- Active not recruitingPHASE3
Study of Subcutaneous Epcoritamab in Combination With Intravenous Rituximab and Oral Lenalidomide (R2) to Assess Adverse Events and Change in Disease Activity in Adult Participants With Previously Untreated Follicular Lymphoma
This study is looking at a new drug, epcoritamab, combined with standard treatments for follicular lymphoma, a type of blood cancer. We want to see if this combination is safe and effective in people who haven't been treated for this condition before.
For: Follicular Lymphoma (FL)United States · Australia · Belgium - Active not recruitingPHASE3
A Study to Evaluate the Efficacy and Safety of Obinutuzumab in Participants With ISN/RPS 2003 Class III or IV Lupus Nephritis
This study is looking at a new medicine called obinutuzumab for people with a serious kidney problem called lupus nephritis. Researchers want to see if it's safe and helps better than a dummy medicine when added to usual treatments, like steroids.
For: Lupus NephritisUnited States · Argentina · Brazil - Active not recruitingPHASE1
A Study of JNJ-56021927 (ARN-509) and Abiraterone Acetate in Participants With Metastatic Castration-Resistant Prostate Cancer
This study is looking at a new prostate cancer drug, JNJ-56021927, alongside existing treatments like abiraterone acetate and prednisone. Researchers want to see if these drugs work well together, check for side effects, and find the best doses for future studies in men with advanced prostate cancer.
For: Prostatic Neoplasms · Metastatic Castration-Resistant Prostate CancerUnited States · Canada · Netherlands - Active not recruitingPHASE3
A Study to Test an Oral Medicine, Belumosudil, in Combination With Corticosteroids in Participants at Least 12 Years of Age With Newly Diagnosed Chronic Graft Versus Host Disease.
This study is testing a new medicine, Belumosudil, alongside standard steroids for people aged 12 and over newly diagnosed with chronic Graft-versus-Host Disease (cGVHD). We want to see if this combination works better to manage the condition.
For: Chronic Graft Versus Host DiseaseUnited States · Argentina · Australia - RecruitingPHASE2, PHASE3
A Study to Investigate the Efficacy and Safety of Frexalimab Versus Tacrolimus in Adults Undergoing Kidney Transplantation
This study is looking at a new medicine called frexalimab for adults having a kidney transplant. It compares frexalimab to a standard medicine, tacrolimus, to see if it's safe and works well to prevent the body rejecting the new kidney.
For: Kidney Transplant RejectionUnited States · Argentina · Australia - Active not recruitingPHASE3
A Study to Evaluate Change in Disease Activity of Subcutaneous (SC) Epcoritamab Combined With Intravenous and Oral Rituximab, Cyclophosphamide, Doxorubicin Hydrochloride, Vincristine, and Prednisone (R-CHOP) or R-CHOP in Adult Participants With Newly Diagnosed Diffuse Large B-Cell Lymphoma (DLBCL)
This study is looking into a new drug, epcoritamab, for people with a type of blood cancer called Diffuse Large B-cell Lymphoma (DLBCL). It compares epcoritamab combined with standard treatment (R-CHOP) to R-CHOP alone, to see if the new combination works better.
For: Diffuse Large B-Cell LymphomaUnited States · Australia · Austria - Active not recruitingPHASE3
A Study of Niraparib in Combination With Abiraterone Acetate and Prednisone Versus Abiraterone Acetate and Prednisone for the Treatment of Participants With Deleterious Germline or Somatic Homologous Recombination Repair (HRR) Gene-Mutated Metastatic Castration-Sensitive Prostate Cancer (mCSPC)
This study is looking at a new treatment for men with prostate cancer that has spread and is responding to hormone therapy. It combines a drug called niraparib with standard treatments (abiraterone acetate and prednisone) to see if it works better for those with specific genetic changes.
For: Metastatic Castration-sensitive Prostate CancerUnited States · Argentina · Australia - RecruitingPHASE1
Study of Zanzalintinib in Combination With Immuno-Oncology or Other Agents in Participants With Solid Tumors
This study is testing a new drug, zanzalintinib, alone and with other medicines, for people with advanced cancers like kidney, prostate, and lung cancer. It's looking at safety and if the treatment shrinks tumours.
