RecruitingNAINTERVENTIONAL

Evaluation of the Impact of an Alteration of NAD+ Metabolism on the Renal Prognosis of Patients Admitted to Intensive Care (NI-AKI)

This study aims to understand why some very sick patients in intensive care develop kidney problems, known as acute renal failure (ARF). We know that over half of patients in intensive care get ARF, and it can lead to serious long-term health issues like chronic kidney disease or heart problems. Recent research suggests that a natural body process involving something called NAD+ might play a big role in kidney health. If NAD+ isn't made properly, it could make kidney failure more likely. This study will collect a urine sample from patients when they are admitted to intensive care. We will look at certain substances in the urine to see if they can predict who might develop ARF. This could help doctors identify at-risk patients sooner and potentially develop new ways to protect their kidneys.

At a glance

Status

Recruiting

Phase

Sponsor

Ramsay Générale de Santé

Enrolment target

150

Start

17 Mar 2025

Estimated completion

05 Dec 2025

Acute Renal Insufficiency NAD

What is this study about?

When patients are very unwell and need to be in intensive care, their bodies are often under a lot of stress. Sadly, more than half of these patients develop a sudden kidney problem called acute renal failure (ARF). This can be very serious in the short term, but even for those who recover, ARF can lead to long-lasting health issues, including serious kidney disease or heart problems later in life.

We're learning more about why ARF happens. One exciting area of research is looking at how our bodies handle a natural substance called NAD+. Think of NAD+ as a vital helper in many body processes, including those that keep our kidneys healthy. Recent studies, both in animals and in people, have hinted that if the body doesn't produce enough NAD+ correctly, it could make kidney failure more likely. Interestingly, some early findings suggest that giving patients certain B vitamins might help reduce the risk of ARF.

This study is a pioneering step to see if we can identify changes in how the body makes NAD+ as a warning sign for ARF in intensive care patients. We will be looking at specific markers in a patient's urine when they are first admitted. By understanding this connection better, we hope to find new ways to prevent ARF and improve the long-term health of patients recovering from critical illness.

Key takeaways

This study investigates why some critically ill patients develop kidney problems.
It focuses on a natural body process involving NAD+ and its link to kidney health.
Participation involves a simple urine test and a follow-up phone call.
No new medications are given, and no extra hospital visits are required.
The findings could help doctors predict and prevent kidney problems in the future.
Your medical care will not be affected by taking part.

Who may be eligible?

This study is looking for adults aged 18 or older who are admitted to intensive care. You would be considered if you have healthy kidneys when you come in, but your reason for being in intensive care puts you at a higher risk of kidney problems. This includes situations like being in shock, having a severe infection (sepsis), after a sudden cardiac arrest, or following unexpected surgery or heart surgery.

However, you couldn't join if you already have long-term kidney disease, have had a kidney transplant, or if your intensive care admission is for conditions that don't typically lead to kidney problems, such as certain head injuries or drug overdoses. Also, if you're pregnant or breastfeeding, or if you're taking part in another clinical study right now, you wouldn't be able to participate. It's really important that everyone who joins understands the study and gives their written permission freely.

Could this study suit you?

Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.

Are you 18 years old or older?
Are you currently admitted to intensive care?
Were your kidneys healthy before this admission?
Is your reason for intensive care admission considered high-risk for kidney problems (e.g., shock, severe infection, heart surgery)?
Have you given your full understanding and written permission to join the study?

Answer every question to see your result.

What does participation involve?

If you decide to take part, your involvement would be quite simple. When you're admitted to intensive care, we would collect a urine sample from you. This is a common and straightforward procedure. The only other step would be a phone call 28 days later to check how you're doing. There are no study medications to take, and no extra hospital visits beyond your usual care. The total duration of your participation in terms of direct contact would be limited to these two points.

Potential risks and benefits

Taking part in this study involves very minimal risk as it only requires a urine sample and a follow-up phone call, which are standard procedures and not expected to cause harm. There's no direct personal benefit to you from participating, as the study aims to gather information for future patient care, not to treat your current condition. However, your contribution is valuable as it will help researchers understand kidney problems better and may lead to improved care for others in the future. You always have the right to withdraw from the study at any time without affecting your medical care.

Locations (1)

Hôpital Privé de l'Ouest Parisien
Verified postcode
Trappes, France· Recruiting

Common questions

What is acute renal failure (ARF)?

ARF is a sudden and sometimes serious problem where your kidneys stop working properly. It's also known as acute kidney injury (AKI).

What is NAD+?

NAD+ is a natural helper in your body that's important for many processes, including keeping cells healthy and producing energy. Researchers think it might play a role in kidney health.

Will I have to take any new medicines?

No, this study does not involve taking any new medications. We are only collecting a urine sample and having a follow-up phone call.

How long will I be in the study?

Your direct involvement in collecting information for the study is very brief – just a urine sample when you're admitted and a phone call 28 days later.

Will this study affect my usual hospital care?

No, taking part in this study will not affect the medical care you receive for your condition.

How to find out more

Matthieu JAMME, Dr

mat.jamme@gmail.com 00336 87 64 61 12 Official trial record

Always speak to your GP or specialist before deciding to take part in a study.