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Active not recruitingOBSERVATIONAL

French Observational Study of Patients With Chronic Lymphocytic Leukemia Or Small Lymphocytic Lymphoma in Real-World Settings

This French study is observing how chronic lymphocytic leukaemia (CLL) and small lymphocytic lymphoma (SLL) are managed in everyday healthcare settings. CLL is a common type of leukaemia, and SLL is similar but typically doesn't show high numbers of cancer cells in the blood. Over the last ten years, treatments for these conditions have advanced a lot, with new medications now available in addition to older ones. Researchers want to understand which treatments are being used, how they affect patients in the long term, and how decisions are made about care. This will help them learn more about the best ways to treat CLL and SLL and improve outcomes for people living with these conditions in the future.

At a glance

Status
Active not recruiting
Sponsor
French Innovative Leukemia Organisation
Enrolment target
1,000
Start
11 Nov 2022
Estimated completion
01 Dec 2032

What is this study about?

You might be reading this because you or someone you know has been diagnosed with chronic lymphocytic leukaemia (CLL) or small lymphocytic lymphoma (SLL). These are types of cancer that affect white blood cells called lymphocytes. CLL is the most common form of leukaemia in Western countries, and SLL is very similar.

Over the past ten years, there have been many new developments in how CLL and SLL are treated. Doctors now have more options, including different types of chemotherapy, as well as newer, more targeted medicines. This study wants to understand how these new treatments are being used in everyday medical practice across France. They are not testing a new drug, but rather looking at what is already happening in hospitals and clinics.

The main goal is to see how different treatment choices affect patients in the long run. By collecting information from many patients, researchers hope to get a clearer picture of which treatments lead to the best results and how various factors influence a patient's journey. This knowledge is important because it can help improve future care and guide doctors in making the best treatment decisions for each patient.

Key takeaways

  • This study observes real-life care for CLL and SLL in France.
  • It aims to understand how existing treatments affect patients long-term.
  • Participation doesn't change your medical treatment; you continue with standard care.
  • Researchers hope to improve future treatment guidelines and patient outcomes.
  • Your information helps doctors learn more about these conditions.

Who may be eligible?

To be part of this study, you need to be at least 18 years old and have a diagnosis of CLL or SLL. Crucially, your doctors must have decided that you currently need treatment for your condition, or for related immune problems like low blood platelets or anaemia caused by your immune system.

This study includes people who are starting treatment for the first time, as well as those who have had treatment before. Even if you're already in another clinical trial, you might still be able to join this observational study. The most important thing is that your medical team has agreed that you need treatment for your CLL or SLL.

However, you can't join if you don't need treatment for your CLL/SLL at this time, or if your condition is a very early, asymptomatic stage. You also can't take part if you have a more aggressive type of lymphoma called Richter's syndrome, or if your only current need is for immunoglobulin infusions without needing more specific CLL/SLL therapy.

Could this study suit you?

Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.

  1. Are you 18 years old or over?
  2. Have you been diagnosed with CLL or SLL?
  3. Has your doctor decided that you need treatment for your CLL/SLL now?
  4. Are you able to agree to your medical data being used for research?
Answer every question to see your result.

What does participation involve?

This is an observational study, which means you won't be given a new or experimental treatment. Instead, your doctors will continue to manage your CLL or SLL as they normally would, based on what they believe is best for you. The study will simply collect information about the treatment you receive, how you respond to it, and how you are doing over time. This includes details from your regular doctor's appointments, blood test results, and any new genetic tests performed. Your medical team will continue to make all decisions about your care. The total duration of your participation will depend on how long you receive treatment and are followed up by your medical team, as the study aims to look at long-term outcomes.

Potential risks and benefits

Participating in this study involves very low risk as it doesn't change your medical care; you will receive the same treatment you would have otherwise. The main benefit is that your information will contribute to a better understanding of CLL and SLL, potentially leading to improved care for others in the future. You have the right to withdraw your consent for your data to be used at any time without affecting your medical treatment.

Locations (57)

  • AMIENS - CH Amiens Picardie Site Sud
    Verified postcode
    Amiens, France
  • Angers Chu
    Verified postcode
    Angers, France
  • ANNECY - CH Annecy Genevois
    Verified postcode
    Annecy, France
  • ARGENTEUIL - Centre hospitalier Victor Dupouy
    Verified postcode
    Argenteuil, France
  • AVIGNON - Centre Hospitalier
    Verified postcode
    Avignon, France
  • BESANCON - Hôpital Jean Minjoz
    Verified postcode
    Besançon, France
  • BEZIERS - Centre Hospitalier - Hématologie
    Verified postcode
    Béziers, France
  • BLOIS CH
    Verified postcode
    Blois, France
  • APHP - Hôpital Avicenne
    Verified postcode
    Bobigny, France
  • APHP - Hôpital Jean Verdier
    Verified postcode
    Bondy, France
  • BOURGOUIN-JALLIEU - CH Pierre Oudot
    Verified postcode
    Bourgoin, France
  • BREST - Hôpital Morvan - Hématologie Clinique
    Verified postcode
    Brest, France

Common questions

What is the difference between CLL and SLL?

CLL and SLL are very similar blood cancers. CLL usually means there are high numbers of cancer cells in the blood, while SLL means the cancer cells are mainly found in lymph nodes or other tissues, without a high number in the blood.

Will I receive new medicine in this study?

No, this is an observational study. You will receive the standard treatments that your doctors believe are best for you. The study is simply collecting information about those treatments.

Who is running this study?

This is a French study, looking at real-world treatment of CLL and SLL across hospitals and clinics in France.

How long will I be involved in the study?

The study aims to look at long-term outcomes, so your participation would continue as long as you are receiving treatment and being regularly followed up for your CLL/SLL.

What happens to my personal information?

Your data will be processed electronically for this study. The researchers will take great care to protect your privacy and ensure your information is kept confidential.

How to find out more

Always speak to your GP or specialist before deciding to take part in a study.

Discussion

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