- Active not recruitingPHASE3
A Study to Test an Oral Medicine, Belumosudil, in Combination With Corticosteroids in Participants at Least 12 Years of Age With Newly Diagnosed Chronic Graft Versus Host Disease.
This study is testing a new medicine, Belumosudil, alongside standard steroids for people aged 12 and over newly diagnosed with chronic Graft-versus-Host Disease (cGVHD). We want to see if this combination works better to manage the condition.
For: Chronic Graft Versus Host DiseaseUnited States · Argentina · Australia - RecruitingPHASE1, PHASE2
A Study to Evaluate the Safety, Tolerability, and Efficacy of MORAb-202 (Herein Referred to as Farletuzumab Ecteribulin), a Folate Receptor Alpha (FRα)-Targeting Antibody-drug Conjugate (ADC) in Participants With Selected Tumor Types
This study is testing a new drug, Farletuzumab Ecteribulin, for certain advanced cancers like ovarian, endometrial, and some breast and lung cancers. Researchers want to see if it's safe, how well it works, and find the best dose.
For: Solid TumorUnited States · France · Japan - Active not recruitingPHASE2, PHASE3
Systemic Therapy in Advancing or Metastatic Prostate Cancer: Evaluation of Drug Efficacy
This study, called STAMPEDE, looks for better ways to treat prostate cancer that is spreading or has a high chance of spreading. It tests new treatments against standard ones to help men live longer and have a better quality of life.
For: Prostate CancerSwitzerland · United Kingdom - RecruitingPHASE2
A Phase 2 Study to Evaluate the Effects of ASP5541 in Participants With Prostate Cancer
This study looks at a new injection, ASP5541, for advanced prostate cancer that has spread. It compares ASP5541 to a standard tablet treatment, abiraterone acetate, to see how safe and effective it is.
For: Prostate Cancer · Metastatic Castration-Resistant Prostate Cancer · Metastatic Hormone Sensitive Prostate CancerUnited States · China · France - RecruitingPHASE3
Treatment Protocol for Children and Adolescents With Acute Lymphoblastic Leukemia - AIEOP-BFM ALL 2017
This study looks at new ways to treat childhood leukaemia (ALL) in children and teenagers. It aims to make treatments kinder and more effective by using smart medicines (immunotherapy) and targeting specific cancer features, reducing the need for harsh chemotherapy.
For: Acute Lymphoblastic Leukemia, PediatricAustralia · Austria · Czechia - Active not recruitingPHASE2
A Study of Revumenib in Combination With Chemotherapy for Patients Diagnosed With Relapsed or Refractory Leukemia
This study looks at a new drug, revumenib, with chemotherapy for babies and young children (under 6) with a type of leukaemia that has come back or isn't responding well to treatment, especially if they have a specific gene change.
For: Recurrent Acute Leukemia of Ambiguous Lineage · Recurrent Acute Lymphoblastic Leukemia · Recurrent Acute Myeloid Leukemia Due to Lineage Switch From Acute Leukemia of Ambiguous LineageUnited States · Canada - RecruitingPHASE3
International Cooperative Treatment Protocol for Children and Adolescents With Lymphoblastic Lymphoma
This study looks at new ways to treat a type of cancer in children and teenagers called lymphoblastic lymphoma. It compares different medications and treatment approaches to find the most effective and safest options for patients in the UK and other countries.
For: Lymphoblastic Lymphoma, ChildhoodAustria · Belgium · China - RecruitingPHASE3
Efficacy and Safety of Infliximab for Immune Checkpoint Inhibitor Induced Colitis
This study looks at a new way to treat bowel inflammation (colitis) caused by cancer medicines called immune checkpoint inhibitors. It compares standard steroids with steroids plus a drug called infliximab to see which works best and fastest.
For: ColitisDenmark · United Kingdom - RecruitingPHASE3
A Study to Test Whether Spesolimab Helps People With a Skin Condition Called Pyoderma Gangrenosum
This study is testing a new medicine called spesolimab for a skin condition called pyoderma gangrenosum (PG). It aims to see if spesolimab can help heal PG ulcers. Adults with specific types of PG ulcers can take part.
For: Pyoderma GangrenosumUnited States · Argentina · Australia - RecruitingPHASE3
PROlonged Corticosteroid Treatment or N-ACetylcysteine for Severe Alcoholic Hepatitis
This study looks at new ways to treat severe alcoholic hepatitis. We are testing if a longer course of a common steroid (prednisolone) or adding another medicine called N-acetylcysteine can improve outcomes and reduce liver damage.
For: Alcoholic HepatitisFrance - RecruitingPHASE3
High Dose Steroids in Children With Stroke
This study looks at whether strong anti-inflammatory medicines (steroids) can help children recover from a type of stroke called focal cerebral arteriopathy (FCA). Scientists want to see if steroids, given alongside standard care, lead to better and faster recovery.
For: Paediatric StrokeAustralia · Austria · Denmark - RecruitingPHASE3
A Study to Evaluate Zilovertamab Vedotin (MK-2140) Combination With Rituximab Plus Cyclophosphamide, Doxorubicin, and Prednisone (R-CHP) Versus Rituximab Plus Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone (R-CHOP) in Participants With Previously Untreated DLBCL (MK-2140-010)
This study looks at a new drug, zilovertamab vedotin, combined with standard treatment for a type of blood cancer called diffuse large B-cell lymphoma (DLBCL). Researchers want to see if this new combination helps people live longer without their cancer growing or spreading, compared to standard treatment alone.
For: Diffuse Large B-Cell LymphomaUnited States · Argentina · Australia - RecruitingPhase III
Testing oral corticosteroids versus placebo for the treatment of fibrotic hypersensitivity pneumonitis
This study tests if steroids (prednisolone) can help people with a serious lung condition called fibrotic hypersensitivity pneumonitis (FHP). FHP causes lung scarring and breathing difficulties. We want to see if steroids improve lung function and quality of life for those newly diagnosed.
For: Fibrotic hypersensitivity pneumonitisUnited Kingdom · England - Active not recruitingPHASE2
A Trial of CHOP-R Therapy, With or Without Acalabrutinib, in Patients With Newly Diagnosed Richter's Syndrome
This study is testing a new drug, acalabrutinib, alongside the usual treatment (CHOP-R) for Richter's Syndrome. It aims to see if this combination improves outcomes for people recently diagnosed with this aggressive blood cancer.
For: Richter SyndromeUnited Kingdom - RecruitingPHASE2
A Clinical Study of Zilovertamab Vedotin (MK-2140) Plus Rituximab Plus Cyclophosphamide, Doxorubicin, and Prednisone (R-CHP) Versus Polatuzumab Vedotin Plus R-CHP in People With Diffuse Large B-cell Lymphoma (DLBCL) (MK-2140-011/waveLINE-011)
This study compares two treatments for a fast-growing blood cancer called diffuse large B-cell lymphoma (DLBCL), specifically a type called GCB DLBCL. Researchers want to see if a new drug, zilovertamab vedotin, when combined with standard therapy, works better than another combination in shrinking the cancer.
For: Lymphoma, Large B-Cell, DiffuseUnited States · Belgium · Germany - Ongoing, recruitingTherapeutic use (Phase IV)
Transfer of prednisolone into human breast milk and plasma of breastfeeding children - A low intervention cohort study with biobanking of breast milk and plasma
This study looks at how much prednisolone medication, taken by breastfeeding mums, passes into their breast milk and then into their baby's blood. We want to understand if babies are exposed to the medicine and how much.
For: Reumatoid Arthritis, SLE, myositis, psoriatric arthritis, inflammatory bowel diseaseSweden