoea. Researchers want to understand how it works in children, if it's safe, and how well it helps manage symptoms.
For: Irritable Bowel SyndromeUnited States · Bulgaria · Canada - RecruitingPHASE3
eValuating the Efficacy and Safety of InitiatinG depemokImab earLy therApy iN Chronic Obstructive Pulmonary Disorder (COPD) With Type 2 Inflammation
This study is testing a new medicine, depemokimab, for people with moderate to severe COPD that involves a specific type of inflammation. We want to see if starting this medicine early helps improve their breathing and reduce flare-ups.
For: Pulmonary Disease, Chronic ObstructiveUnited States · Australia · Bulgaria - Active not recruitingPHASE3
Rilvegostomig + Chemotherapy as Adjuvant Therapy for Biliary Tract Cancer After Resection (ARTEMIDE-Biliary01)
This study is for people who have had surgery for bile duct cancer. It's testing a new medicine called rilvegostomig with chemotherapy, to see if it stops the cancer from coming back. It compares the new medicine to a dummy pill.
For: Biliary Tract CancerUnited States · Australia · Belgium - Active not recruitingPHASE3
Capivasertib+Fulvestrant vs Placebo+Fulvestrant as Treatment for Locally Advanced (Inoperable) or Metastatic HR+/HER2- Breast Cancer
This study is looking at a new combination of medicines, capivasertib and fulvestrant, for women and men with a specific type of advanced breast cancer. It compares this combination to fulvestrant plus a dummy drug to see if it works better.
For: Locally Advanced (Inoperable) or Metastatic Breast CancerUnited States · Argentina · Australia - Active not recruitingPHASE3
A Phase III Study to Evaluate the Efficacy and Safety of Benralizumab in Patients With Hypereosinophilic Syndrome (HES)
This study looks at a new drug called benralizumab for Hypereosinophilic Syndrome (HES) in people aged 12 and over. It compares benralizumab to a dummy drug to see if it's safe and helps reduce HES symptoms.
For: Hypereosinophilic SyndromeUnited States · Argentina · Austria - RecruitingPHASE3
A Research Study to Look at How Well NNC0487-0111 Works Compared to Placebo in People With Heart Failure and Obesity
This study looks at a new medicine, NNC0487-0111, for people with heart failure and obesity. It compares the medicine to a dummy treatment (placebo) to see if it's safe and helps improve heart health.
For: Obesity · Heart FailureUnited States · Argentina · Australia - Active not recruitingPHASE3
A Study of Belzutifan (MK-6482) Plus Pembrolizumab (MK-3475) Versus Placebo Plus Pembrolizumab in Participants With Clear Cell Renal Cell Carcinoma Post Nephrectomy (MK-6482-022)
This study is comparing two treatments, belzutifan plus pembrolizumab, against pembrolizumab alone, for kidney cancer that has been removed. It aims to see if the combination treatment can prevent the cancer from returning.
For: Carcinoma, Renal CellUnited States · Australia · Brazil - Active not recruitingPHASE3
Study Of Venetoclax Tablet With Intravenous or Subcutaneous Azacitidine to Assess Change in Disease Activity In Adult Participants With Newly Diagnosed Higher-Risk Myelodysplastic Syndrome
This study looks at a new drug, venetoclax, combined with existing treatment, azacitidine, for adults with a type of blood disorder called higher-risk Myelodysplastic Syndrome (MDS). It aims to see if this combination is safe and effective compared to azacitidine alone.
For: Myelodysplastic Syndrome (MDS)United States · Australia · Austria - RecruitingPHASE3
Efficacy and Safety of a New Formulation of Oral Cladribine Compared With Placebo in Participants With Generalized Myasthenia Gravis (MyClad)
This study is testing a new medicine, cladribine, in pill form for people with a muscle weakening condition called myasthenia gravis. We want to see if it helps and if it's safe compared to a dummy pill. We're also looking at its long-term effects and how the body uses the medicine.
For: Generalized Myasthenia GravisUnited States · Argentina · Australia - Active not recruitingPHASE3
Quizartinib or Placebo Plus Chemotherapy in Newly Diagnosed Patients With FLT3-ITD Negative AML
This study is looking at a new drug, quizartinib, combined with standard chemotherapy for adults recently diagnosed with a specific type of leukaemia called AML. We want to see if this combination improves treatment outcomes compared to chemotherapy alone.