For: Renal Cell Carcinoma (RCC) · Metastatic Castration-Resistant Prostate Cancer (mCRPC) · Urothelial Carcinoma (UC)United States · Australia · Austria - Active not recruitingPHASE3
A Study of Niraparib in Combination With Abiraterone Acetate and Prednisone Versus Abiraterone Acetate and Prednisone for Treatment of Participants With Metastatic Prostate Cancer
This study is testing a new combination of medicines, niraparib and abiraterone, with prednisone, for men with advanced prostate cancer that has spread and is resistant to hormone therapy. It compares this new combination against the standard treatment of abiraterone and prednisone to see if it works better.
For: Castration-Resistant Prostatic CancerUnited States · Argentina · Australia - Active not recruitingPHASE3
An Efficacy and Safety Study of Apalutamide (JNJ-56021927) in Combination With Abiraterone Acetate and Prednisone Versus Abiraterone Acetate and Prednisone in Participants With Chemotherapy-naive Metastatic Castration-resistant Prostate Cancer (mCRPC)
This study is looking at a new combination of medicines for men with advanced prostate cancer that has stopped responding to standard hormone therapy. It aims to see if adding a drug called apalutamide to current treatment helps men live longer without their cancer getting worse.
For: Prostatic NeoplasmsUnited States · Argentina · Australia - Active not recruitingPHASE1
A Study of Comparative Formulations of Niraparib and Abiraterone Acetate (AA) in Men With Prostate Cancer
This study is testing new ways to give medicines called niraparib and abiraterone acetate for men with advanced prostate cancer. Researchers want to see how well different forms of these drugs are absorbed by the body to help patients get the best treatment.
For: Prostatic NeoplasmsUnited States · Belgium · France - Active not recruitingPHASE2
A Study for Subjects With Prostate Cancer Who Previously Participated in an Enzalutamide Clinical Study
This study is for men with prostate cancer who are already taking enzalutamide as part of another research study. It aims to gather more information on the long-term safety of enzalutamide when it's helping them. Participants will continue their current treatment and have regular check-ups.
For: Prostate CancerUnited States · Argentina · Australia - RecruitingPHASE1, PHASE2
A Study to Evaluate the Safety, Tolerability, and Efficacy of MORAb-202 (Herein Referred to as Farletuzumab Ecteribulin), a Folate Receptor Alpha (FRα)-Targeting Antibody-drug Conjugate (ADC) in Participants With Selected Tumor Types
This study is testing a new drug, Farletuzumab Ecteribulin, for certain advanced cancers like ovarian, endometrial, and some breast and lung cancers. Researchers want to see if it's safe, how well it works, and find the best dose.
For: Solid TumorUnited States · France · Japan - RecruitingPHASE1, PHASE2
Substudy 01A: Safety and Efficacy of Opevesostat (MK-5684)-Based Treatment Combinations or Opevesostat Alone in Participants With Metastatic Castration-resistant Prostate Cancer (mCRPC) (MK-5684-01A)
This study is testing new treatments for advanced prostate cancer that has spread and no longer responds to hormone therapy. It aims to see how safe and effective a new drug, Opevesostat, is when given alone or with other medicines to men with this condition.
For: Prostatic Neoplasms, Castration-ResistantUnited States · Australia · Canada - RecruitingPHASE3
A Study of Nipocalimab or Intravenous Immunoglobulin (IVIG) in Pregnancies At Risk of Fetal and Neonatal Alloimmune Thrombocytopenia (FNAIT)
This study is looking at new ways to prevent a serious bleeding condition in babies called FNAIT. It compares a new medicine, nipocalimab, with standard treatments like IVIG, in pregnant women who have had FNAIT before. The aim is to find safer, more effective ways to protect newborns.
For: Thrombocytopenia, Neonatal AlloimmuneUnited States · Austria · Germany - RecruitingPHASE2
A Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of Obinutuzumab in Adolescents With Active Class III or IV Lupus Nephritis and the Safety and PK of Obinutuzumab in Pediatric Participants
This study is looking at a new medicine called obinutuzumab for teenagers and children aged 5 to 17 with a kidney condition called lupus nephritis. We want to see if it's safe, how well it works, and how the body uses it.
For: Lupus NephritisUnited States · Brazil · Canada - RecruitingPHASE3
Study of Opevesostat (MK-5684) Versus Alternative NHA in mCRPC (MK-5684-003)
This study is testing a new medicine, Opevesostat, for men with prostate cancer that has spread and is resistant to hormone treatment. We want to see if Opevesostat helps men live longer compared to standard hormone therapies, especially after they've had other treatments.
