RecruitingNAINTERVENTIONAL

Efficacy of CAD in Screening Colonoscopy to Reduce the Risk of Advanced Adenoma at 3 Years.

We are looking into whether a special computer program, called CAD, can help doctors find small growths (polyps) in your bowel during a colonoscopy more effectively. Sometimes, polyps can be missed, leading to problems later. This study aims to see if using CAD helps spot these polyps better, potentially reducing your risk of developing more serious growths or bowel cancer over three years. Participants will have a colonoscopy either with or without this computer help. After three years, we'll check back to see how effective the computer aid was in preventing advanced growths.

At a glance

Status

Recruiting

Phase

Sponsor

University Hospital, Bordeaux

Enrolment target

592

Start

13 Mar 2026

Estimated completion

01 Mar 2031

Colonoscopy Colorectal Neoplasms Intestinal Polyps

What is this study about?

This research is designed to investigate if using a special computer program during a colonoscopy can improve how well doctors find small growths in your bowel. These growths, called polyps, are usually harmless, but some can turn into cancer over time if not removed. Even with a colonoscopy, sometimes tiny polyps can be missed. We call these 'missed lesions', and they can sometimes lead to issues later on.

The computer program, known as CADe (Computer-Aided Detection), acts like an extra pair of eyes for the doctor. It's designed to highlight areas that might be polyps, helping the doctor to see them more clearly. The main goal of this study is to find out if using this computer help means fewer advanced polyps develop in patients over a three-year period, potentially reducing the risk of bowel cancer.

We want to see if this new technology can make colonoscopies even better at preventing bowel cancer. By carefully comparing colonoscopies done with and without the CADe system, we hope to understand its long-term benefits.

Key takeaways

This study investigates if computer help (CADe) improves polyp detection during colonoscopies.
It aims to reduce the risk of advanced growths or bowel cancer over three years.
Participants will have a standard colonoscopy or one with CADe.
A follow-up will occur at one month and then three years after the initial procedure.
Your decision to participate is voluntary, and you can withdraw at any time.

Who may be eligible?

To join this study, you need to be at least 18 years old. You might be asked to take part if you are having a colonoscopy because: a recent stool test showed something unusual (this is called a positive FIT test), you or your family have a history of bowel cancer, or you've had polyps in your bowel before.

There are some reasons why you might not be able to join. For example, if you haven't had a proper bowel preparation before your colonoscopy, or if the doctor can't complete the procedure fully. Also, if you're pregnant, have certain serious bowel conditions, or have had bowel surgery in the past, you might not be eligible.

Before you can join, you'll also need to sign a consent form, which explains everything about the study in detail, and have health insurance. Don't worry if you're not sure, the study team will go through everything with you.

Could this study suit you?

Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.

Are you at least 18 years old?
Are you having a colonoscopy for screening, a positive stool test, or a history of bowel issues?
Are you able to sign a consent form?
Are you NOT pregnant?
Do you NOT have serious inflammatory bowel disease or a history of bowel surgery?

Answer every question to see your result.

What does participation involve?

If you decide to join this study, you'll first have a chat with a doctor to check if it's right for you. Then, you'll have your colonoscopy as planned. In the endoscopy room, you'll be randomly assigned to one of two groups: one group will have a standard colonoscopy, and the other will have their colonoscopy with the special computer help (CADe).

About a month after your colonoscopy, you'll have a follow-up appointment to get your results. After this, we'll keep in touch. If you're in a group that's considered to have a higher risk of bowel cancer, you'll be asked to come back for another colonoscopy in three years. This follow-up colonoscopy will use the CADe system for everyone in this group, and another doctor who doesn't know about your first colonoscopy will perform it. If you're in the lower-risk group, we will simply collect information about any future colonoscopies you might have as part of your usual care. The total duration of your active involvement in the study will be three years.

Potential risks and benefits

Taking part in this study may offer the benefit of potentially detecting polyps more thoroughly during your colonoscopy, thanks to the advanced computer system, which could reduce your risk of developing more serious conditions later on. As with any medical procedure, there are always potential risks; however, a colonoscopy is a routine and generally safe procedure. You have the right to withdraw from the study at any time without giving a reason, and this will not affect your medical care.

Locations (13)

CH de la Côte Basque
Verified postcode
Bayonne, France· Not yet recruiting
CHU Brest la Cavale Blanche
Verified postcode
Brest, France· Not yet recruiting
Clinique Paris Bercy
Verified postcode
Charenton-le-Pont, France· Not yet recruiting
CHU de Limoges
Verified postcode
Limoges, France· Not yet recruiting
Institut Paoli Calmettes
Verified postcode
Marseille, France· Not yet recruiting
Clinique Jules Verne
Verified postcode
Nantes, France· Not yet recruiting
CHU Nîmes
Verified postcode
Nîmes, France· Not yet recruiting
APHP - Hôpital Saint Antoine
Verified postcode
Paris, France· Not yet recruiting
Aphp-Hegp
Verified postcode
Paris, France· Not yet recruiting
CHU Bordeaux - Hôpital Haut Lévêque
Verified postcode
Pessac, France· Recruiting
CHU de Rennes
Verified postcode
Rennes, France· Not yet recruiting
Clinique Pasteur
Verified postcode
Toulouse, France· Not yet recruiting

Common questions

What is CADe?

CADe is a special computer program that helps doctors spot growths (polyps) in your bowel more easily during a colonoscopy.

Will I know if I'm getting the computer help or not?

You won't know at the time of the procedure because you'll be randomly assigned to one of the groups, like flipping a coin for fairness.

What happens after my colonoscopy?

You'll have a follow-up appointment about a month later for your results, and then we'll check in with you again in three years.

Will I have to have another colonoscopy?

Only if you're in a group considered at higher risk of bowel cancer, you'll be scheduled for another colonoscopy in three years for the study.

Can I stop being part of the study once I've started?

Yes, you can choose to leave the study at any time, and it won't affect your medical treatment.

How to find out more

Arthur BERGER, MD

arthur.berger@chu-bordeaux.fr +335 57 67 49 31 Official trial record

Always speak to your GP or specialist before deciding to take part in a study.