- Active not recruitingPHASE3
A Study of Zanidatamab in Combination With Chemotherapy Plus or Minus Tislelizumab in Patients With HER2-positive Advanced or Metastatic Gastric and Esophageal Cancers
This study looks at a new drug, zanidatamab, combined with chemotherapy, and sometimes another drug called tislelizumab. It aims to see if this treatment works better and is safer than standard chemotherapy for advanced stomach and gullet cancers that have HER2.
For: Gastric Neoplasms · Gastroesophageal Adenocarcinoma · Esophageal AdenocarcinomaArgentina · Australia · Belgium - RecruitingPHASE3
A Study Comparing the Efficacy and Safety of Zanidatamab to Trastuzumab, Each in Combination With Physician's Choice Chemotherapy, for the Treatment of Participants With Metastatic HER2-positive Breast Cancer
This study looks at two drug combinations for HER2-positive breast cancer that has spread. It compares a new drug, zanidatamab, with a standard drug, trastuzumab, both given with chemotherapy, to see which works best and is safest after previous treatments haven't worked.
For: Metastatic HER2-positive Breast CancerUnited States · Australia · Austria - RecruitingPHASE1, PHASE2
Beamion BCGC-1: A Study to Find a Suitable Dose of Zongertinib Used Alone and in Combination With Other Treatments to Test Whether it Helps People With Different Types of HER2+ Cancer That Has Spread
This study looks at a new drug, zongertinib, for different HER2+ cancers that have spread. Researchers want to find the best dose, alone and with other treatments, to see if it can shrink tumours.
For: Metastatic Breast Cancer · Metastatic Gastric Adenocarcinoma · Gastroesophageal Junction AdenocarcinomaUnited States · Belgium · China - RecruitingPHASE3
Personalized Medicine for Advanced Biliary Cancer Patients
This study looks at whether adding a special "targeted" drug after initial treatment for advanced bile duct cancer works better than continuing standard treatment. It customises treatment based on your tumour's unique features.
For: Biliary Tract NeoplasmsBelgium · France · United Kingdom - RecruitingPHASE2
Clinical Trial Evaluating the Activity of Zanidatamab for the Treatment of Patients With Solid Tumors With an Alteration of the HER2 Gene.
This study is testing a new drug, zanidatamab, for different cancers like lung, sarcoma, head and neck, bowel, and womb cancer. It's for people whose cancer has a specific change in the HER2 gene and hasn't responded to previous treatments.
For: Non-Small Cell Lung Cancer · Sarcoma · Head &Amp; Neck CancerFrance - RecruitingPHASE2
Zanidatamab in Combination With Pembrolizumab and Chemotherapy in HER2 and PD-L1 Positive Metastatic Gastroesophageal Adenocarcinoma (GEA) Patients
This study looks at a new combination of medicines (Zanidatamab, Pembrolizumab, and chemotherapy) for advanced stomach or food pipe cancer that has spread. It focuses on patients whose cancer has specific markers (HER2 and PD-L1 positive) and haven't had previous treatment for advanced disease.
For: Gastroesophageal Adenocarcinoma · First Line Therapy · HER2 + Gastric CancerGermany - RecruitingPHASE3
Efficacy and Safety of Zanidatamab With Standard-of-care Therapy Against Standard-of-care Therapy for Advanced HER2-positive Biliary Tract Cancer
This study is testing a new drug called Zanidatamab for people with advanced HER2-positive biliary tract cancer. It compares this new drug combined with standard treatments to standard treatments alone, to see if it's more effective and safe.
For: Biliary Tract CancerUnited States · Argentina · Belgium