Temozolomide (TMZ) clinical trials
6 indexed studies · 4 currently recruiting
- RecruitingPHASE1, PHASE2
A Multi-Arm, Platform Trial For Relapsed Neuroblastoma
This study looks for better ways to treat neuroblastoma in children and young people when it comes back. It tests new drug combinations to improve survival and quality of life for patients and to understand the disease better.
For: Relapsed NeuroblastomaAustralia · Austria · Belgium - RecruitingPHASE1, PHASE2
Study of AZD9574 as Monotherapy and in Combination With Anti-cancer Agents in Participants With Advanced Solid Malignancies
This study tests a new drug, AZD9574, alone and with other treatments, for people with advanced cancers. It aims to see how safe it is, how the body handles it, and if it helps shrink tumours.
For: Advanced Solid MalignanciesUnited States · Australia · Germany - RecruitingPHASE2
Study of Ribociclib and Everolimus in HGG and DIPG or Ribociclib and Temozolomide in DHG, H3G34-mutant
This study is looking at new drug combinations to treat certain types of brain tumours in children and young adults. It aims to see if combining ribociclib with either everolimus or temozolomide can help patients live longer and improve their health.
For: High Grade Glioma · Diffuse Intrinsic Pontine Glioma · Anaplastic AstrocytomaUnited States · Australia · Canada - Active not recruitingPHASE1, PHASE2
Vorasidenib in Combination With Temozolomide (TMZ) in IDH-mutant Glioma
This study looks at a new drug, Vorasidenib, with a standard cancer drug, Temozolomide (TMZ), for a type of brain tumour called glioma. It aims to check if this combination is safe and how well it works.
For: IDH1-mutant Glioma · IDH2-mutant GliomaUnited States · Austria · China - Active not recruitingPHASE1, PHASE2
Glioblastoma Treatment With Irradiation and Olaptesed Pegol (NOX-A12) in MGMT Unmethylated Patients
This study looks at new ways to treat a serious type of brain cancer called glioblastoma. It combines a new drug (olaptesed pegol) with standard treatments like radiotherapy, aiming to improve outcomes for patients where usual chemotherapy isn't expected to work as well.
For: GlioblastomaGermany - RecruitingPHASE1, PHASE2
Optimal Precision TherapIes to CustoMISE Care in Childhood and Adolescent Cancer
This study looks at new ways to treat cancer in children and teenagers (up to 21 years old). It uses information from a patient's cancer cells to choose the best medicines, aiming for more personalised and effective treatments.
For: Childhood Cancer · Childhood Solid Tumor · Childhood Brain TumorAustralia · Canada