RecruitingOBSERVATIONAL

Genetic Predisposition to Breast and Ovarian Cancer: Prospective Study of BRCAx Gene Mutation

This study is for people who have inherited a faulty BRCA gene. Having a faulty BRCA gene means you have a higher chance of developing certain cancers, like breast and ovarian cancer. The researchers want to learn more about how these genetic changes affect people's health throughout their lives. By understanding this better, they hope to improve care and support for people with faulty BRCA genes in the future. Participants will be asked to fill out questionnaires to share information about their health journey.

At a glance

Status

Recruiting

Sponsor

Institut Paoli-Calmettes

Enrolment target

5,000

Start

15 Oct 1999

Estimated completion

15 Oct 2028

Breast Cancers Ovarian Cancers

What is this study about?

This study is called 'Genetic Predisposition to Breast and Ovarian Cancer: Prospective Study of BRCAx Gene Mutation.' That's a bit of a mouthful, but in simple terms, it means researchers are looking closely at how certain faulty genes, called BRCA genes, can make someone more likely to develop breast and ovarian cancers.

You might have heard of BRCA1 or BRCA2 genes. Everyone has BRCA genes, and they normally help protect us from cancer. But if there's a fault or 'mutation' in these genes, that protection isn't as strong, and the risk of developing certain cancers, especially breast and ovarian cancer, goes up. This study wants to follow a group of people who know they have one of these faulty BRCA genes.

The main goal is to understand more about these conditions over a long period. By collecting information from people with the faulty gene, the researchers hope to gain valuable insights into how these cancers develop, how people manage their health, and ultimately, how to offer better support and prevention strategies in the future. The information gathered could help doctors and scientists make important discoveries to benefit others.

Key takeaways

This study is for people with a known faulty BRCA gene.
It aims to understand more about breast and ovarian cancers linked to these genes.
Participation involves answering health questionnaires.
It is open to both men and women aged 18 and over, with or without cancer.
Your involvement helps improve future care for others with faulty BRCA genes.

Who may be eligible?

To join this study, you need to be at least 18 years old. This study is open to both men and women.

The most important requirement is that you must know you have a change (mutation) in your BRCA1 or BRCA2 gene. You can be someone who has had cancer, or someone who has never had cancer but knows they carry this faulty gene.

Also, you'll need to be able to give your clear agreement to take part and be part of a social security system in the UK. Unfortunately, if you have a legal guardian or find it difficult to follow up due to things like where you live, social situations, or mental health, you might not be able to join.

Could this study suit you?

Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.

I am 18 years old or older.
I have been told I have a faulty BRCA1 or BRCA2 gene.
I understand and can clearly agree to take part.
I am part of a UK social security system.
There are no major personal reasons (like location or social situation) that would stop me from completing questionnaires.

Answer every question to see your result.

What does participation involve?

If you decide to take part in this study, you won't need to take any new medications or have special medical procedures. Your involvement will mainly be through answering questionnaires. These questionnaires will ask about your health history and experiences related to having a faulty BRCA gene. The study will follow you over time to understand your health journey. The exact number of questionnaires or how long you'll be involved isn't specified, but the study aims to follow people over a period to collect long-term information.

Potential risks and benefits

Taking part in this study doesn't involve any physical medical treatments, so there are no direct physical risks. You might find some of the questions personal or feel a bit anxious discussing health topics. Any information you provide will be kept confidential. While there's no direct personal benefit to you from taking part, the information you share will be incredibly valuable to researchers, helping them understand more about faulty BRCA genes and potentially improving care for others in the future. Remember, you can choose to stop taking part in the study at any time, for any reason, without it affecting your medical care.

Locations (1)

Institut Paoli-Calmettes
Verified postcode
Marseille, France· Recruiting

Common questions

What is a BRCA gene mutation?

A BRCA gene mutation is a change in a gene that increases your risk of developing certain cancers, especially breast and ovarian cancer.

Do I need to live in a specific area to join?

You need to be able to follow up with the study, so if geographical reasons make that impossible, you might not be eligible.

Will I have to take new medicine?

No, this study only involves providing information through questionnaires, not taking any new medicine.

How long will I be in the study?

The study aims to follow participants over time, but the exact duration isn't specified.

What kind of questions will I be asked?

You will be asked health-related questions through questionnaires, typically about your health history and experiences.

How to find out more

Dominique GENRE, MD

drci.up@ipc.unicancer.fr 33 491 22 37 78 Official trial record

Always speak to your GP or specialist before deciding to take part in a study.