- RecruitingPHASE1
FORAGER-1: A Study of Vepugratinib (LY3866288; LOXO-435) in Participants With Cancer With a Change in a Gene Called FGFR3
This study is looking at a new medicine called LOXO-435 for cancers, especially bladder cancer, that have a specific gene change (FGFR3). It checks how safe and effective LOXO-435 is, both alone and with other standard treatments, to see if it can help patients.
For: Urinary Bladder Neoplasms · Neoplasm Metastasis · Ureteral NeoplasmsUnited States · Australia · Canada - Recruiting
A Study of Bempedoic Acid in Combination With Ezetimibe and Either Rosuvastatin or Atorvastatin in Patients With Primary Hypercholesterolemia or Mixed Dyslipidemia
This study looks at how well a combination of three medicines – bempedoic acid, ezetimibe, and either rosuvastatin or atorvastatin – works together to lower 'bad' cholesterol (LDL-C) in people with high cholesterol. It also checks for any side effects in real-life medical care.
For: Primary Hypercholesterolemiia · Mixed DyslipidemiaAustria · Belgium · Germany - Recruiting
Pharmacokinetics and Safety of Commonly Used Drugs in Lactating Women and Breastfed Infants
This study looks at how medicines mothers take get into breast milk and affect their babies. We need breastfeeding mums taking common drugs to help us learn more about drug levels in milk and babies, to ensure safer choices for mums and their infants.
For: Lactating Women on Select DOI · Breastfed Infants of Mothers on Select DOIUnited States · Canada - Not yet recruitingPHASE1
A Study in Healthy Male Participants to Compare How CHF10196 Affects How the Body Absorbs and Processes Two Commonly Used Medicines: Dabigatran, a Blood Thinner, and Rosuvastatin, a Medicine Used to Lower Cholesterol
This study looks at how a new medicine, CHF10196, might affect two common drugs: dabigatran (a blood thinner) and rosuvastatin (for cholesterol). We need healthy men to help us understand these interactions, making sure future medicines are safe when taken together.
For: Healthy Male VolunteersUnited Kingdom - Active not recruitingPHASE3
A Clinical Study of Enlicitide in Participants With High Cholesterol (MK-0616-037)
This study is testing a new medicine, enlicitide, for high cholesterol. Researchers want to see if combining enlicitide with a common cholesterol medicine, rosuvastatin, works better at lowering 'bad' cholesterol than rosuvastatin alone. It's for adults aged 18-64.
For: HyperlipidemiaUnited States · Argentina · Australia