For: Prostate Cancer MetastaticUnited States · Argentina · Australia - Active not recruitingPHASE1, PHASE2
Phase 1/2 Clinical Trial of PR001 in Infants With Type 2 Gaucher Disease (PROVIDE)
This study is testing a new treatment, LY3884961, for babies with a serious inherited condition called Type 2 Gaucher disease. Researchers want to see if it's safe and effective. It's a long-term study, following babies for up to 5 years.
For: Gaucher Disease, Type 2United States · United Kingdom - RecruitingPHASE2
A Phase 2 Study to Evaluate the Effects of ASP5541 in Participants With Prostate Cancer
This study looks at a new injection, ASP5541, for advanced prostate cancer that has spread. It compares ASP5541 to a standard tablet treatment, abiraterone acetate, to see how safe and effective it is.
For: Prostate Cancer · Metastatic Castration-Resistant Prostate Cancer · Metastatic Hormone Sensitive Prostate CancerUnited States · China · France - RecruitingPHASE3
A Clinical Study of Ifinatamab Deruxtecan (I-DXd) in People With Metastatic Prostate Cancer (MK-2400-001)
This study is testing a new medicine, ifinatamab deruxtecan (I-DXd), for men with advanced prostate cancer that has spread and isn't responding to hormone therapy. We want to see if I-DXd helps men live longer and keeps their cancer from growing compared to standard chemotherapy.
For: Prostate Cancer · Prostatic NeoplasmsUnited States · Argentina · Australia - Active not recruitingPHASE3
Study of Cabozantinib in Combination With Atezolizumab Versus Second NHT in Subjects With mCRPC
This study looks at a new combination of drugs, cabozantinib and atezolizumab, for men with prostate cancer that has spread and is no longer responding to hormone therapy. It compares this new combination with standard hormone treatments to see if it works better.
For: Metastatic Prostate Cancer · Prostate AdenocarcinomaUnited States · Argentina · Australia - RecruitingPHASE2
Early Adalimumab Induction for Immune Checkpoint Inhibitor Associated Inflammatory Arthritis
This study looks at treating a specific type of arthritis, called immune checkpoint inhibitor-associated inflammatory arthritis (ir-IA), early with a medication called adalimumab. The aim is to see if early treatment can reduce swelling and pain, and lessen the need for steroid medicines.
For: Inflammatory Arthritis · Immune-related Adverse EventCanada - RecruitingPHASE3
Study of Mosunetuzumab Plus Lenalidomide Compared to Anti-CD20 Anti-body + Chemotherapy in Follicular Lymphoma FLIPI2-5
This study is testing a new combination of drugs, mosunetuzumab and lenalidomide, for follicular lymphoma. It compares this new treatment to standard chemotherapy for people who haven't had treatment before. The aim is to see if the new combination works better and is safe.
For: Follicular LymphomaAustria · Belgium · France - Active not recruitingPHASE3
RT or No RT Following Chemotherapy in Treating Patients With Stage III/IV Hodgkin's Disease
This study looks at whether adding radiation after chemotherapy helps people with advanced Hodgkin's disease. Researchers want to see if this combination prevents the disease from coming back or helps people live longer, compared to chemotherapy alone.
For: LymphomaBelgium · Egypt · France - Active not recruitingPHASE2, PHASE3
A Study of Abiraterone Acetate Plus Prednisone With or Without Abemaciclib (LY2835219) in Participants With Prostate Cancer
This study is looking at a new combination of medicines, abemaciclib, abiraterone acetate, and prednisone, for men with advanced prostate cancer that has spread. It aims to see if adding abemaciclib is safe and effective in treating their cancer.
For: Prostate CancerUnited States · Australia · China - RecruitingPHASE3
TACKLE-IT Trial - Treat Acute T Cell Rejection With Evidence and Confidence in Kidney Transplant Recipients
This study, TACKLE-IT, looks for the best steroid dose to treat 'rejection' in people who've had a kidney or kidney-pancreas transplant. Rejection happens when the body tries to get rid of the new organ. Too many steroids can cause problems, so finding the right amount is important.
