RecruitingInterventional

Mentalization-based therapy for individuals with probable complex post-traumatic stress disorder

This study is exploring a new type of therapy called Mentalization-Based Treatment - Trauma Focused (MT-TF) for adults living with Complex Post-Traumatic Stress Disorder (CPTSD). CPTSD can cause long-lasting distress and difficulties, and effective treatments are much needed. The study aims to find out if MT-TF is more helpful than the treatment usually offered. MT-TF focuses on helping people understand their thoughts and feelings, especially those related to past traumatic experiences. Researchers hope this study will offer a better way to support people with CPTSD, reduce their symptoms, and improve their daily lives.

At a glance

Status

Recruiting

Sponsor

Noclor

Enrolment target

198

Start

01 Jun 2025

Estimated completion

01 Aug 2026

Complex post-traumatic stress disorder (CPTSD)

What is this study about?

This research is looking at a new type of therapy called Mentalization-Based Treatment - Trauma Focused (MT-TF). We know that Complex Post-Traumatic Stress Disorder (CPTSD) can be very tough for people, affecting their mood, relationships, and even their physical health. It can also lead to other mental health problems and, in some cases, increase the risk of suicide. Currently, there aren't many treatments that effectively deal with both the trauma and the other difficulties that often come with CPTSD.

The aim of MT-TF is to specifically help people cope with the effects of trauma in a way that is designed to be supportive and understanding. The therapy tries to help people understand their own thoughts and feelings, and those of others, especially when these thoughts and feelings are linked to difficult past experiences. The goal is to reduce distress and help people manage their symptoms better, while also making sure they feel comfortable and supported throughout their treatment journey.

This study will compare MT-TF with the usual care people receive (called 'Treatment as Usual' or TAU) to see which one works better for adults diagnosed with CPTSD who are already getting help from personality disorder services. The results could lead to better ways to help people with CPTSD in the future.

Key takeaways

The study explores a new therapy (MT-TF) for Complex Post-Traumatic Stress Disorder (CPTSD).
It compares MT-TF with standard treatment to see which is more effective.
Participation involves group therapy sessions over 9 months and follow-up assessments.
The study aims to improve understanding and treatment options for CPTSD.
You can withdraw from the study at any time without affecting your care.

Who may be eligible?

To join this study, you need to be an adult between 18 and 65 years old. You also need to have been diagnosed with Complex Post-Traumatic Stress Disorder (CPTSD), and be able to speak and understand English well enough to take part in the therapy and assessments.

There are a few reasons why someone might not be able to join. For example, if you are currently experiencing a severe mental health episode involving losing touch with reality (doctors call this a psychotic episode), or if you have a serious neurological condition affecting your brain or nervous system, you wouldn't be able to participate.

The research team will carry out a thorough check to make sure the study is right for you and that you meet all the necessary requirements to ensure your safety and the success of the study.

Could this study suit you?

Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.

Are you between 18 and 65 years old?
Have you been diagnosed with or suspected of having Complex Post-Traumatic Stress Disorder (CPTSD)?
Do you speak and understand English well enough to take part in therapy and discussions?
Are you currently not experiencing a severe mental health episode (like psychosis)?
Do you not have a severe neurological condition?

Answer every question to see your result.

What does participation involve?

If you decide to take part, you'll first have some assessments to make sure the study is suitable for you. Then, you'll be randomly assigned to one of two groups, like flipping a coin, to receive either the new MT-TF therapy or the treatment that’s usually given (Treatment as Usual).

If you're in the MT-TF group, you'll attend weekly group therapy sessions, each lasting 90 minutes. You can expect to have about 36 group sessions over nine months, and up to 5 individual supportive therapy sessions if you need them. Even if you're in the 'Treatment as Usual' group, you'll still be part of the study's follow-up.

Throughout the study, regardless of your treatment group, you'll have follow-up assessments at 3, 9, and 15 months after starting. These involve interviews and questionnaires to see how you're feeling and how the treatment is working. While these appointments can take some time, the researchers will make sure you have regular breaks if needed.

Potential risks and benefits

Participating in this study comes with very low risk. Both the new therapy (MT-TF) and the usual care will be provided by experienced professionals who regularly work with people facing similar challenges. You will receive a treatment that you might not otherwise have access to, and your participation could help improve future treatments for others with CPTSD. The assessments, while time-consuming, do not carry specific risks; researchers are highly trained and can offer breaks if you feel overwhelmed. Remember, you can choose to withdraw from the study at any time, for any reason, without it affecting your usual medical care.

Locations (9)

Some site locations are approximate. We're improving this — please verify with the trial team before travelling.

Oxleas NHS Foundation Trust
City only
Dartford, United Kingdom
Merseycare NHS Trust
City only
Prescot, United Kingdom
Kent and Medway NHS and Social Care Partnership Trust
City only
Maidstone, United Kingdom
Greater Manchester Mental Health NHS Foundation Trust
City only
Manchester, United Kingdom
South London and Maudsley NHS Foundation Trust
City only
Beckenham, United Kingdom
Avon and Wiltshire Mental Health Partnership NHS Trust
Unverified
Bath, United Kingdom
Devon Partnership NHS Trust
Unverified
Exeter, United Kingdom
South West London and St. George's Mental Health NHS trust
Unverified
London, United Kingdom
Barnet, Enfield and Haringey Mental Health NHS Trust
Unverified
London, United Kingdom

Common questions

What is CPTSD?

CPTSD, or Complex Post-Traumatic Stress Disorder, is a condition that can develop after repeated or long-lasting trauma, often in childhood. It can cause difficulties with emotions, relationships, and how you see yourself.

What is 'Mentalization-Based Treatment - Trauma Focused'?

It's a type of talking therapy that helps you understand your own and others' thoughts and feelings, especially those linked to your past traumatic experiences. The goal is to better manage your emotions and relationships.

How long will the study last if I take part?

The main treatment period is about 9 months, but you'll have follow-up assessments for up to 15 months after you start the study.

Will I get paid for taking part?

The study information doesn't mention payment for participation, but your travel expenses may be covered. You can ask the study team about this.

Who is running this study?

The study is being sponsored by the North London NHS Foundation Trust and led by University College London (UCL).

How to find out more

Elizabeth Simes

e.simes@ucl.ac.uk +44 (0)2076792000 Official trial record

Always speak to your GP or specialist before deciding to take part in a study.