Clinical Trial to Compare Oral Isotretinoin to Standard of Care in Moderate Acne Skin of Color Patients

To be part of this study, you would generally need to be a man or woman between the ages of 13 and 30. Your skin type should be darker, specifically Fitzpatrick skin types IV, V, or VI. You would also need to have moderate acne as defined by specific medical guidelines.

There are also some other requirements, like having a smartphone that can take good quality selfie pictures. You'll need to agree to take part by signing a consent form and be covered by French social security.

You wouldn't be able to join if you have very mild or very severe acne, or if you've recently taken oral isotretinoin or certain antibiotics for acne. Also, if you're pregnant, breastfeeding, or unwilling to use effective contraception (if you're a woman who could become pregnant), you wouldn't be eligible. People with certain health conditions or allergies to the study medications would also not be able to participate.

If you join this study, you will be assigned to either receive oral isotretinoin or standard acne treatment (which could include oral antibiotics like doxycycline or lymecycline, or a topical cream like tretinoin). You will have regular visits with the study team. They will assess your acne, take pictures of your skin (using your smartphone), and monitor your health with blood tests to check your blood count, liver function, and cholesterol levels. Women who can become pregnant will also have pregnancy tests. The visits and assessments will happen over approximately six months. You will be told exactly when to take your medication and how to use any creams. The overall duration of your active participation in the trial will be for six months, followed by any necessary follow-up.