RecruitingNAINTERVENTIONAL

Clareon PanOptix Versus AcrySof PanOptix : Prospective Study Comparing Contrast Sensitivity

This research is looking at two different artificial lenses (called intraocular lenses or IOLs) that are used during cataract surgery: the Clareon PanOptix and the AcrySof PanOptix. Both lenses are designed to help people see clearly after cataract removal and correct presbyopia (age-related difficulty focusing up close). The main goal of the study is to find out if the Clareon PanOptix lens helps people see contrasts (like black text on a grey background) better than the AcrySof PanOptix lens, three months after the operation. This study is for people having cataract surgery who also want their close-up vision corrected. Your doctor will place an AcrySof lens in one eye and a Clareon lens in the other to compare them.

At a glance

Status

Recruiting

Phase

Sponsor

Assistance Publique - Hôpitaux de Paris

Enrolment target

Start

01 Oct 2025

Estimated completion

15 Oct 2026

Cataract and IOL Surgery

What is this study about?

When you have cataract surgery, the cloudy lens in your eye is removed and replaced with a clear artificial lens, called an intraocular lens (IOL). Some IOLs, like those in this study, are designed to not only correct cataracts but also to help you see clearly at different distances, including close-up. This is often called presbyopia correction.

This study is comparing two specific types of these advanced IOLs: the Clareon PanOptix and the AcrySof PanOptix. Both are made by the same company, Alcon, and are widely used. Researchers want to understand if one of these lenses performs better than the other, particularly when it comes to *contrast sensitivity*. Contrast sensitivity is really important for everyday tasks, like driving at night or reading in dim light, as it helps you tell the difference between objects and their backgrounds.

The study involves people who are already planning to have cataract surgery and want to improve their close-up vision too. If you join, the surgeons would place one type of lens in one of your eyes and the other type of lens in your other eye during two separate operations. They will then carefully check your vision after the surgery to see which lens provides the best contrast vision. This kind of research helps doctors decide which lenses might be best for their patients in the future.

Key takeaways

Compares two artificial lenses (Clareon PanOptix and AcrySof PanOptix) for cataract surgery.
Aims to see if one lens gives better 'contrast vision' after surgery.
You would receive one type of lens in each eye during your cataract operations.
Main study tests happen at the 3-month follow-up appointment.
Helps improve future choices for cataract patients wanting multifocal lenses.

Who may be eligible?

To take part in this study, you need to be at least 18 years old and planning to have cataract surgery. You should also be interested in getting an artificial lens that helps you see clearly at different distances, including up close. Your cataracts should be of a certain type (grade 2 or 3), and your vision in both eyes should be quite similar before the surgery.

There are also some reasons why you wouldn't be able to join. For instance, if you are pregnant or breastfeeding, or if you have certain other eye conditions like glaucoma, severe dry eye, or a history of previous eye surgeries. People with certain severe eye problems that could affect the results or make the surgery more complicated would not be suitable.

This study is designed for people who are generally healthy, apart from their cataracts, and do not have other eye problems that could interfere with the lens's performance or the study's measurements. Your eye doctor will be able to tell you if you meet all the requirements.

Could this study suit you?

Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.

Are you 18 years old or older?
Are you having cataract surgery and want to correct your close-up vision too?
Do you have a certain type of cataract (grade 2 or 3) and similar vision in both eyes?
Are you NOT pregnant or breastfeeding, or planning to be soon?
Do you NOT have other serious eye conditions like glaucoma, severe dry eye, or previous eye surgery?

Answer every question to see your result.

What does participation involve?

If you decide to take part, your participation will mainly involve your routine cataract surgery and follow-up appointments. You won't have any extra examinations before or shortly after your operation beyond what's usually done. You will have two operations: one for each eye, where a different type of lens will be put into each eye. Your medical team will decide which lens goes into which eye.

Your first follow-up visits, around 3-10 days and then at 1 month after surgery, will be standard check-ups. The main part of the study happens during an extra visit around 3 months after your surgery. At this 3-month visit, in addition to your usual eye check, you will have specific tests to measure your contrast vision and another non-invasive eye scan called an "aberrometry test" (using an iTrace machine). These extra tests are quick and painless. The total duration of your active involvement in the study will be about three months.

Potential risks and benefits

Participating in this study might offer the benefit of receiving an advanced artificial lens that aims to improve your vision at various distances after cataract surgery. The main benefit to the wider community is helping doctors understand which of these lenses performs better. As with any surgery, there are general risks associated with cataract surgery itself, and specific risks linked to a specific type of artificial lens are generally low, but your surgeon will discuss these with you. You have the right to withdraw from the study at any time without affecting your medical care.

Locations (1)

Assistance Publique - Hôpitaux de Paris, Ophtalomopôle - Hôpital COCHIN
Verified postcode
Paris, France· Recruiting

Common questions

What is a cataract?

A cataract is when the clear lens inside your eye becomes cloudy, making your vision blurry or hazy, like looking through a foggy window.

What does 'IOL' mean?

IOL stands for Intraocular Lens. It's the artificial, clear lens that replaces your natural lens during cataract surgery.

What is contrast sensitivity?

Contrast sensitivity is your ability to see differences between objects and their backgrounds, especially in dim light or when colours are similar. It's important for daily tasks like reading or driving.

Will I get both types of lenses?

Yes, if you join this study, one type of lens (Clareon PanOptix) will be put into one of your eyes, and the other type (AcrySof PanOptix) into your other eye.

Are there any extra appointments if I join?

You will have a couple of extra tests during your 3-month follow-up visit, specifically to measure your contrast vision and to perform a special eye scan, but other visits are standard.

How to find out more

Dominique MONNET, MD, PhD

dominique.monnet@aphp.fr 01 58 41 22 01 Official trial record

Always speak to your GP or specialist before deciding to take part in a study.