Dental Dyschromia and Quality of Life in Early Prolonged Hyperbilirubinemia
This study is investigating why some children who had very high levels of bilirubin in their blood (a condition called hyperbilirubinemia) when they were babies might end up with discoloured teeth. We call this dental dyschromia. Researchers want to understand how often this happens and what might make it more likely, such as how long they had high bilirubin, how high it was, or if they had other health problems. The study also aims to figure out if having discoloured teeth affects a child's everyday life, like how they feel about themselves or interact with others. The results will help make a case for health insurance companies to cover dental treatments for these children.
At a glance
What is this study about?
Imagine your teeth developing a different colour than usual – this is called dental dyschromia. This study is all about understanding why some children who had a condition called hyperbilirubinemia, where there's too much of a yellowish substance called bilirubin in their blood when they were babies, might eventually get discoloured teeth.
The researchers are keen to find out how many children with a history of hyperbilirubinemia experience this problem. They also want to identify things that might make it more likely, like how serious or how long the high bilirubin levels lasted, or if the child had certain other health conditions.
A really important part of this study is to see if having discoloured teeth affects a child's quality of life. This means how happy and comfortable they are with their teeth and smile, and how it impacts their daily life and confidence. The findings from this research will be used to show health insurance companies why covering dental care for these children is so important and should be made easier.
Key takeaways
- This study explores why some children get discoloured teeth after having high bilirubin as babies.
- It aims to understand how discoloured teeth might affect a child's life.
- The findings could help improve health insurance coverage for dental care in these cases.
- Participation involves answering simple questionnaires about your teeth and feelings.
- It's for young people aged 12-18 with specific liver conditions.
Who may be eligible?
This study is looking for young people aged between 12 and 18 years old. To be able to join, they must have one of three specific liver conditions: biliary atresia, progressive familial intrahepatic cholestasis, or Alagille syndrome.
It's also important that the young person, or their parent or guardian, is happy for them to take part. This means they are not against being involved in the research.
However, young people will not be able to join if they have difficulty understanding or answering questions about their quality of life.
Could this study suit you?
Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.
- Are you between 12 and 18 years old?
- Do you have biliary atresia, progressive familial intrahepatic cholestasis, or Alagille syndrome?
- Are you, or your parent/guardian, happy for you to take part in this research?
- Can you understand and answer questions about how you feel about your life?
What does participation involve?
If you decide to take part, the main activity involved will be completing questionnaires. These questionnaires will ask about your quality of life, focusing on how your teeth and smile affect you. There are no medications involved in this study, and no extra doctor's appointments beyond what you would usually have. The total time commitment will be for completing the questionnaires, and the duration of your participation will depend on how long it takes to fill them out.
Potential risks and benefits
Locations (9)
- University Hospital BordeauxVerified postcodeBordeaux, France· Recruiting
- University Hosptial CaenVerified postcodeCaen, France· Recruiting
- University Hospital LilleVerified postcodeLille, France· Recruiting
- Hospices Civils de LyonVerified postcodeLyon, France· Recruiting
- University Hospital MarseilleVerified postcodeMarseille, France· Recruiting
- Assistance Publique-Hôpitaux de Paris, Hôpital Bicêtre, FHU HépatinovVerified postcodeParis, France· Recruiting
- Assistance Publique-Hôpitaux de Paris, Hôpital Bretonneau, ParisVerified postcodeParis, France· Recruiting
- Assistance Publique-Hôpitaux de Paris, Hôpital NeckerVerified postcodeParis, France· Recruiting
- University Hospital RennesVerified postcodeRennes, France· Recruiting
Common questions
What is hyperbilirubinemia?
It's a condition where there's too much of a yellowish substance called bilirubin in the blood, often seen in babies.
What does 'dental dyschromia' mean?
It's the medical term for teeth discolouration, where teeth develop an unusual colour.
Will I have to take any medicine in this study?
No, this study only involves answering questionnaires; no medication is given.
Who is paying for this study?
The information provided only states that the study is being conducted by researchers.
What happens with the information I give?
The information will be used to understand the link between high bilirubin and teeth discolouration, and how it affects quality of life, to advocate for better dental care coverage.
How to find out more
Nolwenn LABORDE, MD
Always speak to your GP or specialist before deciding to take part in a study.
Interested in taking part?
Discussion
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