For: Rejection; Transplant, Kidney · Rejection; Transplant, PancreasAustralia · Canada · New Zealand - Active not recruitingPHASE2
A Study to Evaluate the Safety and Efficacy of Glofitamab in Combination With Rituximab (R) Plus Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone (CHOP) in Circulating Tumor (ct)DNA High-Risk Patients With Untreated Diffuse Large B-Cell Lymphoma
This study looks at a new drug, Glofitamab, combined with standard treatment for a type of lymphoma called DLBCL. It aims to see if this new combination is safe and effective for patients who haven't been treated before and have a high-risk form of the disease.
For: LymphomaUnited States · Denmark · France - Active not recruitingPHASE2
A Study of Revumenib in Combination With Chemotherapy for Patients Diagnosed With Relapsed or Refractory Leukemia
This study looks at a new drug, revumenib, with chemotherapy for babies and young children (under 6) with a type of leukaemia that has come back or isn't responding well to treatment, especially if they have a specific gene change.
For: Recurrent Acute Leukemia of Ambiguous Lineage · Recurrent Acute Lymphoblastic Leukemia · Recurrent Acute Myeloid Leukemia Due to Lineage Switch From Acute Leukemia of Ambiguous LineageUnited States · Canada - RecruitingPHASE3
International Cooperative Treatment Protocol for Children and Adolescents With Lymphoblastic Lymphoma
This study looks at new ways to treat a type of cancer in children and teenagers called lymphoblastic lymphoma. It compares different medications and treatment approaches to find the most effective and safest options for patients in the UK and other countries.
For: Lymphoblastic Lymphoma, ChildhoodAustria · Belgium · China - Active not recruitingPHASE3
Study to Compare Axicabtagene Ciloleucel With Standard of Care Therapy as First-line Treatment in Participants With High-risk Large B-cell Lymphoma
This study compares a new treatment, axicabtagene ciloleucel, with standard care for adults recently diagnosed with high-risk large B-cell lymphoma. It aims to see if the new treatment works better as a first treatment option.
For: High-risk Large B-cell Lymphoma (LBCL)United States · Australia · Austria - Active not recruitingPHASE3
An Open-Label Study Comparing Glofitamab and Polatuzumab Vedotin + Rituximab, Cyclophosphamide, Doxorubicin, and Prednisone Versus Pola-R-CHP in Previously Untreated Patients With Large B-Cell Lymphoma
This study is looking at a new treatment called glofitamab for a type of cancer called large B-cell lymphoma. It compares this new treatment, along with other medicines, against a standard treatment for people who haven't had treatment before.
For: Large B-Cell LymphomaUnited States · Argentina · Australia - Active not recruitingPHASE3
Combination Chemotherapy With or Without Radiation Therapy in Treating Patients With Hodgkin's Lymphoma
This study looks at different chemotherapy treatments, with or without radiation, for Hodgkin's lymphoma. Researchers want to find the best way to treat this cancer, making sure treatments are effective while reducing side effects.
For: LymphomaBelgium · France · Italy - RecruitingPHASE3
A Study to Test Whether Spesolimab Helps People With a Skin Condition Called Pyoderma Gangrenosum
This study is testing a new medicine called spesolimab for a skin condition called pyoderma gangrenosum (PG). It aims to see if spesolimab can help heal PG ulcers. Adults with specific types of PG ulcers can take part.
For: Pyoderma GangrenosumUnited States · Argentina · Australia - Active not recruitingPHASE3
Tafasitamab + Lenalidomide + R-CHOP Versus R-CHOP in Newly Diagnosed High-intermediate and High Risk DLBCL Patients
This study is looking at a new treatment combination for a type of blood cancer called Diffuse Large B-cell Lymphoma (DLBCL). It combines a new drug, tafasitamab, and another drug, lenalidomide, with standard chemotherapy to see if it works better than chemotherapy alone.
For: Diffuse Large B-cell LymphomaUnited States · Argentina · Australia - Active not recruitingPHASE3
A Combination of Acalabrutinib With R-CHOP in Subjects With Previously Untreated Non-GCB DLBCL (ACE-LY-312)
This study looks at a new drug called acalabrutinib combined with standard chemotherapy (R-CHOP) for a type of blood cancer called Diffuse Large B-Cell Lymphoma, in people who haven't had treatment before. We want to see if this combination works better and is safe.
For: Diffuse Large B-Cell LymphomaUnited States · Australia · Austria - RecruitingPHASE4
Early Discontinuation of Steroid Treatment in Negative FDG-PET/CT Patients With Idiopathic Retroperitoneal Fibrosis
This study looks at treating a rare condition called idiopathic retroperitoneal fibrosis (IRF). It aims to see if patients with a 'negative' scan can stop steroid treatment sooner. We're testing if this approach is safe and effective.
