RecruitingNAINTERVENTIONAL

Xenografts Development From Surgical Tumor Samples of Patients With Triple Negative or Luminal B Breast Cancer

This study is looking at breast cancer cells taken from patients during surgery. The goal is to grow these human cancer cells in mice, creating what scientists call 'patient-derived xenografts' (PDX). These 'xenografts' act like a living model of a person's tumour. Researchers are particularly interested in Triple Negative and Luminal B breast cancers, especially those that haven't spread. By studying these models, they hope to learn more about how these cancers develop, why they sometimes become resistant to treatment, and how different parts of a tumour respond to therapies. This understanding could lead to more effective and targeted treatments for future patients with these types of breast cancer.

At a glance

Status

Recruiting

Phase

Sponsor

Centre Jean Perrin

Enrolment target

Start

19 Nov 2021

Estimated completion

31 Aug 2030

Breast Cancer Female

What is this study about?

This study is working to grow breast cancer cells taken during surgery from patients. These cells are then grown in special mice to create what researchers call 'patient-derived xenografts' or PDX models. Think of it like making a living copy of a patient's tumour, but in a mouse. This allows scientists to study the cancer in a way that is very similar to how it behaves in a person, without putting the patient at risk.

Most often, these types of models have been made from cancers that have already spread. However, this study focuses on breast cancer samples taken earlier, either from the main tumour before it spreads, or after a patient has had some initial treatment. By doing this, researchers hope to get a much clearer picture of how these cancers change over time and why treatments sometimes stop working. They want to understand the differences within a tumour and how these differences affect its response to medicines.

The main goal is to successfully create these PDX models from different types of breast cancer, specifically Triple Negative and Luminal B. By comparing the original tumour to the grown model, they can see if the model accurately reflects the patient's cancer. This research is important because it could lead to much-needed breakthroughs in understanding and treating these complex forms of breast cancer, potentially paving the way for more personalised and effective therapies in the future.

Key takeaways

Researchers are growing human breast cancer cells in mice to study them.
This study focuses on Triple Negative and Luminal B breast cancers.
No new treatments are given; samples are taken during routine surgery and blood draws.
The goal is to understand how these cancers develop and respond to treatment.
Findings could lead to improved treatments for future patients.
You can stop participating at any time without affecting your medical care.

Who may be eligible?

This study is for women who have been diagnosed with certain types of breast cancer, specifically Triple Negative or Luminal B breast cancer. You need to be 18 years old or older to participate.

To be considered, you must be well enough to carry out daily activities with little to no difficulty. You will also need to sign a consent form showing you understand and agree to take part, and be part of a social security scheme, which covers your healthcare in the UK.

There are specific requirements about the size of the tumour or remaining cancer after treatment, depending on your exact cancer type (such as metastatic, inflammatory, or metaplastic Triple Negative, or Luminal B). These measurements are taken from your surgical samples or scans. If your cancer has spread, you might still be able to join if part of the tumour can be surgically removed and is a certain size.

Could this study suit you?

Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.

Are you a woman aged 18 or older?
Do you have Triple Negative or Luminal B breast cancer?
Are you able to manage your daily activities without much difficulty?
Are you willing to provide blood samples for the study?
Do you have a tumor (or remaining tumor after treatment) of a certain size as measured by your doctors?

Answer every question to see your result.

What does participation involve?

Taking part in this study primarily involves the collection of blood samples at different times. The main focus of the study is on using the tumour tissue that is already being removed during your surgery. You won't be given any new medications specifically for this study. The study aims to follow your progress over time, likely through your routine medical check-ups and recorded information, but no specific extra visits are outlined beyond the blood collection. The total duration of your participation isn't specified in terms of extra appointments, but a long-term follow-up of your cancer's progression is implied.

Potential risks and benefits

A potential benefit of taking part is that your involvement contributes valuable tissue samples and information that could lead to a better understanding of breast cancer. This research may help develop more effective treatments for future patients with Triple Negative or Luminal B breast cancer. As no new treatments or medications are being given as part of this study, the direct physical risks to you are expected to be very low, primarily limited to the discomfort and small risk of bruising or infection from blood draws. You are free to withdraw from the study at any time, for any reason, without it affecting your medical care.

Locations (1)

Centre Jean PERRIN
Verified postcode
Clermont-Ferrand, France· Recruiting

Common questions

What is a 'xenograft'?

A xenograft is when a small piece of your tumour is taken and grown in a special mouse. It helps scientists study your cancer outside your body.

Will I receive any new treatment as part of this study?

No, this study does not involve giving you any new treatments or medications. It uses samples already taken during your medical care to understand cancer better.

What types of breast cancer are being studied?

This study is focusing on specific types of breast cancer called Triple Negative and Luminal B breast cancer.

Will taking part affect my medical care?

No, your decision to participate or not will not affect the medical care you receive for your breast cancer.

Why is this research important?

This research helps scientists learn more about how breast cancer grows and responds to treatment. This could lead to better ways to treat these cancers in the future.

How to find out more

Judith PASSILDAS, PhD

judith.passildas@clermont.unicancer.fr +33463663337 Official trial record

Always speak to your GP or specialist before deciding to take part in a study.