For: LeukemiaUnited States · Australia · Austria - Active not recruitingPHASE1, PHASE2
Brainshuttle AD: A Multiple Ascending Dose Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of RO7126209 Following Intravenous Infusion in Participants With Prodromal or Mild to Moderate Alzheimer's Disease
This study is testing a new drug called RO7126209 for people with early Alzheimer's disease. We want to see how safe it is, how well the body handles it, and if it affects the disease. Participants will receive the drug intravenously.
For: Alzheimers DiseaseUnited States · Australia · Canada - RecruitingPHASE3
A Study to Evaluate Axatilimab and Corticosteroids as Initial Treatment for Chronic Graft-Versus-Host Disease
This study is looking at a new medicine called axatilimab, alongside standard steroids, for people with chronic graft-versus-host disease (cGVHD). It compares axatilimab with a dummy medicine (placebo) to see how well it works to treat this condition.
For: Chronic Graft-versus-host-diseaseUnited States · Australia · Austria - Active not recruitingPHASE3
Global Safety and Efficacy Registration Study of Crinecerfont in Pediatric Participants With Classic Congenital Adrenal Hyperplasia (CAHtalyst Pediatric Study)
This study is testing a new medicine, crinecerfont, for children and teenagers aged 2 to 17 with a type of Congenital Adrenal Hyperplasia (CAH). It compares the new medicine to a dummy pill (placebo) to see how well it works and if it's safe.
For: Congenital Adrenal HyperplasiaUnited States · Belgium · Canada - RecruitingPHASE2
Study of S-606001 as an Add-on to Enzyme Replacement Therapy (ERT) in Participants With Late-onset Pompe Disease (LOPD)
This study is testing a new medicine, S-606001, for people with late-onset Pompe disease who are already on treatment. It looks at how safe the new medicine is, how it works in the body, and if it helps improve symptoms.
For: Pompe DiseaseUnited States · Belgium · Denmark - Active not recruitingPHASE2
Study to Evaluate Safety, Tolerability and Drug Levels of BMS-986435/MYK-224 in Participants With Heart Failure With Preserved Ejection Fraction (HFpEF)
This study is looking into a new medication called BMS-986435/MYK-224 for people with a type of heart failure called HFpEF. Researchers want to see if it's safe, how well people tolerate it, and how much of the medicine stays in the body.
For: Heart FailureUnited States · Argentina · Canada - RecruitingPHASE3
An Induction Study to Investigate the Efficacy and Safety of Duvakitug in Participants With Moderately to Severely Active Crohn's Disease
This study is testing a new medicine called Duvakitug for people with Crohn's disease that isn't well controlled. It compares Duvakitug to a dummy medicine to see if it's safe and effective in improving symptoms for those with moderately to severely active Crohn's.
For: Crohn's DiseaseUnited States · Argentina · Australia - Active not recruitingPHASE3
A Phase III Study to Assess the Effect of AZD0780 on LDL-C in Patients With Clinical ASCVD or at Risk for a First ASCVD Event
This study looks at a new drug, AZD0780, for people with heart disease or who are at risk of it, and who have high 'bad' cholesterol (LDL-C). We want to see if AZD0780 safely lowers this cholesterol.
For: Cardiovascular DiseaseUnited States · Argentina · Australia - RecruitingPHASE2, PHASE3
Phase 2/3 Study of Participants With Recurrent Pericarditis Evaluating the Efficacy and Safety of KPL-387
This study is testing a new medicine, KPL-387, for people with recurrent pericarditis, a condition causing chest pain and inflammation around the heart. We want to see if it's safe and helps reduce symptoms and prevent the problem from coming back.
For: Pericarditis · Pericarditis Acute · Recurrent PericarditisUnited States · Canada · France - RecruitingPHASE3
A 52-week Study of Rilzabrutinib Efficacy and Safety Compared to Placebo in Adults Diagnosed With IgG4-related Disease
This study is looking into a new medication, rilzabrutinib, for adults with a condition called IgG4-related disease. It compares the medication to a dummy pill to see if it's safe and helps control the disease over 52 weeks.
