Molecular Signatures in Inflammatory Skin Disease

This study is looking for adults who have already been diagnosed with a long-lasting inflammatory skin condition like eczema or psoriasis by a skin specialist (dermatologist). You would need to be currently receiving or about to start treatment with a specific type of modern medicine called a biologic, which your doctor has prescribed as part of your usual care.

To join, you must be able to understand the study information and give your written permission to take part, and you need to be able to follow the study instructions carefully. Your doctor will help determine if the specific biologic medicine you are taking or about to take is suitable for the study.

You wouldn't be able to join if you've recently used other strong immune-system medicines or light therapy (phototherapy) in the last four weeks. Also, if you've used certain creams or ointments (like strong steroid creams or calcineurin inhibitors) on the skin areas being looked at within a week before your first visit, you wouldn't be eligible. The study is open to both men and women of any age.

As this is an exploratory study, the exact details of your participation might vary, but generally, it involves providing samples of your skin and blood at several points in time. You would continue receiving your prescribed biologic medicine as usual. Each time you visit, samples would be collected for detailed analysis. The researchers would look at these samples to see how your body is responding to the treatment at a very detailed level. This might involve collecting samples over a shorter period, possibly around the time you start your new medication and as your condition changes. The total duration of your participation would depend on how frequently samples are needed and for how long, which isn't specified but typically for such pilot studies, it might range from a few weeks to a few months to track initial responses.