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Not yet recruitingOBSERVATIONAL

Diagnosis of Women With ANOCA

This study focuses on a type of chest pain, or angina, called ANOCA. This is when someone has chest pain, but their main heart arteries aren't blocked. It's often harder to treat and affects women more than men. Historically, not enough research has focused on ANOCA in women, so we don't fully understand why it happens or how best to treat it. This new study is creating a special registry (a secure list of information) for women with ANOCA. The goal is to collect important health details over time to understand the different types of ANOCA and its impact. This information will help researchers develop better ways to diagnose and treat ANOCA for women in the future. Women in the registry may also get the chance to take part in new treatment studies.

At a glance

Status
Not yet recruiting
Sponsor
NHS Greater Glasgow and Clyde
Enrolment target
400
Start
27 Nov 2026
Estimated completion
30 Jun 2029

What is this study about?

This research study is looking at a condition called ANOCA, which stands for Angina with No Obstructive Coronary Artery Disease. In simple terms, this means you have chest pain or discomfort (angina) because your heart isn't getting enough blood, but the main arteries leading to your heart are not blocked.

ANOCA can be tricky to treat because we don't have many studies on it, especially in women. Interestingly, women are at least twice as likely as men to experience ANOCA, but most research on angina has historically focused on men. This means we don't have a full picture of how ANOCA affects women or the best ways to help them.

To fill this gap, this study is creating a special secure record, like a registry, just for women with ANOCA. The researchers want to collect information about women's health over time. This will help them understand the exact reasons why women get ANOCA, categorise the different types, and track how it affects their health. The aim is to gather crucial information that will lead to better diagnosis and more effective treatments for ANOCA in women in the future. Some women in this registry might also be invited to take part in new studies exploring potential treatments.

Key takeaways

  • This study focuses on ANOCA, a type of chest pain common in women, where heart arteries are not blocked.
  • It aims to understand ANOCA better in women by collecting health information from existing records.
  • Participation involves no extra clinic visits; data is collected remotely.
  • This research hopes to lead to better diagnosis and treatments for women with ANOCA.
  • You might be invited to future treatment studies if you join this registry.

Who may be eligible?

To be part of this registry, you need to be a woman who has been diagnosed with ANOCA. Doctors will have done specific heart tests to confirm this, like measuring your myocardial perfusion reserve or coronary flow reserve, and these results must have been recorded within the last year. You also need to be experiencing angina symptoms quite often, based on a specific health questionnaire (your score would be less than 100 on the Seattle Angina Questionnaire).

There are a few reasons why you might not be able to join. You need to be 18 years old or older. Also, it's important that you are able to understand what the study involves and agree to take part freely (this is called giving informed consent). Finally, you need to be able to follow the simple steps of the study, which mainly involves your health records being used and potentially being invited to future studies.

Could this study suit you?

Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.

  1. Are you female?
  2. Have you been diagnosed with ANOCA?
  3. Are you 18 years old or older?
  4. Are you able to understand and agree to participate?
  5. Have you had specific heart tests (like myocardial perfusion reserve or coronary flow reserve) within the last year?
  6. Do you experience angina symptoms frequently (based on a Seattle Angina Questionnaire score of less than 100)?
Answer every question to see your result.

What does participation involve?

If you decide to take part in this study, the main thing is that your existing health information will be used. This means researchers will look at details from your NHS electronic health records, such as your doctor visits, hospital stays, and the medications you take. This will help them understand how ANOCA affects women over time.

Crucially, you won't need to make any extra visits to a clinic or hospital for this study after you've joined. The researchers will gather information remotely. However, being part of this registry means you might be invited to take part in *other* future research studies that are testing new treatments for ANOCA. You would always have the choice whether or not to join those additional studies. The total duration of your participation in this registry will involve ongoing collection of your health record data over time to track long-term health.

Potential risks and benefits

Taking part in this study primarily involves using your existing health records, so there are very few direct risks to you. Your personal information will be kept strictly private and confidential. A potential benefit is that by allowing researchers to use your health data, you are helping them better understand ANOCA in women, which could lead to improved diagnosis and treatment for yourself and others in the future. You always have the right to withdraw from the study at any time, for any reason, without it affecting your medical care.

Locations (11)

  • Essex cardiothoracic centre
    Verified postcode
    Basildon, United Kingdom
  • Royal United Hospital Bath
    Verified postcode
    Bath, United Kingdom
  • Royal Papworth Hospital
    Verified postcode
    Cambridge, United Kingdom
  • Queen Elizabeth University Hospital Clinical Research Facility,
    Verified postcode
    Glasgow, United Kingdom
  • Leeds General Infirmary
    Verified postcode
    Leeds, United Kingdom
  • Brompton Hospital
    Verified postcode
    London, United Kingdom
  • Guys and St Thomas Hospital
    Verified postcode
    London, United Kingdom
  • Kings college london
    Verified postcode
    London, United Kingdom
  • Freeman Hospital
    Verified postcode
    Newcastle upon Tyne, United Kingdom
  • Nottingham City Hospital
    Verified postcode
    Nottingham, United Kingdom
  • Sunderland Royal Hospital
    Verified postcode
    Sunderland, United Kingdom

Common questions

What is ANOCA?

ANOCA stands for Angina with No Obstructive Coronary Artery Disease. It means you have chest pain, but the main arteries supplying your heart aren't blocked.

Why is this study only for women?

Women are more likely to have ANOCA, but historically, not enough research has focused on them. This study aims to understand ANOCA specifically in women.

Will I have to go to extra appointments?

No, you won't need any extra visits for this study. The researchers will gather information from your existing health records.

What happens to my personal information?

Your personal health information will be kept private and confidential, used only for research purposes by the study team.

Could I get new treatments by joining?

While this study itself doesn't offer new treatments, being part of it means you might be invited to other future studies that *are* testing new treatments for ANOCA.

How to find out more

Clare Dolan

Always speak to your GP or specialist before deciding to take part in a study.

Interested in taking part?

Register your interest

Share your details and the research team for "Diagnosis of Women With ANOCA…" will contact you if you may be eligible. Always speak to your GP before agreeing to take part.

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