Placebo Administration clinical trials
10 indexed studies · 4 currently recruiting
- Active not recruitingPHASE2
Aspirin in Preventing Disease Recurrence in Patients With Barrett Esophagus After Successful Elimination by Radiofrequency Ablation
This study looks at whether a daily low-dose aspirin can stop Barrett's oesophagus from coming back after successful treatment. We're also checking how safe aspirin is and tracking specific body markers that might show if the condition is returning.
For: Barrett Esophagus · Esophageal AdenocarcinomaUnited States · Canada - Active not recruitingPHASE2
Testing the Addition of the Drug Relugolix to the Usual Radiation Therapy for Advanced-Stage Prostate Cancer, The NRG Promethean Study
This study looks at combining a drug called relugolix with usual radiation therapy for advanced prostate cancer that has spread to limited other areas. It aims to see if this combination helps stop the cancer from spreading further compared to radiation alone.
For: Oligometastatic Prostate Carcinoma · Prostate Adenocarcinoma · Prostate Ductal AdenocarcinomaUnited States · Canada - Active not recruitingPHASE2
Metformin for the Prevention of Oral Cancer in Patients With Oral Leukoplakia or Erythroplakia
This study investigates if metformin, a common diabetes drug, can prevent oral cancer in people with white or red patches in their mouth (leukoplakia or erythroplakia). Participants will take either metformin or a dummy pill for 24 weeks.
For: Erythroplakia · Oral LeukoplakiaUnited States · Canada - Active not recruitingPHASE3
T-DM1 and Tucatinib Compared With T-DM1 Alone in Preventing Relapses in People With High Risk HER2-Positive Breast Cancer, the CompassHER2 RD Trial
This study looks at two medicines, T-DM1 and tucatinib, to see if combining them is better than T-DM1 alone at stopping high-risk HER2-positive breast cancer from coming back. It focuses on people who still have some cancer cells after their first treatment.
For: Anatomic Stage IA Breast Cancer AJCC v8 · Anatomic Stage II Breast Cancer AJCC v8 · Anatomic Stage IIA Breast Cancer AJCC v8United States · Canada · Puerto Rico - RecruitingPHASE2
MYELOMATCH: A Screening Study to Assign People With Myeloid Cancer to a Treatment Study or Standard of Care Treatment Within myeloMATCH (MyeloMATCH Screening Trial)
This study helps doctors find the best treatments for people with certain blood cancers like leukaemia. It uses special tests on blood and bone marrow to match patients with personalised treatments or standard care, aiming to improve how cancer treatments are chosen.
For: Acute Myeloid Leukemia · Acute Myeloid Leukemia Arising From Previous Myelodysplastic/Myeloproliferative Neoplasm · Acute Myeloid Leukemia Post Cytotoxic TherapyUnited States · Canada · Puerto Rico - RecruitingPHASE3
Hydrocortisone and Fludrocortisone for Critical Illness-related Corticosteroid Insufficiency
This study is testing if a combination of hydrocortisone and fludrocortisone can help critically ill adults struggling with a specific type of hormone imbalance. It compares these medications to a dummy treatment (placebo) to see if they improve recovery in intensive care.
For: Critical Illness Related Corticosteroids InsufficiencyFrance - Active not recruitingPHASE3
Lactobacillus Plantarum in Preventing Acute Graft Versus Host Disease in Children Undergoing Donor Stem Cell Transplant
This study looks at whether a good bacteria (Lactobacillus plantarum) can help prevent a serious problem called graft versus host disease in children and young adults having a stem cell transplant. Patients will either get the good bacteria or a dummy treatment.
For: Acute Graft Versus Host Disease · Hematopoietic and Lymphatic System Neoplasm · LeukemiaUnited States · Canada - RecruitingPHASE2
Intravenous Dexmedetomidine as an Adjuvant to Locoregional Anesthesia in Pediatric Surgery
This study looks at whether a medicine called dexmedetomidine, given during surgery, can help reduce pain after operations in children aged 1 to 7. It aims to see if it helps with pain, reduces the need for strong painkillers, and improves recovery.
For: Anesthesia · Pediatric SurgeryFrance - RecruitingPHASE2
Using Nivolumab Alone or With Cabozantinib to Prevent Mucosal Melanoma Return After Surgery
This study looks at new ways to treat a rare type of skin cancer called mucosal melanoma, found inside the body. It tests if a drug called nivolumab, alone or with another drug called cabozantinib, can stop the cancer from coming back after surgery or help those where surgery wasn't enough.
For: Anal Melanoma · Bladder Melanoma · Cervical MelanomaUnited States · Canada - Active not recruitingPHASE3
Testing the Addition of the Immunotherapy Drug Pembrolizumab to the Usual Chemotherapy Treatment (Paclitaxel and Carboplatin) in Stage III-IV or Recurrent Endometrial Cancer
This study is testing if adding an immunotherapy drug called pembrolizumab to standard chemotherapy (paclitaxel and carboplatin) works better for advanced or returning womb cancer. It aims to see if this new combination helps patients more than chemotherapy alone.
For: Endometrial Clear Cell Adenocarcinoma · Endometrial Dedifferentiated Carcinoma · Endometrial Endometrioid AdenocarcinomaUnited States · Canada · Japan