- Active not recruitingNA
Intensive Weight Loss Intervention Versus Usual Care for Adults With Severe and Complex Obesity
This study compares an intensive weight loss programme, including special diets and support, with standard NHS weight management for adults with severe obesity. It aims to see which works best for health and cost.
For: ObesityDenmark · United Kingdom - RecruitingNA
Is Community Based Monitoring of Diabetic Maculopathy and Pre-proliferative Diabetic Retinopathy Safe?
This study looks at whether opticians in your local area can help check for eye problems caused by diabetes, using special scans. It aims to make it easier to get checked and reduce hospital visits, while making sure it's safe and effective.
For: Diabetes Mellitus · Diabetic Retinopathy · Diabetic MaculopathyUnited Kingdom - RecruitingNA
Platform of Randomized Adaptive Clinical Trials in Critical Illness
This study, called PRACTICAL, looks at new ways to help critically ill patients with severe breathing problems. It tests different treatments like breathing machine settings and other therapies to find the safest and most effective options for improving recovery and survival.
For: Respiratory Insufficiency · Extracorporeal Membrane Oxygenation Complication · Mechanical Ventilation Pressure HighUnited States · Australia · Canada - RecruitingNA
Protocolized Reduction of Non-resuscitation Fluids Versus Usual Care in Septic Shock Patients
This study looks at whether giving less non-emergency fluids to adults with a serious infection called septic shock is better or worse than the usual way. It aims to see if limiting these fluids helps patients recover better.
For: Septic ShockFinland · Sweden · United Kingdom - Not yet recruitingNA
Apneic Oxygenation With High-flow Nasal Oxygenation After Preoxygenation With Noninvasive Ventilation Before Intubation in Hypoxemic Patients in Intensive Care Unit.
This study looks at a new way to give oxygen during a medical procedure called intubation for very sick patients in intensive care. It aims to see if an extra oxygen boost can prevent dangerously low oxygen levels.
For: Hypoxemic Acute Respiratory FailureFrance - RecruitingPHASE3
Home-based Cycling for People With Lumbar Spinal Stenosis
This study is looking at whether home cycling can help people with lower back and leg pain from lumbar spinal stenosis. It compares cycling at home with usual care to see if it improves daily activities for people aged 50 and over.
For: Symptomatic Lumbar Spinal StenosisFrance - RecruitingNA
Paediatric Syncope in the Emergency Department
This study looks at fainting (syncope) in children and teenagers who come to the emergency department. It aims to understand why kids faint and to see if special exercises (counterpressure maneuvers) can help prevent future fainting spells.
For: Syncope, Vasovagal · Postural Orthostatic Tachycardia Syndrome · Orthostatic IntoleranceCanada - Active not recruitingNA
ARIADNE: A Study of Weight Loss for Diabetes Treatment and Wellbeing
This study looks at how a special low-calorie diet affects people with type 2 diabetes and concerns about their eating habits. We want to see if this diet helps with diabetes without causing problems with their relationship with food. It will help us understand if this diet is safe for everyone.
For: Type2diabetes · Disordered Eating · ObesityUnited Kingdom - Enrolling by invitationNA
Evaluating a Mindfulness Booster Course for Healthcare Staff
This study looks at whether a short mindfulness 'booster' course can further reduce stress in healthcare staff who have already learned mindfulness. It compares the booster course to usual wellbeing activities, checking stress levels over two months.
For: Occupational Stress or Workplace StressUnited Kingdom - RecruitingNA
Sputum-guided Treatment With Comprehensive Care Management in COPD - A Randomized-controlled Trial
This study looks at new ways to help people with COPD have fewer flare-ups. It combines personal health support and care suited to your body with regular care to see if this helps reduce hospital visits.
For: COPDCanada - Active not recruitingNA
SPIDER: A Research & QI Collaboration Supporting Practices in Improving Care for Complex Elderly Patients
This study, called SPIDER, looks at how family doctors can help older patients who take many medicines. It aims to reduce medicines that might not be helpful, improving health and reducing side effects. Doctors get support to make care better.
For: Polypharmacy · Inappropriate Prescribing · AgedCanada - RecruitingNA
Eliciting Informed Goals of Care in Elderly Patients
This study looks at a new tool to help older hospital patients and their doctors talk about future healthcare choices, especially for end-of-life care. It aims to make sure patients' wishes are understood and followed, helping them get care that matches what they want.