For: Immunoglobulin G4 Related DiseaseUnited States · Argentina · Belgium - RecruitingPHASE3
A Phase III Study to Investigate the Efficacy and Safety of Elecoglipron Compared With Placebo in Adults With Type 2 Diabetes Mellitus and Impaired Renal Function on Background Dapagliflozin
This study is testing a new medicine, Elecoglipron, for adults with type 2 diabetes and kidney problems. It compares Elecoglipron to a dummy pill (placebo) to see if it's safe and effective when taken with other usual diabetes medicines, including dapagliflozin.
For: Type 2 Diabetes Mellitus · Type 2 Diabetes With Chronic Kidney DiseaseUnited States · Bulgaria · China - RecruitingPHASE3
A Clinical Study to Evaluate the Effects of Enicepatide (RO7795068) in Participants With Obesity or Overweight Without Type 2 Diabetes
This study is testing a new medicine, enicepatide, for people who are overweight or have obesity but do not have type 2 diabetes. It aims to see if the medicine helps with weight loss and if it's safe compared to a dummy medicine.
For: Obesity or OverweightUnited States · Argentina · Australia - Active not recruitingPHASE2
Long-term Follow-up Study to Evaluate Durability of Treatment Response in Previous Bepirovirsen Study Participants (B-Sure)
This study is checking if the benefits of bepirovirsen for Hepatitis B last over time. It's for people who previously took part in a bepirovirsen trial and showed good results. No new treatment is given in this follow-up study, just monitoring.
For: Hepatitis BUnited States · Argentina · Australia - Not yet recruitingPHASE3
A Study to Investigate Outcomes With Elecoglipron Compared With Placebo in Adult Participants With Chronic Kidney Disease.
This study looks at a new medicine called elecoglipron for people with long-term kidney disease. We want to see if it helps improve health compared to a dummy pill (placebo). Participants will also be taking existing kidney disease treatments like dapagliflozin. It's a large study, involving many people to get clear results.
For: Chronic Kidney DiseaseUnited States · Argentina · Australia - RecruitingPHASE3
A Study of Efficacy and Safety of Depemokimab Compared With Placebo in Adults and Adolescents With at Risk Type 2 Asthma
This study is testing a new medicine called Depemokimab for people aged 12 and over with a type of asthma that often causes flare-ups. It aims to see if this new medicine can help reduce these flare-ups better than usual treatments or a dummy medicine.
For: AsthmaUnited States · United Kingdom - Active not recruitingPHASE3
A Global Study to Assess the Effects of Durvalumab With Oleclumab or Durvalumab With Monalizumab Following Concurrent Chemoradiation in Patients With Stage III Unresectable Non-Small Cell Lung Cancer
This study is for people with a type of lung cancer that can't be removed by surgery. It tests new drug combinations (Durvalumab with Oleclumab, or Durvalumab with Monalizumab) after standard treatment to see if they can help stop the cancer from coming back or getting worse.
For: Non-Small Cell Lung CancerUnited States · Australia · Brazil - Active not recruitingPHASE2
Efficacy and Safety of GSK4527226 [AL101] in Participants With Early Alzheimer's Disease
This study is testing a new medicine, GSK4527226, for people in the early stages of Alzheimer's disease. Researchers want to see if it's safe and helps improve or slow down symptoms compared to a dummy medicine.
For: Alzheimer's DiseaseUnited States · Argentina · Australia - Active not recruitingPHASE3
Assessing the Impact of Lipoprotein (a) Lowering With Pelacarsen (TQJ230) on Major Cardiovascular Events in Patients With CVD
This study is looking into a new medication called Pelacarsen. It aims to see if this medicine can help people with heart disease who have high levels of a specific type of 'bad' cholesterol (Lipoprotein(a)) reduce their risk of future heart problems.
For: Cardiovascular Disease and Lipoprotein(a)United States · Argentina · Australia - Active not recruitingPHASE3
Durvalumab With Stereotactic Body Radiation Therapy (SBRT) vs Placebo With SBRT in Early Stage Unresected Non-small Cell Lung Cancer (NSCLC) Patients/ Osimertinib Following SBRT in Patients With Early Stage Unresected NSCLC Harboring an EGFR Mutation
This study is looking at new ways to treat early-stage lung cancer that hasn't spread. It's testing if a drug called durvalumab, or another drug called osimertinib, when given after standard radiation therapy, can help improve outcomes for patients.
