- RecruitingPHASE2
Surovatamig (AZD0486) as Monotherapy in Participants With Relapsed/Refractory (R/R) B-cell NHL
This study is testing a new medicine called Surovatamig for adults with certain types of B-cell non-Hodgkin lymphoma that has returned or not responded to previous treatments. It aims to see how well it works and if it's safe.
For: B-cell Non-Hodgkin Lymphoma · Follicular Lymphoma (FL) · Large B-Cell Lymphoma (LBCL)United States · Australia · Brazil - RecruitingPHASE1
Study Evaluating Safety, Tolerability, PK/PD of Surovatamig in Adult RA or SLE Participants
This study is testing a new medicine, surovatamig, for rheumatoid arthritis (RA) and lupus (SLE). We want to see if it's safe, how it works in the body, and what dose is best. It's an early-stage study in adults.
For: Rheumatoid Arthritis · Systemic Lupus ErythematosusUnited States · Australia · Belgium - RecruitingPHASE3
A Study of Surovatamig (AZD0486) Plus Rituximab in Previously Untreated Follicular Lymphoma Patients
This study looks at a new drug, Surovatamig, combined with rituximab, for people with previously untreated follicular lymphoma. It compares this new combination therapy with standard treatments to see if it works better and is safe.
For: Untreated Follicular LymphomaUnited States · Australia · Belgium - RecruitingPHASE1, PHASE2
AZD0486 as Monotherapy in B-cell Acute Lymphoblastic Leukaemia
This study is testing a new medicine called AZD0486 for people with a type of blood cancer called B-cell Acute Lymphoblastic Leukaemia (B-ALL). It aims to find out if it's safe, what dose works best, and if it can help fight the cancer when other treatments haven't worked.
For: B-cell Acute Lymphoblastic Leukemia (B-ALL)United States · Australia · Brazil - RecruitingPHASE2
A Study to Assess the Effect of Surovatamig in Adult Participants With Antibody-mediated Kidney Disease
This study is testing a new medicine, Surovatamig, for adults with a specific kidney disease called Primary Membranous Nephropathy. It will check how safe the medicine is, how well the body handles it, and if it helps treat the condition and prevent serious kidney problems.
For: Primary Membranous NephropathyUnited States · Belgium · France - RecruitingPHASE3
Surovatamig as Consolidation Therapy in Participants With Chronic Lymphocytic Leukaemia or Small Lymphocytic Lymphoma With Unmutated Immunoglobulin Heavy Chain Variable (IGHV)
This study is testing a new medicine called Surovatamig for people with certain types of chronic leukaemia or lymphoma, specifically those with 'unmutated IGHV'. It aims to see if Surovatamig, given after initial treatment, is safe and helps keep the cancer in check.
For: Chronic Lymphocytic Leukaemia or Small Lymphocytic Lymphoma With Unmutated IGHVAustralia · Canada · Turkey (Türkiye) - RecruitingPHASE1, PHASE2
A Study of AZD0486 Monotherapy or in Combination With Other Anti-Cancer Agents for Mature B-Cell Malignancies
This study is testing a new drug, surovatamig, for different types of B-cell blood cancers like leukaemia and lymphoma. Researchers want to see if it's safe and effective, either alone or with other cancer treatments.
For: Chronic Lymphocytic Leukaemia · Small Lymphocytic Lymphoma · Mantle-cell LymphomaUnited States · Australia · China