The TADPOLE trial is a multi-centre, parallel group, pragmatic phase 3 randomised controlled trial with a 9-month intern clinical trials

Comparing surgical treatments for people with early breast cancer that has spread to the armpit (axillary) lymph nodes: targeted armpit surgery (targeted axillary dissection) versus standard armpit surgery (axillary node clearance)

This study compares two armpit surgeries for early breast cancer that has spread. It aims to find out if a less extensive surgery, called targeted axillary dissection (TAD), can reduce arm swelling and pain, without increasing the risk of cancer returning, compared to the standard surgery.