Modulation of THC Effects by CBD: a Dose-ranging Study
This study is investigating how different amounts of CBD might change the effects of THC, the main mind-altering part of the cannabis plant. Researchers want to see if CBD can make the 'high' experience different when THC and CBD are used together. They are looking at various combinations of CBD to THC to understand how these mixtures affect people's thinking, behaviour, and overall feelings. The goal is to provide clearer information for public safety, help people who use cannabis make more informed choices, and give regulators better guidance. This research will help us understand the short-term effects of using CBD and THC together by inhalation in people who occasionally use cannabis.
At a glance
What is this study about?
This study is all about understanding how two important parts of the cannabis plant, THC and CBD, work together. THC is the part that makes you feel 'high,' and CBD is another part that doesn't cause a high but is thought to have other effects. Many people are told to use cannabis products that also contain CBD, but we don't fully understand if or how CBD changes what THC does, especially when they are used together.
The main goal is to figure out if different amounts of CBD can change the 'high' or other mind-altering effects that THC causes. The researchers are looking at various combinations of CBD and THC. They also want to see if CBD changes other effects of THC on a person's behavior. Ultimately, this study aims to uncover how these compounds interact on a deeper level than we currently understand.
This research is important because, with more places legalising cannabis, it's crucial to have clear information for everyone. By learning more about how CBD and THC interact, we can help create better safety guidelines, empower individuals who use cannabis to make more informed choices about the products they buy, and guide future research. This will improve our understanding of the immediate effects when these two compounds are inhaled together by people who use cannabis occasionally.
Key takeaways
- This study explores how CBD changes the effects of THC.
- It aims to understand different CBD:THC ratios.
- The research will help develop safer cannabis use guidelines.
- Participants will inhale THC and CBD combinations.
- The study focuses on occasional cannabis users.
- It's about contributing to general knowledge, not personal treatment.
Who may be eligible?
To join this study, you need to be aged between 21 and 49 years old. You must have used cannabis at some point in your life, but not too often recently – specifically, three days or less in the month before you enroll. You also need to be able to fully understand the study details and agree to take part by signing a consent form.
There are also some health checks. Your lung function will be checked, and you must be able to speak and understand English or French. For women, it's important that you are either past menopause, have had certain surgeries that prevent pregnancy, or if you can become pregnant, you must have a negative pregnancy test and agree to use reliable birth control throughout the study, with no plans to get pregnant.
You would not be able to join if you have any serious health problems that might make taking part unsafe, as judged by the study doctor. This includes certain severe mental health conditions like schizophrenia or bipolar disorder, or ongoing severe depression. You also can't have serious liver or kidney problems, or high blood pressure above a certain level.
Could this study suit you?
Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.
- Are you between 21 and 49 years old?
- Have you used cannabis before but not more than 3 days in the last month?
- Are you able to speak and understand English or French?
- For women who could become pregnant: are you willing to use reliable birth control and don't plan to get pregnant during the study?
- Do you have good overall health, without serious heart, lung, kidney, or mental health issues?
What does participation involve?
If you join this study, you'll be one of the participants who occasionally uses cannabis. The study involves coming to the research centre for several visits. During these visits, you will inhale different combinations of THC and CBD. These combinations will vary, so you will receive different ratios of CBD to THC, as well as a control product with no CBD.
At each visit, researchers will assess how the different combinations affect your thoughts, feelings, and behaviour. They will also look at some physical measures. You'll need to follow specific instructions throughout the study. The total duration of your involvement will depend on the study's schedule, but it will involve multiple visits to complete all the tests and receive the different interventions.
Potential risks and benefits
Locations (1)
- Centre de recherche du Centre Hospitalier Universitaire de MontréalVerified postcodeMontreal, Canada· Recruiting
Common questions
What is the main purpose of this study?
To see how different amounts of CBD affect the mind-altering effects of THC when they are used together.
Who can participate in this study?
People aged 21-49 who have used cannabis occasionally in the past.
Will I be given cannabis in this study?
You will inhale measured amounts of THC and CBD, separately and in combination, as part of the study.
Are there any health conditions that would stop me from joining?
Yes, serious heart, lung, liver, kidney, or certain mental health conditions would prevent you from taking part.
What happens if I change my mind about participating?
You are free to leave the study at any time, for any reason, without it affecting your medical care.
How to find out more
Pamela Lachance, PhD
Always speak to your GP or specialist before deciding to take part in a study.
Interested in taking part?
Discussion
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