AuthorisedTherapeutic confirmatory (Phase III)Interventional

TicAgreLor versus placebo to prevent cerebral ISCHemia in anEuRysmal low grade SAH A double blinded randomised controlled study TALISCHER - SAH

This study, called TALISCHER-SAH, is trying to find out if a medicine called Brilique (ticagrelor) can help prevent strokes and other circulation problems in people who have had a brain bleed caused by a burst blood vessel (aneurysm). This type of bleed is called a subarachnoid haemorrhage. Doctors will compare Brilique with a dummy pill (placebo) in a large group of patients. The main goal is to see if Brilique can reduce issues like blood clots in the brain during or soon after the aneurysm is treated. This research is important because it could help improve outcomes for people recovering from this serious condition.

At a glance

Status

Authorised

Phase

Therapeutic confirmatory (Phase III)

Sponsor

Centre Hospitalier Universitaire De Toulouse

Enrolment target

274

Start

04 Jun 2026

Aneurysmal subarachnoid hemorrhage

What is this study about?

This study, called TALISCHER-SAH, is looking into new ways to help people who have had a serious type of brain bleed. This bleed happens when a weak spot in a blood vessel in the brain, called an aneurysm, bursts. This is known as a subarachnoid haemorrhage. Even after the aneurysm is treated, there's a risk of further complications like strokes or other problems with blood flow to the brain, which can cause new or worsening symptoms. This study aims to see if a medicine called Brilique (ticagrelor) can help prevent these issues.

Brilique is a medicine that helps stop blood platelets from sticking together and forming clots. The study will compare patients who receive Brilique with those who receive a dummy pill (placebo). Neither the patients nor their doctors will know who is getting which, to ensure the results are as fair as possible. The main thing the researchers are looking at is whether Brilique can reduce problems like blood clots in the brain during or shortly after the aneurysm is treated.

Understanding if Brilique can safely reduce these complications is really important. If successful, this research could lead to better treatments and improved recovery for people who have experienced this serious type of brain bleed. It's hoped that by preventing these clots, patients may have fewer long-term problems and a better quality of life.

Key takeaways

This study investigates a medicine (Brilique) to prevent complications after a brain bleed.
It compares Brilique to a dummy pill (placebo) to see if it helps reduce blood clots and strokes.
Participation involves taking medication and attending regular health checks and scans.
The study aims to improve recovery for patients with a subarachnoid haemorrhage.
You won't know if you're receiving Brilique or the placebo.
You can withdraw from the study at any time without affecting your medical care.

Who may be eligible?

To join this study, you would generally need to be an adult, aged 18 or older. Both men and women can take part.

There will be other entry requirements that the study doctors will check carefully. These are in place to make sure the study is safe for you and that the results are clear and accurate. For example, they'll need to confirm you've recently had a subarachnoid haemorrhage from a burst aneurysm and likely meet specific medical criteria related to your health and the timing of your treatment.

Your doctor will be able to tell you all the detailed requirements and help you understand if this study might be suitable for you.

Could this study suit you?

Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.

Are you 18 years old or older?
Have you recently had a subarachnoid haemorrhage from a burst aneurysm?
Are you well enough to take part in a study?
Are you able to attend appointments for follow-up?
Do you understand that you might receive a placebo (dummy pill)?

Answer every question to see your result.

What does participation involve?

If you decide to take part in this study, you would be assigned by chance to either receive the study medicine, Brilique, or a dummy pill (placebo). You wouldn't know which one you're getting, and neither would your study doctor. You would take this medication as prescribed.

You would have several assessments during your time in the study. This would include regular checks of your health and any symptoms, and possibly brain scans (like MRI) to look for any changes in your brain. You can expect initial checks within the first 24 hours of treatment, followed by further evaluations at points like 15 days and 3 months after the start of the study. These visits are important for the research team to monitor your health and the effectiveness of the treatment. The total duration of your participation would be at least 3 months, but the specific schedule of visits will be explained in detail by the study team.

Potential risks and benefits

Taking part in any medical study has potential benefits and risks. A potential benefit of this study is that Brilique might help reduce your risk of serious complications like strokes or blood clots after an aneurysm rupture, which could improve your recovery. However, there's also the chance you could receive the dummy pill, which wouldn't offer this potential benefit. Potential risks of Brilique include bleeding, as it's a blood-thinning medication. Other known side effects, such as shortness of breath or changes in heart rhythm, would be closely monitored. You have the right to withdraw from the study at any time, for any reason, without it affecting your medical care.

Locations (1)

Some site locations are approximate. We're improving this — please verify with the trial team before travelling.

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Unverified
France

Common questions

What is a subarachnoid haemorrhage?

It's a serious type of stroke caused by bleeding on the surface of the brain, usually from a burst blood vessel called an aneurysm.

What is Brilique, and why is it being studied?

Brilique is a medicine that helps prevent blood clots. Researchers want to see if it can reduce strokes and other problems after a subarachnoid haemorrhage.

Will I know if I'm getting the medicine or a dummy pill?

No, neither you nor your doctors will know. This helps make the study results fair and accurate.

What happens if I want to stop taking part?

You can leave the study at any time, for any reason. Your decision won't affect your medical care.

What kind of tests will I have in the study?

You'll have regular medical checks and possibly brain scans like MRIs to monitor your health and how you're responding to the treatment.