For: Carcinoma, Non-Small-Cell LungUnited States · Australia · Belgium - RecruitingPHASE2
A Study of Brenipatide (LY3537031) in Participants With Irritable Bowel Syndrome-Diarrhea (IBS-D)
This study is looking at a new medicine called brenipatide (LY3537031) for people with irritable bowel syndrome who mostly have diarrhea (IBS-D). We want to see if it's safe, what side effects it might cause, and if it helps reduce symptoms.
For: Irritable Bowel Syndrome · DiarrheaUnited States · Belgium · Canada - RecruitingPHASE2
SAFety and Efficacy of Human Anti-thymocyte ImmunoGlobUlin SAB-142 ARresting Progression of Type 1 Diabetes
This study is testing a new drug, SAB-142, for people with recently diagnosed Type 1 Diabetes. It aims to see if SAB-142 can slow down the disease, and if it's safe to use. Participants will receive high dose, low dose, or a dummy drug.
For: Type 1 DiabetesUnited States · Australia · Austria - Active not recruitingPHASE1, PHASE2
Safety, Tolerability, Pharmacodynamic, Efficacy, and Pharmacokinetic Study of DYNE-251 in Participants With Duchenne Muscular Dystrophy Amenable to Exon 51 Skipping
This study is looking at a new medicine called DYNE-251 for boys aged 4-16 with Duchenne Muscular Dystrophy (DMD). It aims to see if the medicine is safe, well-tolerated, and helps the body make more dystrophin protein.
For: Duchenne Muscular Dystrophy (DMD)United States · Australia · Belgium - Active not recruitingPHASE3
Capivasertib+Abiraterone as Treatment for Patients With Metastatic Hormone-sensitive Prostate Cancer and PTEN Deficiency
This study looks at a new drug, capivasertib, combined with standard treatment (abiraterone and ADT) for men with prostate cancer that has spread and is sensitive to hormone treatment. It's for men whose cancer has a specific change called PTEN deficiency.
For: Hormone-Sensitive Prostate CancerUnited States · Argentina · Australia - RecruitingPHASE3
A Study to Test the Efficacy and Safety of Riliprubart Against the Usual Treatment of Intravenous Immunoglobulin (IVIg) in People With Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)
This study is testing a new medicine, riliprubart, against the usual treatment for Chronic Inflammatory Demyelinating Polyneuropathy (CIDP). It's for adults already receiving IVIg to see if riliprubart works safely and effectively to manage their condition.
For: Chronic Inflammatory Demyelinating PolyneuropathyUnited States · Argentina · Belgium - Active not recruitingPHASE3
A Study to Evaluate the Efficacy and Safety of Obinutuzumab in Participants With ISN/RPS 2003 Class III or IV Lupus Nephritis
This study is looking at a new medicine called obinutuzumab for people with a serious kidney problem called lupus nephritis. Researchers want to see if it's safe and helps better than a dummy medicine when added to usual treatments, like steroids.
For: Lupus NephritisUnited States · Argentina · Brazil - Active not recruitingPHASE3
Efficacy and Safety Study of Frexalimab (SAR441344) in Adults With Nonrelapsing Secondary Progressive Multiple Sclerosis
This study is testing a new drug called frexalimab for people with a type of multiple sclerosis (MS) called non-relapsing secondary progressive MS (nrSPMS). Researchers want to see if it can slow down MS progression and if it's safe. It's compared to a dummy drug (placebo).
For: Multiple SclerosisUnited States · Argentina · Australia - RecruitingPHASE2
A Phase 2 Trial of ALN-APP in Patients With Cerebral Amyloid Angiopathy
This study is looking at a new medicine called ALN-APP for a condition called Cerebral Amyloid Angiopathy (CAA). It aims to see how well ALN-APP works to slow down CAA and if it's safe. Participants will either receive the new medicine or a dummy treatment.
