PET study of changes in [11C]AZ14132516 uptake following administration of AZD7798 to healthy participants and patients with Crohn’s disease
This research study is looking into a new medicine called AZD7798, which could potentially help people with Crohn's disease. We want to understand how it affects the body. To do this, we'll use a special type of scan called a PET scan. This scan uses a very small, safe amount of a substance called [11C]AZ14132516 to show us what's happening inside. We'll be giving the new medicine to both healthy people and individuals who have Crohn's disease. By comparing the scan results before and after taking the medicine, we hope to learn more about how AZD7798 works in the body and if it could be a helpful treatment option in the future. This is an early stage study, focusing on understanding the medicine better.
At a glance
What is this study about?
This study is an early stage of research, sometimes called a Phase 1 study. The main goal at this stage isn't to find a cure, but to learn more about a new medicine called AZD7798. We want to see how it behaves in the body and if it's safe. Think of it like testing a new recipe – first, you want to make sure the ingredients are safe to eat before you try to make a whole meal.
We'll be using a special type of body scan, called a PET scan, before and after people take the medicine. This scan helps doctors see tiny changes inside the body without surgery. It uses a very small amount of a tracing substance, which is completely safe and clears from your body quickly. By looking closely at how this tracing substance changes with the medicine, we hope to understand exactly how AZD7798 might work against Crohn's disease.
Taking part in this study helps doctors gather important information. This knowledge is crucial for developing new and better treatments for Crohn's disease in the future. Even though this specific study won't provide direct treatment for your Crohn's, your involvement could pave the way for new medicines that help many others.
Key takeaways
- This is an early study of a new medicine for Crohn's disease.
- It uses special scans to see how the medicine works inside the body.
- Both healthy volunteers and people with Crohn's disease can join.
- Your participation helps doctors learn to develop future treatments.
- You won't necessarily get direct treatment for your Crohn's from this study.
- You can stop taking part at any time.
Who may be eligible?
This study is open to adults who are at least 18 years old, both men and women. We're looking for two main groups of people to take part.
One group will be healthy volunteers. These are people who don't have Crohn's disease or other major health problems. Their involvement helps us understand how the new medicine works in a typical body.
We are also looking for a second group of people who have been diagnosed with Crohn's disease. There will likely be specific requirements for people with Crohn's, such as how active their condition is or what medicines they are currently taking. The study team will check if you meet all the necessary health criteria to make sure it's safe for you to participate.
Could this study suit you?
Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.
- Are you 18 years old or older?
- Are you a man or a woman?
- Do you have Crohn's disease, or are you generally healthy?
- Are you prepared to attend several clinic visits, including for scans and tests?
- Are you able to follow specific study instructions?
What does participation involve?
If you decide to take part, you would first have a screening visit to check if you are suitable for the study. This usually involves health checks, a review of your medical history, and blood tests. If you qualify, you will then visit the clinic for several appointments.
During these visits, you will receive doses of the study medicine, AZD7798. You will also have PET scans and other tests, like blood samples, to see how your body reacts to the medicine. Some visits might require you to stay at the clinic for a longer period, possibly even overnight. The study team will explain the exact schedule of visits, tests, and the total length of your participation, which will include follow-up appointments after you've finished taking the medicine. Your safety will be checked regularly throughout the study.
Potential risks and benefits
Locations (1)
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Common questions
What is a PET scan?
A PET scan is a special type of imaging test that helps doctors see how your organs and tissues are working. It uses a tiny amount of a safe tracing substance that shows up on the scan.
Will this medicine cure my Crohn's disease?
Not directly. This is an early stage study aimed at understanding how a new medicine works, not to treat your condition. However, the information learned could help develop future treatments.
Will I have to stay in hospital?
Some visits might require you to stay at the clinic for a longer period, possibly overnight, but not necessarily a full hospital stay. The study team will provide all the details.
What is 'Phase 1' study?
A Phase 1 study is when a new medicine is given to people for the first time. The main goals are to check if it's safe and to understand how it affects the body.
Can I stop taking part if I change my mind?
Yes, absolutely. You can withdraw from the study at any time, for any reason, without it affecting your current or future medical care.
How to find out more
Always speak to your GP or specialist before deciding to take part in a study.
Discussion
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