For: Idiopathic Retroperitoneal FibrosisFrance - Active not recruitingPHASE3
Study to Compare the Effectiveness and Safety of Golcadomide Plus R-CHOP vs Placebo Plus R-CHOP in Participants With Previously Untreated High-risk Large B-cell Lymphoma
This study looks at a new drug, Golcadomide, combined with standard chemotherapy (R-CHOP) for a type of blood cancer called large B-cell lymphoma. It wants to see if this new combination is safer and works better than R-CHOP alone for patients who haven't been treated before and have a high-risk form of the disease.
For: Large B-cell LymphomaUnited States · Argentina · Australia - RecruitingNA
Prednisone for CRPS in Distal Radius Fracture
This study looks into whether a medicine called prednisone can help prevent a painful condition called Complex Regional Pain Syndrome (CRPS) in people who have broken their wrist. Doctors want to see if it helps reduce pain and opioid use after surgery.
For: Complex Regional Pain Syndromes · Distal Radius FracturesCanada - RecruitingPHASE2
A Study to Evaluate Adverse Events and Change in Disease Activity of Subcutaneous (SC) Epcoritamab in Combination With Oral and Intravenous Anti-Neoplastic Agents in Adult Participants With Non-Hodgkin Lymphoma
This study looks at a new drug, epcoritamab, combined with other cancer medicines, for adults with Non-Hodgkin Lymphoma. It aims to see how safe these combinations are and if they help reduce the disease. Epcoritamab is given as an injection under the skin.
For: Non-Hodgkin LymphomaUnited States · China · Czechia - RecruitingPHASE3
A Study to Evaluate Zilovertamab Vedotin (MK-2140) Combination With Rituximab Plus Cyclophosphamide, Doxorubicin, and Prednisone (R-CHP) Versus Rituximab Plus Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone (R-CHOP) in Participants With Previously Untreated DLBCL (MK-2140-010)
This study looks at a new drug, zilovertamab vedotin, combined with standard treatment for a type of blood cancer called diffuse large B-cell lymphoma (DLBCL). Researchers want to see if this new combination helps people live longer without their cancer growing or spreading, compared to standard treatment alone.
For: Diffuse Large B-Cell LymphomaUnited States · Argentina · Australia - RecruitingPHASE2
A Clinical Study of Zilovertamab Vedotin (MK-2140) Plus Rituximab Plus Cyclophosphamide, Doxorubicin, and Prednisone (R-CHP) Versus Polatuzumab Vedotin Plus R-CHP in People With Diffuse Large B-cell Lymphoma (DLBCL) (MK-2140-011/waveLINE-011)
This study compares two treatments for a fast-growing blood cancer called diffuse large B-cell lymphoma (DLBCL), specifically a type called GCB DLBCL. Researchers want to see if a new drug, zilovertamab vedotin, when combined with standard therapy, works better than another combination in shrinking the cancer.
For: Lymphoma, Large B-Cell, DiffuseUnited States · Belgium · Germany - Active not recruitingPHASE3
Study of Axicabtagene Ciloleucel Versus Standard of Care Therapy in Participants With Relapsed/Refractory Follicular Lymphoma
This study is looking at a new treatment called axicabtagene ciloleucel for follicular lymphoma that has come back or hasn't responded to other treatments. It compares this new treatment to standard care to see how well it works.
For: Relapsed/Refractory Follicular LymphomaUnited States · France · Germany - RecruitingPHASE2
Relapsed Follicular Lymphoma Randomised Trial Against Standard ChemoTherapy
The REFRACT trial explores new treatments for follicular lymphoma that has come back or not responded to previous therapy. It compares new drugs with standard care to see if they offer better results for patients.
For: Relapsed Follicular Lymphoma · Refractory Follicular LymphomaUnited Kingdom - Active not recruitingPHASE2
A Study to Evaluate the Efficacy and Safety of Golcadomide in Combination With Rituximab in Participants With Newly Diagnosed Advanced Stage Follicular Lymphoma
This study looks at a new drug, golcadomide, combined with standard treatment for follicular lymphoma that's been recently diagnosed and is advanced. We want to see how well this new combination works and if it's safe for patients.
For: Lymphoma, FollicularUnited States · Australia · Brazil