Thulium Fiber Laser (TFL) vs Holmium MOSES for Treatment of Benign Prostatic Hyperplasia (BPH)
This research trial is looking at two types of laser surgery for men with an enlarged prostate, known as Benign Prostatic Hyperplasia (BPH). BPH can make it difficult to pass urine. The two laser treatments being compared are the Thulium Fibre Laser (TFL) and the Holmium MOSES laser. Both methods work by removing excess prostate tissue to relieve pressure on the bladder. While a traditional surgery called TURP is common, these laser options offer benefits like less bleeding and shorter hospital stays. The main goal of this study is to find out if TFL or Holmium MOSES results in a shorter time in hospital and whether one method works better than the other during and after the operation. This will help doctors understand the best way to treat BPH.
At a glance
What is this study about?
When a man's prostate gland gets bigger as he gets older, it's called Benign Prostatic Hyperplasia, or BPH. This isn't cancer, but it can press on the tube that carries urine out of the body, causing problems like needing to go to the toilet often, struggling to start peeing, or not being able to empty the bladder fully.
Traditionally, a surgery called TURP has been very common for BPH. However, it can sometimes lead to issues like bleeding. Over the years, new laser treatments have been developed that might be gentler and have fewer side effects. One of these is the Holmium laser, especially when used with a system called MOSES, which makes it more efficient. Another newer option is the Thulium Fibre Laser (TFL). Both of these laser treatments aim to remove the excess prostate tissue without the need for large cuts, helping men pee more easily.
This study wants to compare these two advanced laser treatments – the Thulium Fibre Laser and the Holmium MOSES laser. Doctors want to see if one method helps patients recover faster, perhaps by reducing the time they need to stay in the hospital, and if there are differences in how well they work during and after the surgery. By carefully comparing these two approaches, the researchers hope to understand which one offers the best results for men with BPH. This is important for making sure patients receive the most effective and safest treatment possible in the future.
Key takeaways
- This study compares two laser treatments for an enlarged prostate (BPH).
- It aims to see which laser (Thulium Fibre Laser or Holmium MOSES) works better for recovery and results.
- BPH can cause problems with peeing but is not cancer.
- Laser treatments aim to reduce bleeding and shorten hospital stays compared to older surgeries.
- Participants must be men over 50 with a large prostate due to BPH.
- The findings will help doctors choose the best BPH treatment in the future.
Who may be eligible?
This study is looking for men aged 50 or over who are having ongoing problems with their bladder and peeing due to an enlarged prostate (BPH), even after trying other non-surgical treatments. Your prostate would need to be considered quite large (at least 80ml).
You wouldn't be able to join if you've already had surgery for BPH, have or have had prostate cancer, or if your prostate isn't big enough for this study. Conditions like blockages in the urethra (the tube you pee through) or certain bladder conditions would also mean you couldn't take part. It's also important that you don't have an active urine infection, as this would need to be treated first.
Finally, you need to be able to understand what the study involves and be able to give your clear agreement to take part. Unfortunately, if you can't speak English well enough to understand and agree, you wouldn't be able to join.
Could this study suit you?
Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.
- Are you a man aged 50 or older?
- Are you having ongoing trouble with your bladder and peeing due to an enlarged prostate, even after trying other treatments?
- Has your doctor told you your prostate is quite large (80ml or more)?
- Have you *not* had previous surgery for your prostate?
- Do you *not* have prostate cancer?
- Do you understand basic information in English and can give your permission to join the study?
What does participation involve?
This section is not available in the provided text. Please refer to the full study protocol or speak to the research team for details on what taking part involves.
Potential risks and benefits
Locations (1)
- Thunder Bay Regional Health Sciences CentreVerified postcodeThunder Bay, Canada· Recruiting
Common questions
What is BPH?
BPH stands for Benign Prostatic Hyperplasia, which means a non-cancerous enlargement of the prostate gland in men.
What are the main symptoms of BPH?
Symptoms often include needing to pee more often, especially at night, a weak urine stream, or feeling like your bladder isn't completely empty.
Are these laser treatments new?
Both the Thulium Fibre Laser and Holmium MOSES laser are modern approaches, with TFL being a newer option that doctors are still learning more about.
Will I have a choice of which laser treatment I get?
This study is comparing the two treatments, so you would be assigned to one of them. Your study doctor can give you more details.
What's the main goal of this study?
The study aims to find out if one laser treatment leads to a shorter hospital stay or has better results during and after the operation compared to the other.
How to find out more
Rabail Siddiqui, MPH, MHSc
Always speak to your GP or specialist before deciding to take part in a study.
Interested in taking part?
Discussion
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