- Recruiting
Serial Tumour Biopsies and Blood Biomarkers in Melanoma
This study aims to understand why advanced melanoma treatments stop working for some patients. We're looking at samples from tumours and blood to find clues that predict when treatments might become less effective, helping us improve future care.
For: MelanomaUnited Kingdom - RecruitingNA
Robotic Prostatectomy Artificial Intelligence Low Pressure Pain (RALP) Trial
This study looks at how different equipment used during prostate cancer surgery might affect pain. It compares two common devices that inflate the tummy to create space for the surgeon, to see if one causes less pain during and after the operation.
For: Prostate Cancer (Adenocarcinoma) · Prostate Cancer (Post Prostatectomy) · Prostate Cancer SurgeryUnited Kingdom - Active not recruitingNA
Chemotherapy and Maximal Tumor Debulking of Multi-organ Colorectal Cancer Metastases
This study looks at combining chemotherapy with different ways to remove or destroy tumours in people with advanced bowel cancer that has spread to many organs. The aim is to see if this combined approach helps people live longer and keeps cancer from growing for longer compared to chemotherapy alone.
For: Multi-organ Metastatic Colorectal CancerNetherlands · United Kingdom - RecruitingPHASE3
Surgery With or Without Neoadjuvant Chemotherapy in High Risk RetroPeritoneal Sarcoma
This study looks at whether adding chemotherapy before surgery helps people with certain types of retroperitoneal sarcoma live longer without their cancer coming back. It compares surgery alone to chemotherapy followed by surgery.
For: Retroperitoneal Sarcoma · Liposarcoma · LeiomyosarcomaUnited States · Australia · Canada - RecruitingPHASE3
A Randomized Phase III Trial of Stereotactic Ablative Radiotherapy for Patients With Up to 10 Oligometastases and a Synchronous Primary Tumor.
This study looks at a special type of strong radiation, called SABR, for people with a few small cancer spots that have spread, along with a main tumor. It compares SABR plus usual care to just usual care to see if it helps.
For: Metastatic TumorCanada · Switzerland - Active not recruiting
Preoperative Optimization of Diabetic Patients
This study looks back at records of adults with diabetes having surgery in Alberta, Canada. It aims to understand how many surgical patients have diabetes, how well their diabetes is managed before surgery (using a blood test called HbA1C), and if this management affects their recovery and hospital stay.
For: Diabetes · Surgery Related Complications RateCanada - RecruitingNA
STRatIfication of Vulvar SCC by HPV and p53 Status to Guide Excision
This study looks at treating early vulvar cancer. We want to see if checking for HPV and another marker (p53) can help doctors choose if surgery or just watching closely is best, potentially reducing treatment for some.
For: Vulvar Squamous Cell CarcinomaCanada · New Zealand - Active not recruiting
Fracture-Related Outcome Study for Operatively Treated Tibia Shaft Fractures
This study looks at how people with a common lower leg break, called a tibia shaft fracture, recover after surgery. Doctors will follow about 1000 patients to see how they heal, how much pain they have, and if there are any problems.
For: Tibial Fracture · Fracture of the Tibia Type AO/OTA 42United States · Belgium · Germany - Active not recruitingPHASE3
Study of Pembrolizumab (MK-3475) Versus Placebo in Combination With Neoadjuvant Chemotherapy & Adjuvant Endocrine Therapy in the Treatment of Early-Stage Estrogen Receptor-Positive, Human Epidermal Growth Factor Receptor 2-Negative (ER+/HER2-) Breast Cancer (MK-3475-756/KEYNOTE-756)
This study looks at a new drug, pembrolizumab, for early-stage breast cancer. It's for people with a specific type of breast cancer (ER+/HER2-). Researchers want to see if adding pembrolizumab to standard chemotherapy and hormone therapy works better than standard treatment alone.
For: Breast CancerUnited States · Australia · Belgium - Recruiting
The Effect of Bariatric Surgery on Insulin Sensitivity and Energy Metabolism
This study looks at how weight-loss surgery affects blood sugar control and how the body uses energy in people with obesity and type 2 diabetes. We want to understand how this surgery improves health, especially for the liver.
For: Obesity · Diabetes Mellitus, Type 2Germany