RecruitingOBSERVATIONAL

Prospective Study on Antimicrobial RESIstance in Chronic Pulmonary DiseasE

This international study aims to understand more about 'antibiotic resistance' in people living with long-term lung conditions. Antibiotic resistance happens when germs learn to fight off the medicines meant to kill them, making infections harder to treat. The study will look at how common this resistance is in different places around the world and try to identify factors that make people with chronic lung diseases more likely to develop it. We'll also see which types of resistant germs are most often found. The information gathered will help doctors make better decisions about treating lung infections and developing new strategies to tackle antibiotic resistance globally.

At a glance

Status

Recruiting

Sponsor

Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico

Enrolment target

683

Start

31 Mar 2025

Estimated completion

01 Nov 2029

Chronic Lung Diseases

What is this study about?

Imagine antibiotics as a team of superheroes fighting off bad germs. Sometimes, these germs learn tricks to defeat the superheroes, making the antibiotics less effective. This is called 'antibiotic resistance'. It's a growing problem that makes infections much harder to treat.

This study is looking specifically at antibiotic resistance in people who have long-term lung conditions, such as COPD or asthma. These conditions can sometimes make people more prone to lung infections. Researchers around the world will collect information to understand how common antibiotic resistance is in these patients, where it's happening most often, and what might put someone at higher risk of getting a resistant infection. They also want to identify the types of resistant germs that are most frequently seen.

This is an 'observational' study, which means doctors will simply record information from patients as part of their routine care. There are no new treatments or tests involved. By gathering this detailed information from many different hospitals and clinics, the aim is to get a clearer picture of the problem globally. This knowledge is vital for helping doctors choose the right antibiotics, developing new medicines, and ultimately improving care for people with chronic lung conditions.

Key takeaways

This study looks at antibiotic resistance in people with long-term lung conditions.
It aims to understand how common it is, where it happens, and why.
No new tests, medicines, or procedures are involved for patients.
Information is collected from routine medical records and some questions.
Your personal details will be kept private and anonymised.
The goal is to improve treatment for lung infections in the future.

Who may be eligible?

To be part of this study, you need to have a long-term lung condition, such as asthma or COPD. Also, within the last year, your doctor should have taken a sample from your airways – this could be something like a spit (sputum) sample, a swab from your nose or throat, or a sample taken during a lung procedure like a bronchoalveolar lavage.

You would be included whether you are visiting an outpatient clinic (like a regular check-up at the hospital) or if you are staying in hospital during the time when the study information is being collected.

However, you can't join the study if you haven't given your permission by signing a consent form. Also, if there isn't enough information in your medical records for the study, you wouldn't be able to take part.

Could this study suit you?

Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.

Do you have a long-term lung condition?
Have you had a respiratory sample (like a spit test, nasal/throat swab, or lung fluid sample) taken by a doctor in the last 12 months?
Are you able to sign a consent form?
Are you currently seeing doctors in a hospital outpatient clinic or are you hospitalised?

Answer every question to see your result.

What does participation involve?

If you take part in this study, you won't need any extra visits, tests, or treatments. Doctors will simply collect information from your medical notes during your usual hospital appointments or stays. This information includes details about your health, your lung condition, and any germ samples (like spit samples) that have been taken as part of your normal care in the past 12 months. They will also ask you some questions about your health and background. This information will be collected during two separate two-week periods each year, over five years. All the procedures fall within standard NHS care, so nothing extra is done specifically for the study.

Potential risks and benefits

Because this study only collects information from your existing medical records and routine care, there are no physical risks involved for you. You won't have any extra procedures, tests, or medications. The main benefit is that the information gathered will help doctors and researchers worldwide better understand antibiotic resistance in long-term lung conditions. This knowledge could lead to improved treatments and care for people like you in the future. You have the right to withdraw from the study at any time, meaning your information would no longer be used, and this would not affect your care in any way.

Locations (68)

University of Michigan
Verified postcode
Ann Arbor, United States· Recruiting
Catholic University Our Lady of Good Counsel
Verified postcode
Tirana, Albania· Recruiting
Frankston Hospital
Verified postcode
Frankston, Australia· Recruiting
Antwerp University Hospital
Verified postcode
Antwerp, Belgium· Recruiting
CHU St Pierre
Verified postcode
Brussels, Belgium· Recruiting
AZ Maria Middelares
Verified postcode
Ghent, Belgium· Recruiting
Ghent University Hospital
Verified postcode
Ghent, Belgium· Recruiting
University Hospital Leuven
Verified postcode
Leuven, Belgium· Recruiting
Santa Casa de Belo Horizonte
Verified postcode
Minas Gerais, Brazil· Recruiting
Foothills Medical Centre
Verified postcode
Calgary, Canada· Recruiting
Hangzhou Red Cross Hospital
Verified postcode
Hangzhou, China· Recruiting
Dubrava University Hospital
Verified postcode
Zagreb, Croatia· Recruiting

Common questions

What is 'antibiotic resistance'?

It's when germs learn to fight off antibiotics, making infections harder to treat effectively.

Will I have to take any new medicines or have extra tests?

No, this study only collects information from your usual medical care. Nothing extra will be done.

What kind of information will be collected about me?

Doctors will gather details about your lung condition, general health, and results from any routine germ samples you've had.

Is my personal information kept private?

Yes, all your information will be anonymised (names and identifying details removed) before it's used in the study.

Can I decide not to be part of the study later?

Yes, you can withdraw your consent at any time without it affecting your medical care.

How to find out more

Andrea Gramegna

andrea.gramegna@unimi.it 0255032020 Official trial record

Always speak to your GP or specialist before deciding to take part in a study.