For: Cerebral Amyloid AngiopathyUnited States · Australia · Canada - RecruitingPHASE2
A Phase 2 Study to Evaluate Povetacicept in Adults With Generalized Myasthenia Gravis
This study is testing a new medicine, Povetacicept, for people aged 18 to 80 with a type of muscle weakness called generalized myasthenia gravis (gMG). Researchers want to see how the medicine works in the body and if it's safe to use.
For: Myasthenia Gravis, GeneralizedUnited States · Australia · Poland - RecruitingPHASE2
Efficacy and Safety of IMVT-1402 in Adult Participants With Primary Sjogren's Disease With Moderate to Severe Systemic Disease Activity
This study is testing a new drug, IMVT-1402, for adults with a moderate to severe form of Sjögren's Syndrome. It aims to see if the drug is safe and helps reduce symptoms compared to a dummy drug (placebo) over 24 weeks.
For: Primary Sjögren's SyndromeUnited States · Argentina · Brazil - Active not recruitingPHASE1
A Study for GSK3862995B in Healthy Participants and Participants With Chronic Obstructive Pulmonary Disease
This study is testing a new medicine, GSK3862995B, for safety in healthy people and those with Chronic Obstructive Pulmonary Disease (COPD). It aims to see how well people tolerate the medicine and if it causes any side effects, starting with small doses.
For: Pulmonary Disease, Chronic ObstructiveUnited States · Germany · United Kingdom - RecruitingPHASE3
BEATRIX: A Study to Learn About a Group B Streptococcus Vaccine in Healthy Pregnant Women and Their Babies
The BEATRIX study is looking at a vaccine for Group B Streptococcus (GBS) in pregnant women and their babies. It aims to understand if the vaccine is safe and how well it works to protect against GBS, a common bacteria that can sometimes cause serious infections.
For: HealthyUnited States · Argentina · Brazil - Active not recruitingPHASE3
A Study of JNJ-77242113 in Adolescent and Adult Participants With Moderate to Severe Plaque Psoriasis
This study is looking into a new treatment called JNJ-77242113 for moderate to severe plaque psoriasis in teenagers and adults. We want to see how well it works to improve skin symptoms. It's a Phase 3 trial, meaning it's a key step in testing this potential new medicine.
For: Plaque PsoriasisUnited States · Argentina · Australia - Active not recruitingPHASE3
Study of Elafibranor in Patients With Primary Biliary Cholangitis (PBC)
This study is testing a new drug, elafibranor, for people with a liver condition called Primary Biliary Cholangitis (PBC). It aims to see if the drug can improve liver health and reduce symptoms like itching and tiredness compared to a dummy treatment.
For: Primary Biliary CirrhosisUnited States · Argentina · Belgium - Active not recruitingPHASE3
Phase 3 Study to Evaluate Ianalumab on Top of Standard-of-care Therapy in Patients With Systemic Lupus Erythematosus (SIRIUS-SLE 2)
This study is testing a new drug called ianalumab for people with lupus (SLE). It aims to see if ianalumab, given alongside usual lupus treatments, is safe and helps improve symptoms. It's for adults and some teenagers with active lupus.
For: Systemic Lupus ErythematosusUnited States · Argentina · Australia - Active not recruitingPHASE3
Study Evaluating Tarlatamab After Chemoradiotherapy in Limited-Stage Small-Cell Lung Cancer (LS-SCLC)
This study looks at a new drug, Tarlatamab, for people with a type of lung cancer called limited-stage small-cell lung cancer (LS-SCLC). It aims to see if Tarlatamab can help people live longer without their cancer getting worse after chemotherapy and radiotherapy.
For: Limited Stage Small Cell Lung Cancer · Small Cell Lung CancerUnited States · Argentina · Australia - Active not recruitingPHASE2
Study to Evaluate the Efficacy, Safety, and Tolerability of an Anti-MTBR Tau Monoclonal Antibody (BMS-986446) in Participants With Early Alzheimer's Disease
This study is looking into a new medication called BMS-986446 for people in the early stages of Alzheimer's disease. Researchers want to see if it helps with memory and thinking, if it's safe to use, and if people can take it without too many problems. It's a new treatment being tested.
For: Alzheimer Disease, Early OnsetUnited States · Australia · Belgium