For: Goals of Care · Patient Preference · End of LifeCanada - Active not recruitingNA
Narrative Enhancement and Cognitive Therapy for Self-Stigma in Youth
This study looks at a new talking therapy called NECT-Y for young people with bipolar disorder or other mental health conditions. It wants to see if this therapy can help reduce self-stigma, which is negative feelings about having a mental health condition.
For: Bipolar Disorder · Multiple Mental Health ConditionsCanada - Not yet recruitingNA
Exploring Feasibility, Acceptability and Impact of Using Neurofeedback with Persons with Mild Cognitive Impairment
This study is looking into new ways to help people with mild memory and thinking problems. It's testing if special 'neurofeedback' methods, which use brain activity, are safe, helpful, and easy to use. The aim is to see if these methods can improve memory, mood, and behaviour.
For: Mild Cognitive ImpairmentCanada - RecruitingNA
Interpretation and Optimization of Nutrition in the Intensive Care Units
This study looks at how a new computer system, Nutrow-Feedim, can help seriously ill patients in intensive care get the right amount of food. It aims to reduce the gap between the nutrition doctors prescribe and what patients actually receive, potentially improving their recovery.
For: Nutritional SupportFrance - Active not recruitingNA
Attrition in Pediatric Obesity Management
This study looks at how a Family Navigation programme can help children and their families stick with their weight management plans. We want to see if having extra support reduces the number of families who stop coming to appointments. This will help us plan bigger studies in the future.
For: Child ObesityCanada - Not yet recruitingNA
Catheter Ablation for AF in Patients With Severe Mitral Regurgitation After Successful Transcatheter Mitral-Valve Repair
This study looks at whether a heart procedure called catheter ablation helps patients who have irregular heartbeats (AF) and have recently had a repair for a leaky heart valve. It compares ablation to usual care to see which is better at preventing serious heart problems.
For: Atrial Fibrillation (AF) · Mitral Valve (MV) RegurgitationGermany - RecruitingNA
Early Atrial Fibrillation Ablation for Stroke Prevention in Patients With High Comorbidity Burden (EASThigh-AFNET 11)
This study looks at whether a heart procedure called 'ablation' can better prevent serious problems like stroke or heart failure in people with an irregular heartbeat (atrial fibrillation) and other health issues, compared to standard care.
For: Atrial FibrillationAustralia · Canada · Germany - RecruitingNA
Tight Control of Gouty Arthritis Compared to Usual Care
This study aims to find the best way to manage gout. It compares a new approach where patients track their own urate levels with a smartphone app to the usual care. We want to see if the new method can reduce painful gout attacks over two years.
For: GoutUnited Kingdom - Active not recruitingNA
Intensive Weight Loss Intervention Versus Usual Care for Adults With Obesity
This study compares an intense weight loss plan against standard care for adults with obesity. The intense plan involves special diets, support, and medication. Researchers want to see which approach works best and is most cost-effective for health.
For: ObesityDenmark · United Kingdom - RecruitingNA
The LISA (Lactoferrin InStead of Antibiotics/Antifungals) Feasibility Study
This study looks at a new treatment called lactoferrin for vaginal infections like thrush and BV. It aims to see if lactoferrin pessaries could be a good alternative to antibiotics, with fewer side effects.
For: Bacterial Vaginosis · Candida VaginalUnited Kingdom - RecruitingNA
BEARS Training Package to Maximise Hearing Abilities in Older Children and Teenagers With Bilateral Cochlear Implants
This study looks at a new virtual reality game for 8-16 year olds with two cochlear implants. It aims to see if playing these games makes it easier to hear in noisy places and improves their daily lives, compared to usual care.
For: Hearing Loss, Sensorineural · Hearing Loss · DeafnessUnited Kingdom - RecruitingNA
Trial of an Exercise Intervention for Children With Haemophilia
This study looks at whether a special exercise programme can help boys aged 6-12 with haemophilia. The aim is to see if strengthening muscles can improve their joint health, reduce pain, and help them join in more activities with friends, compared to their usual care.
For: Hemophilia · Child, Only · Musculoskeletal Diseases or ConditionsUnited Kingdom